57 patents
Page 3 of 3
Utility
Use of lambda-gam protein in ribosomal display technology
3 Aug 20
Methods and systems for increasing the stability of a nucleic acid template that encodes a protein of interest in a cell free translation system or a ribosomal display reaction system are described.
Ryan Stafford, Christopher D. Thanos
Filed: 9 Jan 18
Utility
Modified amino acids
3 Aug 20
Provided herein are modified amino acids comprising an azido group, polypeptides, antibodies and conjugates comprising the modified amino acids, and methods of producing the polypeptides, antibodies and conjugates comprising the modified amino acids.
Ryan Stafford, Christopher D. Thanos, Wenjin Yang
Filed: 28 Oct 18
Utility
Methods of Using ANTI-CD74 Antibodies and Antibody Conjugates In Treatment of T-cell Lymphoma
1 Jul 20
Provided herein are antibody conjugates with binding specificity for CD74 and compositions comprising the antibody conjugates, including pharmaceutical compositions, methods of producing the conjugates, and methods of using the conjugates and compositions for therapy involving treatment, amelioration, and/or diagnosis of a T-cell lymphoma.
Arturo MOLINA
Filed: 24 Jul 18
Utility
PD-1/TIM-3 Bi-specific Antibodies, Compositions Thereof, and Methods of Making and Using the Same
17 Jun 20
Provided herein are antibodies that selectively bind to Tim-3 and its isoforms and homologs, and compositions comprising the antibodies.
Ryan STAFFORD, Alice YAM, Stephanie ARMSTRONG, John LEE, Alexander STEINER, Junhao YANG, Christine CHENG
Filed: 21 Feb 18
Utility
Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use
1 Jun 20
Provided herein are antibodies comprising non-natural amino acid residues at site-specific positions, compositions comprising the antibodies, methods of their production and methods of their use.
Christopher D. Thanos, Leslie McEvoy, Gang Yin, Kalyani Penta, Ramesh Baliga, Sunil Bajad, Sonia Pollitt, Chris Murray, Alex Steiner, Avinash Gill
Filed: 22 Jun 17
Utility
Anti-folate Receptor Antibody Conjugates, Compositions Comprising Anti-folate Receptor Antibody Conjugates, and Methods of Making and Using Anti-folate Receptor Antibody Conjugates
13 May 20
The present disclosure relates to antibody conjugates with binding specificity for folate receptor alpha (FOLR1) and its isoforms and homologs, and compositions comprising the antibody conjugates, including pharmaceutical compositions.
Ryan STAFFORD, Alice YAM, Xiaofan LI, Gang YIN, Toni KLINE, Cristina ABRAHAMS, Venita DE ALMEIDA
Filed: 15 Sep 19
Utility
Formulations for drying bacterial cell extracts
11 May 20
This invention provides for an improved method of stabilizing freeze dried bacterial extracts with a carbohydrate lyoprotectant such that the extracts can be for use in cell free protein synthesis.
Martin Chandler, Kirk Hayenga, Henry Heinsohn
Filed: 7 Jan 16
Utility
Anti-folate receptor antibody conjugates, compositions comprising anti-folate receptor antibody conjugates, and methods of making and using anti-folate receptor antibody conjugates
23 Mar 20
The present disclosure relates to antibody conjugates with binding specificity for folate receptor alpha (FOLR1) and its isoforms and homologs, and compositions comprising the antibody conjugates, including pharmaceutical compositions.
Ryan Stafford, Alice Yam, Xiaofan Li, Gang Yin, Toni Kline, Cristina Abrahams, Venita De Almeida
Filed: 16 Sep 18
Utility
PD-1/LAG3 Bi-specific Antibodies, Compositions Thereof, and Methods of Making and Using the Same
11 Mar 20
Provided herein are antibodies that selectively bind to LAG3 and its isoforms and homologs, and compositions comprising the antibodies.
Ryan STAFFORD, Alice YAM, Stephanie ARMSTRONG, John LEE, Alexander STEINER, Junhao YANG, Christine CHENG
Filed: 22 May 18
Utility
Proteolytic Inactivation of Select Proteins In Bacterial Extracts for Improved Expression
26 Feb 20
The present disclosure provides modified proteins that are capable of being cleaved by the protease OmpT1.
Christopher D. Thanos, Christopher J. Murray, Junhao Yang, Heather Stephenson
Filed: 5 Sep 19
Utility
Modified Amino Acids Comprising Tetrazine Functional Groups, Methods of Preparation, and Methods of Their Use
8 Jan 20
Wenjin YANG, Qun YIN
Filed: 17 Sep 19
Utility
Modified Fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use
9 Dec 19
Provided herein are modified Fc proteins comprising non-natural amino acid residues at site-specific positions, conjugates of the modified Fc proteins for therapy or diagnosis, compositions comprising the modified Fc proteins and conjugates thereof, methods of their production and methods of their use.
Christopher D. Thanos, Leslie McEvoy, Gang Yin, Kalyani Penta, Ramesh Baliga, Sunil Bajad, Sonia Pollitt, Chris Murray, Alex Steiner, Avinash Gill
Filed: 22 Jun 17
Utility
Codon optimization for titer and fidelity improvement
25 Nov 19
The invention provides methods for producing a protein in a cell free protein synthesis system such that the protein does not contain an asparagine (Asn or N) residue at serine (Ser or S) positions.
Gang Yin
Filed: 17 Dec 15
Utility
High Growth Capacity Auxotrophic Escherichia Coli and Methods of Use
6 Nov 19
This invention provides high growth capacity strains of auxotrophic Escherichia coli and methods for generating thereof.
Dan Groff, Patrick Rivers, Stuart Bussell, Alexander Steiner
Filed: 25 Apr 19
Utility
ANTI-LAG3 Antibodies, Compositions Comprising ANTI-LAG3 Antibodies and Methods of Making and Using ANTI-LAG3 Antibodies
30 Oct 19
Provided herein are antibodies that selectively bind to LAG3 and its isoforms and homologs, and compositions comprising the antibodies.
Ryan STAFFORD, Alice YAM, John LEE, Aaron SATO
Filed: 17 Nov 16
Utility
Proteolytic inactivation of select proteins in bacterial extracts for improved expression
21 Oct 19
The present disclosure provides modified proteins that are capable of being cleaved by the protease OmpT1.
Christopher D. Thanos, Christopher J. Murray, Junhao Yang, Heather Stephenson
Filed: 9 Apr 17
Utility
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
14 Oct 19
Wenjin Yang, Qun Yin
Filed: 5 Dec 17