57 patents
Utility
Antibodies with Engineered CH2 Domains, Compositions Thereof and Methods of Using the Same
11 Jan 24
The present disclosure relates to antibodies and antibody conjugates having one or more site-specific mutations in the CH2 domain of the heavy chain.
Daniel CALARESE, Gang YIN
Filed: 24 Jul 23
Utility
Hemiasterlin derivatives for conjugation and therapy
9 Jan 24
Toni Kline, Qun Yin, Krishna Bajjuri
Filed: 2 Nov 20
Utility
Immunomodulator antibody drug conjugates and uses thereof
5 Sep 23
Provided herein are compounds, trifunctional antibody products thereof, and methods and pharmaceutical compositions for use in treatment of inflammatory and/or proliferative diseases.
Alice Yam, Andreas Maderna, Cristina Abrahams, Willy Solis, Xiaofan Li, Ryan Stafford, Gang Yin, Venita De Almeida, Krishna Bajjuri, Adam A. Galan
Filed: 10 Jun 20
Utility
Anti-CD74 antibody conjugates, compositions comprising anti-CD74 antibody conjugates and methods of using anti-CD74 antibody conjugates
25 Jul 23
Provided herein are antibody conjugates with binding specificity for CD74 and compositions comprising the antibody conjugates, including pharmaceutical compositions, methods of producing the conjugates, and methods of using the conjugates and compositions for therapy.
Ryan Stafford, Alice Yam, Avinash Gill, Kalyani Penta, Xiaofan Li, Aaron Sato
Filed: 27 Jan 17
Utility
Modified Amino Acids
4 May 23
Provided herein are modified amino acids comprising an azido group, polypeptides, antibodies and conjugates comprising the modified amino acids, and methods of producing the polypeptides, antibodies and conjugates comprising the modified amino acids.
Ryan Stafford, Christopher D. THANOS, Wenijin YANG
Filed: 17 Dec 22
Utility
Antibodies Comprising Multiple Site-specific Non-natural Amino Acid Residues, Methods of Their Preparation and Methods of Their Use
13 Apr 23
Provided herein are antibodies comprising multiple non-natural amino acid residues at site-specific positions, compositions comprising the antibodies, methods of their production and methods of their use.
Christopher D. THANOS, Ramesh BALIGA, Kalyani PENTA, Avinash GILL, Gang YIN, Erik ZIMMERMAN
Filed: 22 Apr 22
Utility
Antibodies Comprising Site-specific Glutamine Tags, Methods of Their Preparation and Methods of Their Use
30 Mar 23
Provided herein are antibodies comprising acceptor glutamine sequences at site-specific positions, compositions comprising the antibodies, conjugates of the antibodies, methods of their production, and methods of their use.
Junhao YANG, Jeffrey HANSON, Ryan STAFFORD, Gang YIN
Filed: 3 Mar 21
Utility
Modified amino acids
10 Jan 23
Provided herein are modified amino acids comprising an azido group, polypeptides, antibodies and conjugates comprising the modified amino acids, and methods of producing the polypeptides, antibodies and conjugates comprising the modified amino acids.
Ryan Stafford, Christopher D. Thanos, Wenjin Yang
Filed: 4 Aug 20
Utility
E. Coli Strains Having an Oxidative Cytoplasm
5 Jan 23
This disclosure provides an E. coli strain, which lacks thioredoxin reductase activity encoded by trxB and thioredoxin 1 activity encoded by trxA, and glutathione reductase activity encoded by gor.
Daniel Groff
Filed: 29 Jun 22
Utility
Anti-bcma Antibody Conjugates
17 Nov 22
The present disclosure relates to antibody conjugates with binding specificity for BCMA (BCMA) and its isoforms and homologs, and compositions comprising the antibody conjugates, including pharmaceutical compositions.
John LEE, Ryan STAFFORD, Alice YAM, Xiaofan LI, Abigail YU, Amandeep GAKHAL, Stephanie ARMSTRONG
Filed: 1 May 20
Utility
1-(4-(AMINOMETHYL)BENZYL)-2-BUTYL-2H-PYRAZOLO[3,4-C]QUINOLIN-4-AMINE Derivatives and Related Compounds As Toll-like Receptor (TLR) 7/8 Agonists, As Well As Antibody Drug Conjugates Thereof for Use In Cancer Therapy and Diagnosis
18 Aug 22
Labros MEIMETIS
Filed: 17 Jun 20
Utility
Unknown
9 Aug 22
This disclosure provides an E. coli strain, which lacks thioredoxin reductase activity encoded by trxB and thioredoxin 1 activity encoded by trxA, and glutathione reductase activity encoded by gor.
Daniel Groff
Filed: 7 Nov 19
Utility
Formulations for drying bacterial cell extracts
9 Aug 22
This invention provides for an improved method of stabilizing freeze dried bacterial extracts with a carbohydrate lyoprotectant such that the extracts can be for use in cell free protein synthesis.
Martin Chandler, Kirk Hayenga, Henry Heinsohn
Filed: 6 Apr 20
Utility
5H-PYRROLO[3,2-d]PYRIMIDINE-2,4-DIAMINO COMPOUNDS AND ANTIBODY CONJUGATES THEREOF
4 Aug 22
The present disclosure relates to 5H-Pyrrolo[3,2-d]pyrimidine-2,4-diamino compounds, and/or antibody conjugates thereof; and pharmaceutical compositions thereof, methods of producing the conjugates, and methods of using the conjugates and compositions for therapy.
Andreas MADERNA, Adam A. GALAN, Krishna BAJJURI
Filed: 10 Jun 20
Utility
Antibodies with Engineered CH2 Domains, Compositions Thereof and Methods of Using the Same
30 Jun 22
The present disclosure relates to antibodies and antibody conjugates having one or more site-specific mutations in the CH2 domain of the heavy chain.
Daniel CALARESE, Gang YIN
Filed: 28 Jul 21
Utility
Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use
31 May 22
Provided herein are antibodies comprising multiple non-natural amino acid residues at site-specific positions, compositions comprising the antibodies, methods of their production and methods of their use.
Christopher D. Thanos, Ramesh Baliga, Kalyani Penta, Avinash Gill, Gang Yin, Erik Zimmerman
Filed: 15 Aug 17
Utility
Method for Large Scale Production of Antibodies Using a Cell-free Protein Synthesis System
24 Mar 22
Described herein are methods for large scale production of antibodies using a cell-free protein synthesis system.
Gang Yin
Filed: 13 Sep 21
Utility
Proteolytic inactivation of select proteins in bacterial extracts for improved expression
1 Mar 22
The present disclosure provides modified proteins that are capable of being cleaved by the protease OmpT1.
Christopher D. Thanos, Christopher J. Murray, Junhao Yang, Heather Stephenson
Filed: 6 Sep 19
Utility
Combination Therapies with Anti-folate Receptor Antibody Conjugates
17 Feb 22
The present disclosure relates to combination therapies with antibody conjugates with binding specificity for folate receptor alpha (FOLR1) and its isoforms and homologs, and compositions comprising combinations with the antibody conjugates, including pharmaceutical compositions.
Venita De ALMEIDA
Filed: 16 Sep 19
Utility
ANTI-TIM-3 Antibodies, Compositions Comprising ANTI-TIM-3 Antibodies and Methods of Making and Using ANTI-TIM-3 Antibodies
30 Dec 21
Provided herein are antibodies that selectively bind to Tim-3 and its isoforms and homologs, and compositions comprising the antibodies.
Ryan STAFFORD, Alice YAM, John LEE, Junhao YANG, Aaron SATO
Filed: 6 May 21