7 patents
Utility
Peptidomimetic macrocycles and uses thereof
17 Aug 21
The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition.
Manuel Aivado, Vincent Guerlavais, Karen Olson, David Allen Annis
Filed: 23 Jul 19
Utility
Peptidomimetic macrocycles
18 May 21
The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
Vincent Guerlavais, Noriyuki Kawahata
Filed: 6 Sep 19
Utility
Peptidomimetic macrocycles
6 Apr 21
Provided herein are peptidomimetic macrocycles containing amino acid sequences with at least two modified amino acids that form an intramolecular cross-link that can help to stabilize a secondary structure of the amino acid sequence.
Vincent Guerlavais, Carl Elkin, Huw M. Nash, Tomi K. Sawyer, Bradford J. Graves, Eric Feyfant
Filed: 18 Dec 18
Utility
Peptidomimetic macrocycles and formulations thereof
2 Feb 21
Aqueous pharmaceutical formulations, for parenteral administration, comprising peptidomimetic macrocycle or a pharmaceutically acceptable salt thereof wherein the peptidomimetic macrocycle binds to MDM2 and/or MDMX proteins are disclosed.
David Allen Annis, Krzysztof Darlak, Chris Rhodes, Sonoko Kanai, Joerg Hoernschemeyer, Michaela Grass
Filed: 24 Sep 15
Utility
Peptidomimetic macrocycles
6 Jul 20
The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
Vincent Guerlavais, Noriyuki Kawahata
Filed: 9 Sep 18
Utility
Disubstituted amino acids and methods of preparation and use thereof
1 Jun 20
Provided are crystalline α, α-disubstituted amino acids and their crystalline salts containing a terminal alkene on one of their side chains, as well as optionally crystalline halogenated and deuterated analogs of the α, α-disubstituted amino acids and their salts; methods of making these, and methods of using these.
Krzysztof Darlak, Noriyuki Kawahata, Sameer Ahmed Athamneh
Filed: 25 Oct 17
Utility
Peptidomimetic macrocycles and uses thereof
11 Nov 19
Methods for treating solid tumor, determined to lack a p53 deactivation mutation, in a subject are provided.
Hubert Chen, David Allen Annis, Yong Chang, Manuel Aivado, Karen Olson, Chris J. Viau
Filed: 23 Sep 15
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