9 patents
Utility
Precipitation resistant small molecule drug formulations
5 Dec 23
Embodiments of the invention are directed to formulations that provide a solution to the problem of small molecule (e.g., diazepam) precipitation at the injection site when administered as a highly-concentrated formulation.
Steven J. Prestrelski, Michael A. Sandoval, Brian R. Sloat
Filed: 13 May 21
Utility
Methods for producing stable therapeutic glucagon formulations in aprotic polar solvents
28 Feb 23
Certain embodiments are directed to a formulation of a therapeutic agent, as well as a method of making such a formulation, comprising at least one therapeutic agent dissolved in an aprotic polar solvent system comprising at least one ionization stabilizing excipient in a concentration sufficient to impart physical and chemical stability to the therapeutic agent.
Steven Prestrelski, Martin Donovan, Michael Sandoval
Filed: 25 Sep 16
Utility
Stable therapeutic compositions in aprotic polar solvents and methods of manufacturing the same
14 Feb 23
The present invention concerns the use of aprotic polar solvents, water, and an ionization stabilizing agent to prepare device compatible stable therapeutic formulations by dissolving a therapeutic agent (active ingredient) in an aprotic polar solvent system that can then be used with various devices (e.g., pumps, infusion sets) for administration of the formulation.
Martin Donovan, Wendy Hu
Filed: 29 May 20
Utility
Stable formulations for parenteral injection of small molecule drugs
20 Sep 22
Disclosed is a stable liquid formulation for parenteral injection comprising a biocompatible non-aqueous solvent and a small molecule drug, or a salt thereof, solubilized within the non-aqueous solvent, wherein the liquid formulation comprises less than 10% by weight residual water, and wherein the volume of the liquid formulation to be parenterally injected is from 0.1 μl to 3 ml.
Steven J. Prestrelski, Nancy Scott
Filed: 31 Jul 20
Utility
Syringes, kits, and methods for intracutaneous and/or subcutaneous injection of pastes
28 Sep 21
This disclosure includes syringes, kits containing the same, and related methods.
Martin Donovan
Filed: 6 Aug 15
Utility
Precipitation resistant small molecule drug formulations
1 Jun 21
Embodiments of the invention are directed to formulations that provide a solution to the problem of small molecule (e.g., diazepam) precipitation at the injection site when administered as a highly-concentrated formulation.
Steven J. Prestrelski, Michael A. Sandoval, Brian R. Sloat
Filed: 31 May 18
Utility
Stable formulations for parenteral injection of peptide drugs
27 Apr 21
Stable formulations for parenteral injection of peptide drugs and methods of using such stable formulations are provided.
Steven Prestrelski, John Kinzell
Filed: 22 Mar 16
Utility
Stable formulations for parenteral injection of small molecule drugs
7 Sep 20
Disclosed is a stable liquid formulation for parenteral injection comprising a biocompatible non-aqueous solvent and a small molecule drug, or a salt thereof, solubilized within the non-aqueous solvent, wherein the liquid formulation comprises less than 10% by weight residual water, and wherein the volume of the liquid formulation to be parenterally injected is from 0.1 μl to 3 ml.
Steven J. Prestrelski, Nancy Scott
Filed: 28 Jul 15
Utility
Methods for producing stable therapeutic formulations in aprotic polar solvents
25 Nov 19
Certain embodiments are directed to a formulation of a therapeutic agent, as well as a method of making such a formulation, comprising at least one therapeutic agent dissolved in an aprotic polar solvent system comprising at least one ionization stabilizing excipient in a concentration sufficient to impart physical and chemical stability to the therapeutic agent.
Steven Prestrelski, Michael Sandoval, Martin Donovan
Filed: 14 May 17
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