21 patents
Utility
Peptidomimetic Macrocycles and Formulations Thereof
27 Apr 23
Aqueous pharmaceutical formulations, for parenteral administration, comprising peptidomimetic macrocycle or a pharmaceutically acceptable salt thereof wherein the peptidomimetic macrocycle binds to MDM2 and/or MDMX proteins are disclosed.
David Allen ANNIS, Krzysztof DARLAK, Chris RHODES, Sonoko KANAI, Joerg HOERNSCHEMEYER, Michaela GRASS
Filed: 16 Jun 22
Utility
Peptidomimetic Macrocycles
20 Apr 23
Provided herein are peptidomimetic macrocycles containing amino acid sequences with at least two modified amino acids that form an intramolecular cross-link that can help to stabilize a secondary structure of the amino acid sequence.
Vincent GUERLAVAIS, Carl ELKIN, Huw M. NASH, Tomi K. SAWYER, Bradford J. GRAVES, Eric FEYFANT
Filed: 22 Jun 22
Utility
Peptidomimetic Macrocycles and Uses Thereof
6 Apr 23
Methods for treating a solid tumor, determined to lack a p53 deactivation mutation, in a subject are provided.
Hubert CHEN, David Allen ANNIS, Yong CHANG, Manuel AIVADO, Karen OLSON, Chris VIAU
Filed: 21 Jun 22
Utility
CorrectedCombination Therapy of Peptidomimetic Macrocycles
2 Feb 23
The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition.
Vincent GUERLAVAIS, David Allen ANNIS
Filed: 28 May 21
Utility
Methods for Preparing Purified Polypeptide Compositions
20 Jan 22
The present invention relates to purified peptidomimetic macrocycles.
Huw M. Nash, Matthew Iadanza, Christopher Leitheiser, Noriyuki Kawahata
Filed: 23 Jul 21
Utility
Peptidomimetic Macrocycles
6 Jan 22
Provided herein are peptidomimetic macrocycles containing amino acid sequences with at least two modified amino acids that form an intramolecular cross-link that can help to stabilize a secondary structure of the amino acid sequence.
Vincent GUERLAVAIS, Carl ELKIN, Huw M. NASH, Tomi K. SAWYER, Bradford J. GRAVES, Eric FEYFANT
Filed: 22 Jan 21
Utility
Combination Therapy of Peptidomimetic Macrocycles
25 Nov 21
The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition.
Vincent GUERLAVAIS, David Allen ANNIS
Filed: 28 May 21
Utility
Peptidomimetic Macrocycles and Formulations Thereof
30 Sep 21
Aqueous pharmaceutical formulations, for parenteral administration, comprising peptidomimetic macrocycle or a pharmaceutically acceptable salt thereof wherein the peptidomimetic macrocycle binds to MDM2 and/or MDMX proteins are disclosed.
David Allen Annis, Krzysztof Darlak, Chris Rhodes, Sonoko Kanai, Joerg Hoernschemeyer, Michaela Grass
Filed: 6 Nov 20
Utility
Peptidomimetic macrocycles and uses thereof
17 Aug 21
The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition.
Manuel Aivado, Vincent Guerlavais, Karen Olson, David Allen Annis
Filed: 23 Jul 19
Utility
Peptidomimetic macrocycles
18 May 21
The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
Vincent Guerlavais, Noriyuki Kawahata
Filed: 6 Sep 19
Utility
Peptidomimetic macrocycles
6 Apr 21
Provided herein are peptidomimetic macrocycles containing amino acid sequences with at least two modified amino acids that form an intramolecular cross-link that can help to stabilize a secondary structure of the amino acid sequence.
Vincent Guerlavais, Carl Elkin, Huw M. Nash, Tomi K. Sawyer, Bradford J. Graves, Eric Feyfant
Filed: 18 Dec 18
Utility
Peptidomimetic macrocycles and formulations thereof
2 Feb 21
Aqueous pharmaceutical formulations, for parenteral administration, comprising peptidomimetic macrocycle or a pharmaceutically acceptable salt thereof wherein the peptidomimetic macrocycle binds to MDM2 and/or MDMX proteins are disclosed.
David Allen Annis, Krzysztof Darlak, Chris Rhodes, Sonoko Kanai, Joerg Hoernschemeyer, Michaela Grass
Filed: 24 Sep 15
Utility
Peptidomimetic Macrocycles and Uses Thereof
25 Nov 20
Provided herein are peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
Manuel AIVADO, Vincent GUERLAVAIS, Karen OLSON
Filed: 21 May 20
Utility
Peptidomimetic Macrocycles and Uses Thereof
16 Sep 20
The present disclosure describes methods of using peptidomimetic macrocycles in combination with an additional therapy to treat a condition, for example, cancer.
Vojislav VUKOVIC, Luis CARVAJAL, David Allen ANNIS
Filed: 12 Mar 20
Utility
Peptidomimetic macrocycles
6 Jul 20
The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
Vincent Guerlavais, Noriyuki Kawahata
Filed: 9 Sep 18
Utility
Disubstituted amino acids and methods of preparation and use thereof
1 Jun 20
Provided are crystalline α, α-disubstituted amino acids and their crystalline salts containing a terminal alkene on one of their side chains, as well as optionally crystalline halogenated and deuterated analogs of the α, α-disubstituted amino acids and their salts; methods of making these, and methods of using these.
Krzysztof Darlak, Noriyuki Kawahata, Sameer Ahmed Athamneh
Filed: 25 Oct 17
Utility
Peptidomimetic Macrocycles
1 Apr 20
The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
Vincent GUERLAVAIS, Noriyuki KAWAHATA
Filed: 5 Sep 19
Utility
Peptidomimetic Macrocycles and Uses Thereof
18 Mar 20
Methods for treating solid tumor, determined to lack a p53 deactivation mutation, in a subject are provided.
Hubert CHEN, David Allen ANNIS, Yong CHANG, Manuel AIVADO, Karen OLSON, Chris VIAU
Filed: 5 Sep 19
Utility
Peptidomimetic Macrocycles and Uses Thereof
5 Feb 20
The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition.
Manuel AIVADO, Vincent GUERLAVAIS, Karen OLSON, David Allen ANNIS
Filed: 22 Jul 19
Utility
Peptidomimetic Macrocycles
13 Nov 19
Provided herein are peptidomimetic macrocycles containing amino acid sequences with at least two modified amino acids that form an intramolecular cross-link that can help to stabilize a secondary structure of the amino acid sequence.
Vincent GUERLAVAIS, Carl ELKIN, Huw M. NASH, Tomi K. SAWYER, Bradford J. GRAVES, Eric FEYFANT
Filed: 17 Dec 18