58 patents
Page 3 of 3
Utility
Stable heterodimeric antibody design with mutations in the Fc domain
28 Dec 20
The provided scaffolds have heavy chains that are asymmetric in the various domains (e.g.
Thomas Spreter Von Kreudenstein, Eric Escobar-Cabrera, Surjit Bhimarao Dixit, Paula Irene Lario, David Kai Yuen Poon
Filed: 17 Jan 17
Utility
System for molecular packing calculations
9 Nov 20
The invention provides a computer implemented method of quantifying the quality of packing for a residue comprising one or more residue atoms in a first protein in a first conformation, the method comprising: (a) calculating one or more close contact potentials based on a distance between the one or more residue atoms and one or more environment atoms, (b) calculating a contact area of the one or more residue atoms that is exposed to the one or more environment atoms and (c) calculating a close contact surface density (CCSD) by dividing the sum of the one or more close contact potentials by the contact area.
Anders Ohrn
Filed: 21 Sep 11
Utility
Stabilized Chimeric Fabs
30 Sep 20
Provided herein are stabilized chimeric Fabs derived from a parent chimeric Fab having a lambda light chain.
Dunja UROSEV, Yang-Chieh CHOU
Filed: 28 Jun 18
Utility
Methods of Using Bispecific Antigen-binding Constructs Targeting HER2
23 Sep 20
Described herein methods of using antigen-binding constructs to treat HER2+ tumors in a subject such as breast, lung, or head and neck tumors.
Gordon Yiu Kon Ng
Filed: 24 Apr 17
Utility
Multivalent heteromultimer scaffold design and constructs
13 Jul 20
Provided herein are multifunctional heteromer proteins.
Surjit Bhimarao Dixit, Igor Edmondo Paolo D'Angelo, David Kai Yuen Poon
Filed: 4 Nov 18
Utility
RepublicationCytotoxic and Anti-mitotic Compounds, and Methods of Using the Same
1 Jul 20
Compounds having cytotoxic and/or anti-mitotic activity are disclosed.
Geoffrey WINTERS, James RICH, Graham GARNETT, Alexander MANDEL, Tom HSIEH, Elyse BOURQUE, Stuart BARNSCHER
Filed: 25 Jul 19
Utility
VAR2CSA-drug conjugates
8 Jun 20
VAR2CSA-drug conjugates having biological activity are disclosed.
James R. Rich, John Babcook, Ali El-Salanti, Mads Daugaard, Madeleine Dahlback, Bradley J. Hedberg, Geoffrey C. Winters, Alexander L. Mandel, Elyse Marie Josée Bourque, Tom Han Hsiao Hsieh
Filed: 28 Dec 14
Utility
ANTI-HER2 Biparatopic Antibody-drug Conjugates and Methods of Use
8 Apr 20
Anti-HER2 biparatopic antibody-drug conjugates (ADCs) in which the drug is an auristatin analogue and is conjugated to the antibody at a low average drug-to-antibody ratio (DAR), and methods of using the ADCs in the treatment of a HER2-expressing cancer.
Kevin Hamblett, Rupert H. Davies, James R. Rich, Gerald J. Rowse, Vincent K.C. Fung, Stuart D. Barnscher
Filed: 6 Oct 19
Utility
STABLE HETERODIMERIC ANTIBODY DESIGN WITH MUTATIONS IN THE Fc DOMAIN
18 Mar 20
The provided scaffolds have heavy chains that are asymmetric in the various domains (e.g.
Thomas Spreter Von Kreudenstein, Surjit Bhimarao Dixit, Eric Escobar-Cabrera, Paula Irene Lario, David Kai Yuen Poon
Filed: 11 Sep 19
Utility
Tumor Antigen Presentation Inducer Constructs and Uses Thereof
12 Feb 20
Provided herein are tumor-associated antigen (TAA) presentation inducer constructs comprising at least one innate stimulatory receptor (ISR)-binding construct that binds to an ISR expressed on an antigen-presenting cell (APC), and at least one TAA-binding construct that binds directly to a first TAA that is physically associated with tumor cell-derived material (TCDM) comprising one or more other TAAs.
David M. Mills, Eric Escobar-Cabrera
Filed: 28 Mar 18
Utility
Compositions and methods for the treatment of platinum-drug resistant cancer
30 Dec 19
VAR2CSA-drug conjugates for targeting and inhibiting the growth of cancer cells that have developed resistance to a platinum drug and the use of the conjugates in the treatment of platinum drug-resistant cancers.
John Babcook, James R. Rich, Mads Daugaard, Ali El-Salanti
Filed: 3 Oct 17
Utility
Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells
16 Dec 19
The present invention provides a process and methods for producing asymmetric antibodies in a mammalian expression system.
Surjit Bhimarao Dixit, Gordon Yiu Kon NG, Thomas Spreter Von Kreudenstein
Filed: 16 Nov 16
Utility
Multivalent Heteromultimer Scaffold Design and Constructs
11 Dec 19
Provided herein are multifunctional heteromultimer proteins.
Surjit Bhimarao Dixit, Igor Edmondo Paolo D'Angelo, Mario Sanches, Gordon Yiu Kon Ng
Filed: 20 May 19
Utility
Systems and methods for sampling and analysis of polymer conformational dynamics
18 Nov 19
Systems and methods for searching conformation space of a polymer to determine a three-dimensional conformation of the polymer that satisfies a performance metric is provided.
Surjit Bhimarao Dixit
Filed: 15 Aug 13
Utility
Cytotoxic and Anti-mitotic Compounds, and Methods of Using the Same
13 Nov 19
Compounds having cytotoxic and/or anti-mitotic activity are disclosed.
Geoffrey C. WINTERS, James R. RICH, Graham Albert Edwin GARNETT, Alexander Laurence MANDEL, Tom Han Hsiao HSIEH, Elyse Marie Josée BOURQUE, Stuart Daniel BARNSCHER
Filed: 25 Jul 19
Utility
Antigen-Binding Polypeptide Constructs Comprising Kappa and Lambda Light Chains and Uses Thereof
6 Nov 19
Provided herein are multispecific antigen-binding polypeptide constructs comprising at least two different heterodimers, each comprising a heavy chain and a light chain.
Dunja UROSEV, Stacy A.L. TOM-YEW, Leonard G. PRESTA, Mario SANCHES
Filed: 6 Oct 16
Utility
Stable heterodimeric antibody design with mutations in the Fc domain
28 Oct 19
The provided scaffolds have heavy chains that are asymmetric in the various domains (e.g.
Thomas Spreter Von Kreudenstein, Surjit Bhimarao Dixit, Eric Escobar-Cabrera, Paula Irene Lario, David Kai Yuen Poon
Filed: 19 Jan 17
Utility
Cytotoxic and anti-mitotic compounds, and methods of using the same
21 Oct 19
Compounds having cytotoxic and/or anti-mitotic activity are disclosed.
Geoffrey C. Winters, James R. Rich, Graham Albert Edwin Garnett, Alexander Laurence Mandel, Tom Han Hsiao Hsieh, Elyse Marie Josee Bourque, Stuart Daniel Barnscher
Filed: 16 Sep 15