54 patents
Utility
Frataxin Expression Constructs
4 Jan 24
The invention provides polynucleotides, vectors and viruses expressing frataxin and methods of treating Friedreich's Ataxia.
Stephen SCHAUER, Darby THOMAS, Gregory ROBINSON, Mark PYKETT, Richard THORN, Kirsten GRUIS
Filed: 24 Jul 23
Utility
Polypeptide Compositions Comprising Spacers
28 Dec 23
Disclosed herein are methods and compositions including antigen-binding polypeptides comprising a stalk region and a stalk extension region.
Rutul SHAH
Filed: 29 Jun 23
Utility
Biological production of multi-carbon compounds from methane
21 Nov 23
Multi-carbon compounds such as ethanol, n-butanol, sec-butanol, isobutanol, tert-butanol, fatty (or aliphatic long chain) alcohols, fatty acid methyl esters, 2,3-butanediol and the like, are important industrial commodity chemicals with a variety of applications.
William J. Coleman, Genevieve M. Vidanes, Guillaume Cottarel, Sheela Muley, Roy Kamimura, Akbar F. Javan, Jianping Sun, Eli S. Groban
Filed: 24 Nov 20
Utility
Genetically Modified Bacteria Stably Expressing IL-10 and Insulin
2 Nov 23
The current disclosure provides microorganisms, such as lactic acid bacteria (e.g., Lactococcus lactis) containing an exogenous nucleic acid encoding an IL-10 polypeptide and an exogenous nucleic acid encoding a T1D-specific antigen (e.g., a proinsulin) polypeptide, wherein both exogenous nucleic acids are integrated into the bacterial chromosome.
Pieter Rottiers, Lothar Steidler
Filed: 29 Nov 22
Utility
CD33 specific chimeric antigen receptors
17 Oct 23
Provided herein are chimeric antigen receptors (CARs) for cancer therapy, and more particularly, CARs containing a scFv from a CD33 monoclonal antibody.
Rutul Shah, Tim Chan, Peter Emtage, Ramya Yarlagadda
Filed: 7 Jun 17
Utility
Polypeptide compositions comprising spacers
3 Oct 23
Disclosed herein are methods and compositions including antigen-binding polypeptides comprising a stalk region and a stalk extension region.
Rutul R. Shah
Filed: 17 Oct 18
Utility
Hepatitis B Vaccines and Uses of the Same
7 Sep 23
Provided herein are engineered hepatitis B virus (HBV) molecular vaccine constructs.
Douglas E. BROUGH, Cheryl G. BOLINGER, Ramya YARLAGADDA, Vinodhbabu KURELLA, Prabakaran PONRAJ, Simon METENOU, Kuan-Fu DING
Filed: 2 Dec 22
Utility
Modulating expression of polypeptides via new gene switch expression systems
4 Jul 23
Disclosed herein are polynucleotides encoding ligand-inducible gene switch polypeptides, and systems comprising gene switch polypeptides for modulating the expression of a heterologous gene and an interleukin in a host cell.
Rutul R. Shah, Thomas D. Reed, Cheryl G. Bolinger
Filed: 10 Jan 18
Utility
Cryoprotectants for freeze drying of lactic acid bacteria
25 Apr 23
The present invention comprises the discovery and development of an effective cryoprotectant composition, without containing skim milk or any other animal-derived compounds, to achieve long-term stability of freeze-dried lactic acid bacteria (LAB), at different temperatures, whereby the retention of viability of the freeze-dried LAB after 6 months of storage, preferably after 9 months of storage, more preferably after 12 months of storage is more than 50%.
Sam Corveleyn, Patrick Dhaese, Sabine Neirynck, Lothar Steidler
Filed: 5 Feb 20
Utility
Hepatitis B vaccines and uses of the same
21 Mar 23
Provided herein are engineered hepatitis B virus (HBV) molecular vaccine constructs.
Douglas E. Brough, Cheryl G. Bolinger, Ramya Yarlagadda, Vinodhbabu Kurella, Prabakaran Ponraj, Simon Metenou, Kuan-Fu Ding
Filed: 6 Mar 19
Utility
Methods and Microorganisms for the Fermentation of Methane to Multi-carbon Compounds
16 Feb 23
Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as isobutanol are disclosed.
Jeffrey David ORTH, Louis A. CLARK, Lily Yuin CHAO, Na My TRINH, Christopher Cheyney FARWELL, Xinhua ZHAO, Matthias Helmut SCHMALISCH, Grayson Thomas WAWRZYN, Xuezhi LI, Mark Anton HELD, Kevin Lee DIETZEL, James KEALEY
Filed: 11 Jul 22
Utility
Genetically modified bacteria stably expressing IL-10 and insulin
10 Jan 23
The current disclosure provides microorganisms, such as lactic acid bacteria (e.g., Lactococcus lactis) containing an exogenous nucleic acid encoding an IL-10 polypeptide and an exogenous nucleic acid encoding a T1D-specific antigen (e.g., a proinsulin) polypeptide, wherein both exogenous nucleic acids are integrated into the bacterial chromosome.
Pieter Rottiers, Lothar Steidler
Filed: 9 Nov 20
Utility
Fusion constructs and methods of using thereof
27 Dec 22
Provided herein is a composition comprising a fusion protein or a fragment or a variant thereof comprising an anti-PD1 antibody or a fragment/variant thereof and a TGF-β trap.
Helen Sabzevari, Simon Metenou, ChangHung Chen, Rutul R. Shah
Filed: 9 Jul 19
Utility
Buffer Solutions for Electroporation
8 Sep 22
An electroporation buffer comprising: a solvent; a sugar; a chloride salt; and a buffering agent.
Bryan BUTMAN, Robert Daniel SLONE, Steven ROBERTS, Chad B. GREEN, Vincent SO
Filed: 28 Feb 22
Utility
Methods and microorganisms for the fermentation of methane to multi-carbon compounds
23 Aug 22
Genetically modified microorganisms that have the ability to convert carbon substrates into multicarbon products.
Jeffrey David Orth, Louis A. Clark, Lily Yuin Chao, Na My Trinh, Christopher Cheyney Farwell, Xinhua Zhao, Matthias Helmut Schmalisch, Grayson Thomas Wawrzyn, Xuezhi Li, Mark Anton Held, Kevin Lee Dietzel, James Kealey
Filed: 27 Apr 18
Utility
Chimeric Receptor Therapy
14 Jul 22
A non-naturally occurring polynucleotide encoding a miRNA that inhibits the expression of an immune checkpoint protein.
Helen SABZEVARI, Cheryl G. BOLINGER, Rutul R. SHAH, ChangHung CHEN, Vinodhbabu KURELLA, Amy WESA
Filed: 10 Jan 22
Utility
MUC16 specific chimeric antigen receptors and uses thereof
3 May 22
Provided herein are chimeric antigen receptors (CARs) for cancer therapy, and more particularly, CARs containing a scFv from an anti-MUC16 monoclonal antibody.
Helen Sabzevari, Rutul R. Shah
Filed: 4 Jun 19
Utility
Molecular Switches
14 Apr 22
Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as 2,3-BDO; 1,4-BDO; isobutyraldehyde; isobutanol; 1-butanol; n-butanol; ethanol; fatty alcohols; and fatty acid methyl ester are disclosed.
Mark Anton HELD, Xinhua ZHAO, Lily Yuin CHAO, Na TRINH, James KEALEY, Kevin Lee DIETZEL
Filed: 8 Nov 21
Utility
Compositions and Methods for Expression of Multiple Biologically Active Polypeptides from a Single Vector for Treatment of Cardiac Conditions and Other Pathologies
10 Mar 22
The present invention provides compositions and methods useful for treating disorders amenable to therapy via introduction of multigenic expression vectors.
Dimki S. Patel, Amit N. Patel
Filed: 22 Sep 21
Utility
Expression of Novel Cell Tags
3 Mar 22
Disclosed herein are polynucleotides encoding cell tags for use in immunotherapeutic applications, and systems comprising polynucleotide cell tags for regulating the activity of a cell.
Rutul SHAH, Peter EMTAGE, Ramya YARLAGADDA
Filed: 11 Jun 21