24 patents
Utility
Hemiasterlin derivatives for conjugation and therapy
9 Jan 24
Toni Kline, Qun Yin, Krishna Bajjuri
Filed: 2 Nov 20
Utility
Immunomodulator antibody drug conjugates and uses thereof
5 Sep 23
Provided herein are compounds, trifunctional antibody products thereof, and methods and pharmaceutical compositions for use in treatment of inflammatory and/or proliferative diseases.
Alice Yam, Andreas Maderna, Cristina Abrahams, Willy Solis, Xiaofan Li, Ryan Stafford, Gang Yin, Venita De Almeida, Krishna Bajjuri, Adam A. Galan
Filed: 10 Jun 20
Utility
Anti-CD74 antibody conjugates, compositions comprising anti-CD74 antibody conjugates and methods of using anti-CD74 antibody conjugates
25 Jul 23
Provided herein are antibody conjugates with binding specificity for CD74 and compositions comprising the antibody conjugates, including pharmaceutical compositions, methods of producing the conjugates, and methods of using the conjugates and compositions for therapy.
Ryan Stafford, Alice Yam, Avinash Gill, Kalyani Penta, Xiaofan Li, Aaron Sato
Filed: 27 Jan 17
Utility
Modified amino acids
10 Jan 23
Provided herein are modified amino acids comprising an azido group, polypeptides, antibodies and conjugates comprising the modified amino acids, and methods of producing the polypeptides, antibodies and conjugates comprising the modified amino acids.
Ryan Stafford, Christopher D. Thanos, Wenjin Yang
Filed: 4 Aug 20
Utility
Unknown
9 Aug 22
This disclosure provides an E. coli strain, which lacks thioredoxin reductase activity encoded by trxB and thioredoxin 1 activity encoded by trxA, and glutathione reductase activity encoded by gor.
Daniel Groff
Filed: 7 Nov 19
Utility
Formulations for drying bacterial cell extracts
9 Aug 22
This invention provides for an improved method of stabilizing freeze dried bacterial extracts with a carbohydrate lyoprotectant such that the extracts can be for use in cell free protein synthesis.
Martin Chandler, Kirk Hayenga, Henry Heinsohn
Filed: 6 Apr 20
Utility
Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use
31 May 22
Provided herein are antibodies comprising multiple non-natural amino acid residues at site-specific positions, compositions comprising the antibodies, methods of their production and methods of their use.
Christopher D. Thanos, Ramesh Baliga, Kalyani Penta, Avinash Gill, Gang Yin, Erik Zimmerman
Filed: 15 Aug 17
Utility
Proteolytic inactivation of select proteins in bacterial extracts for improved expression
1 Mar 22
The present disclosure provides modified proteins that are capable of being cleaved by the protease OmpT1.
Christopher D. Thanos, Christopher J. Murray, Junhao Yang, Heather Stephenson
Filed: 6 Sep 19
Utility
Antibodies with engineered CH2 domains, compositions thereof and methods of using the same
24 Aug 21
The present disclosure relates to antibodies and antibody conjugates having one or more site-specific mutations in the CH2 domain of the heavy chain.
Daniel Calarese, Gang Yin
Filed: 14 Jun 17
Utility
Anti-EpCAM antibodies, compositions comprising anti-EpCAM antibodies and methods of making and using anti-EpCAM antibodies
24 Aug 21
Provided herein are antibodies that selectively bind to EpCAM and its isoforms and homologs, and compositions comprising the antibodies.
Ryan Stafford, Alice Yam, John Lee, Stephanie Armstrong, Aaron Sato
Filed: 28 Jul 16
Utility
Anti-Tim-3 antibodies, compositions comprising anti-Tim-3 antibodies and methods of making and using anti-Tim-3 antibodies
25 May 21
Provided herein are antibodies that selectively bind to Tim-3 and its isoforms and homologs, and compositions comprising the antibodies.
Ryan Stafford, Alice Yam, John Lee, Junhao Yang, Aaron Sato
Filed: 17 Aug 16
Utility
Anti-CD74 antibodies, compositions comprising anti-CD74 antibodies and methods of using anti-CD74 antibodies
13 Apr 21
Provided herein are antibodies that selectively bind to CD74 and its isoforms and homologs, and compositions comprising the antibodies.
Kalyani Penta, Ryan Stafford, Avinash Gill, Xiaofan Li, Alice Yam, Christopher Thanos, Aaron Sato
Filed: 20 Jul 15
Utility
Hemiasterlin derivatives for conjugation and therapy
23 Nov 20
Toni Kline, Qun Yin, Krishna Bajjuri
Filed: 28 Jan 16
Utility
Anti-PD-1 antibodies, compositions comprising anti-PD-1 antibodies and methods of using anti-PD-1 antibodies
2 Nov 20
Provided herein are antibodies that selectively bind to PD-1 and its isoforms and homologs, and compositions comprising the antibodies.
Alice Yam, Ryan Stafford, Aaron Sato, John Lee, Avinash Gill, Junhao Yang, Heather Stephenson
Filed: 9 Nov 15
Utility
Expression of biologically active proteins in a bacterial cell-free synthesis system using bacterial cells transformed to exhibit elevated levels of chaperone expression
14 Sep 20
The present disclosure describes methods and systems for improving the expression of a properly folded, biologically active protein of interest in a cell free synthesis system.
Alice Yam, Dan Groff, Patrick Rivers, Christopher D. Thanos
Filed: 2 Dec 18
Utility
Use of lambda-gam protein in ribosomal display technology
3 Aug 20
Methods and systems for increasing the stability of a nucleic acid template that encodes a protein of interest in a cell free translation system or a ribosomal display reaction system are described.
Ryan Stafford, Christopher D. Thanos
Filed: 9 Jan 18
Utility
Modified amino acids
3 Aug 20
Provided herein are modified amino acids comprising an azido group, polypeptides, antibodies and conjugates comprising the modified amino acids, and methods of producing the polypeptides, antibodies and conjugates comprising the modified amino acids.
Ryan Stafford, Christopher D. Thanos, Wenjin Yang
Filed: 28 Oct 18
Utility
Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use
1 Jun 20
Provided herein are antibodies comprising non-natural amino acid residues at site-specific positions, compositions comprising the antibodies, methods of their production and methods of their use.
Christopher D. Thanos, Leslie McEvoy, Gang Yin, Kalyani Penta, Ramesh Baliga, Sunil Bajad, Sonia Pollitt, Chris Murray, Alex Steiner, Avinash Gill
Filed: 22 Jun 17
Utility
Formulations for drying bacterial cell extracts
11 May 20
This invention provides for an improved method of stabilizing freeze dried bacterial extracts with a carbohydrate lyoprotectant such that the extracts can be for use in cell free protein synthesis.
Martin Chandler, Kirk Hayenga, Henry Heinsohn
Filed: 7 Jan 16
Utility
Anti-folate receptor antibody conjugates, compositions comprising anti-folate receptor antibody conjugates, and methods of making and using anti-folate receptor antibody conjugates
23 Mar 20
The present disclosure relates to antibody conjugates with binding specificity for folate receptor alpha (FOLR1) and its isoforms and homologs, and compositions comprising the antibody conjugates, including pharmaceutical compositions.
Ryan Stafford, Alice Yam, Xiaofan Li, Gang Yin, Toni Kline, Cristina Abrahams, Venita De Almeida
Filed: 16 Sep 18