24 patents
Page 2 of 2
Utility
Modified Fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use
9 Dec 19
Provided herein are modified Fc proteins comprising non-natural amino acid residues at site-specific positions, conjugates of the modified Fc proteins for therapy or diagnosis, compositions comprising the modified Fc proteins and conjugates thereof, methods of their production and methods of their use.
Christopher D. Thanos, Leslie McEvoy, Gang Yin, Kalyani Penta, Ramesh Baliga, Sunil Bajad, Sonia Pollitt, Chris Murray, Alex Steiner, Avinash Gill
Filed: 22 Jun 17
Utility
Codon optimization for titer and fidelity improvement
25 Nov 19
The invention provides methods for producing a protein in a cell free protein synthesis system such that the protein does not contain an asparagine (Asn or N) residue at serine (Ser or S) positions.
Gang Yin
Filed: 17 Dec 15
Utility
Proteolytic inactivation of select proteins in bacterial extracts for improved expression
21 Oct 19
The present disclosure provides modified proteins that are capable of being cleaved by the protease OmpT1.
Christopher D. Thanos, Christopher J. Murray, Junhao Yang, Heather Stephenson
Filed: 9 Apr 17
Utility
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
14 Oct 19
Wenjin Yang, Qun Yin
Filed: 5 Dec 17