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BMY Bristol-Myers Squibb

GRANT
Utility
Modified relaxin polypeptides comprising a pharmacokinetic enhancer and pharmaceutical compositions thereof
18 Jan 22
The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.
Gene M. Dubowchik, Olafur S. Gudmundsson, Xiaojun Han, R. Michael Lawrence, Dasa Lipovsek, Cort S. Madsen, Claudio Mapelli, Paul E. Morin, Michael C. Myers
Filed: 11 Mar 21
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Utility
Process for preparing indole carboxamide compounds
11 Jan 22
Junying Fan, Peng Geng, Neil A. Strotman, Alina Borovika, Jason Michael Stevens, Dimitri Skliar
Filed: 31 Aug 17
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Utility
Treatment of
11 Jan 22
The present disclosure provides a method for treating a subject afflicted with Waldenström's macroglobulinemia (WM) comprising administering to the subject a therapeutically effective amount of an antibody or an antigen-binding portion thereof that specifically binds to a CXCR4 receptor expressed on the surface of a WM cell.
Irene M. Ghobrial, Aldo M. Roccaro, Josephine M. Cardarelli, Antonio Sacco
Filed: 8 Feb 19
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Utility
Antagonistic anti-CD40 antibodies and methods of antagonizing CD40 activity
11 Jan 22
The disclosure provides for antibodies that bind CD40, including a humanized antibody and a chimeric antibody with different Fc domains.
Aaron Yamniuk, Mary Struthers, Suzanne J. Suchard
Filed: 24 May 18
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Utility
Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR)
4 Jan 22
Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR).
Changyu Wang, Nils Lonberg, Alan J. Korman, Mark J. Selby, Mohan Srinivasan, Karla A. Henning, Michelle Minhua Han, Guodong Chen, Richard Y. Huang, Indrani Chakraborty, Haichun Huang, Susan Chien-Szu Wong, Huiming Li, Bryan C. Barnhart, Aaron P. Yamniuk, Ming Lei, Liang Schweizer, Sandra V. Hatcher, Arvind Rajpal
Filed: 17 Nov 16
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Utility
Additive systems for use in protein PEGylation
4 Jan 22
The present disclosure provides an additive system for use in protein PEGylation.
Matthew R. Hickey, Antonio Ramirez
Filed: 21 Feb 20
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Utility
Histone demethylase inhibitors
4 Jan 22
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease.
Young K. Chen, Toufike Kanouni, Zhe Nie, Jeffrey Alan Stafford, James Marvin Veal, Michael Brennan Wallace
Filed: 18 Sep 20
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Utility
Sphingosine 1 phosphate receptor agonists for neuroprotection
28 Dec 21
Kristen R. Taylor Meadows, Brett Skolnick, Deepak Dalvie
Filed: 8 May 18
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Utility
Anti-ICOS agonist antibodies and uses thereof
28 Dec 21
The present invention provides isolated monoclonal antibodies (e.g., humanized and human monoclonal antibodies) that bind to human Inducible T Cell COStimulator (ICOS) and exhibit therapeutically desirable functional properties, e.g., the ability to stimulate human ICOS activity.
John J. Engelhardt, Mark J. Selby, Alan J. Korman, Mary Diane Feingersh, Brenda L. Stevens
Filed: 13 Mar 19
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Utility
Cytokine profiling analysis
28 Dec 21
This invention relates to methods for predicting a prognosis of a patient with cancer in need of an anti-cancer treatment comprising measuring a cytokine score from a sample obtained from the patient.
Benedetto Farsaci
Filed: 5 Apr 17
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Utility
Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
21 Dec 21
Steven P. Seitz, Emily Charlotte Cherney, Xiao Zhu
Filed: 8 Oct 18
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Utility
Serum albumin-binding fibronectin type III domains
21 Dec 21
The present invention relates to polypeptides which include tenth fibronectin type III domains (10Fn3) that binds to serum albumin, with south pole loop substitutions.
Tracy S. Mitchell, Michael L. Gosselin, Dasa Lipovsek, Rex Parker, Ray Camphausen, Jonathan H. Davis, David Fabrizio
Filed: 23 Aug 19
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Utility
Heteroaryl inhibitors of PAD4
14 Dec 21
The present invention provides compounds useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.
Rajesh Devraj, Gnanasambandam Kumaravel, Holly Atton, Edward Beaumont, Elise Gadouleau, Laura Gleave, Philip Stephen Kerry, Cristina Lecci, Mirco Meniconi, Nat Monck, Jordan Palfrey, Kostas Papadopoulos, Heather Tye, Philip A. Woods
Filed: 22 Feb 17
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Utility
Diazaspiro ROCK inhibitors
7 Dec 21
Yeheng Zhu, Sunita V. Dewnani, William R. Ewing
Filed: 1 Nov 18
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Utility
Method of treating cardiovascular disease and heart failure with modified relaxin polypeptides
30 Nov 21
The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.
Gene M. Dubowchik, Olafur S. Gudmundsson, Xiaojun Han, R. Michael Lawrence, Dasa Lipovsek, Cort S. Madsen, Claudio Mapelli, Paul E. Morin, Michael C. Myers
Filed: 27 Feb 19
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Utility
Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
30 Nov 21
Nicholas R. Wurtz, Pravin Sudhakar Shirude, Andrew Quoc Viet
Filed: 8 Jun 18
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Utility
Dimethoxyphenyl substituted indole compounds as TLR7, TLR8 or TLR9 inhibitors
23 Nov 21
Alaric J. Dyckman, Dharmpal S. Dodd, Christopher P. Mussari, Tasir S. Haque, Michael A. Poss, Louis J. Lombardo, John E. Macor, Laxman Pasunoori, Sreekantha Ratna Kumar
Filed: 27 Jul 17
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Utility
Cyclopropyl urea formyl peptide 2 receptor and formyl peptide 1 receptor agonists
23 Nov 21
Joanne M. Smallheer, Nicholas R. Wurtz, Meriah Neissel Valente, Karen A. Rossi, Ellen K. Kick
Filed: 8 Jun 18
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Utility
Isoxazole o-linked carbamoyl cyclohexyl acids as LPA antagonists
23 Nov 21
Peter Tai Wah Cheng, Robert F. Kaltenbach, III, Hao Zhang, Yan Shi, Jun Li
Filed: 18 Dec 18
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Utility
Antibody polypeptides that antagonize CD40L
23 Nov 21
Antibody polypeptides that specifically bind human CD40L are provided.
Steven G. Nadler, James K. Tamura, Laura Price, Robert P. Rehfuss, Suzanne J. Suchard, Anish Suri, James William Bryson, Aaron Yamniuk, Steven Grant, Olga Ignatovich, Philip Drew
Filed: 12 Dec 18
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