421 patents
Page 10 of 22
Utility
Substituted bicyclic compounds as farnesoid X receptor modulators
22 Feb 22
Dean A. Wacker, Susheel Jethanand Nara, Srinivas Cheruku, Kandhasamy Sarkunam, Firoz Ali Jaipuri, Soodamani Thangavel, Srinivas Jogi, Pavan Kalyan Kathi
Filed: 13 Feb 20
Utility
Process for the preparation of N-((1R,2S,5R)-5-(
22 Feb 22
Burcu Selin Aytar, Alina Borovika, Collin Chan, Joerg Deerberg, Nathan R. Domagalski, Martin D. Eastgate, Yu Fan, Michael David Bengt Fenster, Robert V. Forest, Francisco Gonzalez-Bobes, Rebecca A. Green, Matthew R. Hickey, Nathaniel David Kopp, Thomas E. La Cruz, Kathleen Lauser, Hong Geun Lee, David K. Leahy, Helen Y. Luo, Thomas M. Razler, Scott A. Savage, Chris Sfouggatakis, Maxime C. D. Soumeillant, Serge Zaretsky, Bin Zheng, Ye Zhu
Filed: 19 Jul 18
Utility
Methods of treatment using IL-23p19 monoclonal antibodies
22 Feb 22
The present invention relates to antagonizing the activity of IL-17A, IL-17F and IL-23 using bispecific antibodies that comprise a binding entity that is cross-reactive for IL-17A and IL-17F and a binding entity that binds IL-23p19.
Brenda L. Stevens, Mark W. Rixon, Scott R. Presnell
Filed: 10 Jun 19
Utility
Antagonistic CD40 monoclonal antibodies and uses in treating immune responses
22 Feb 22
The disclosure provides for antibodies that bind CD40, including a humanized antibody.
Aaron Yamniuk, Mary Struthers, Stanley R. Krystek, Jr., Akbar Nayeem, Ginger Rakestraw
Filed: 26 Oct 20
Utility
Methods of treating diseases associated with fibrosis using modified FGF-21 polypeptides
15 Feb 22
Modified FGF-21 polypeptides and uses thereof are provided, for example, for the treatment of diseases associated with fibrosis.
Paul E. Morin, Daniel Cohen, Ranjan Mukherjee, Timothy P. Reilly, Rose C. Christian, Dasa Lipovsek, Ray Camphausen, John Krupinski
Filed: 28 Jun 19
Utility
Methods, kits, agents and apparatuses for transduction
15 Feb 22
Provided herein are methods for transducing a plurality of cells in a composition of cells, such as a population of lymphocytes, containing viral particles.
Keenan Bashour, Semih U. Tareen
Filed: 20 Oct 16
Utility
Solid forms of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use
8 Feb 22
Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.
Marie Georges Beauchamps, Robert Hilgraf, Mohit Atul Kothare, Hon-Wah Man, Mark A. Nagy
Filed: 11 Nov 19
Utility
Antibodies against MICA and/or MICB and uses thereof
8 Feb 22
The disclosure provides antibodies that specifically bind human MICA/B and methods of use thereof.
Michelle Renee Kuhne, Alan J. Korman, Haichun Huang, Yiming Yin, Robert F. Graziano, Natalie A. Bezman, Pavel Strop, Richard Y. Huang, Guodong Chen, Mohan Srinivasan, Peter Sung Keun Lee, Gamze Ozlem Camdere
Filed: 22 Mar 19
Utility
Substituted quinolinylcyclohexylpropanamide compounds and improved methods for their preparation
1 Feb 22
The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.
Albert J. Delmonte, Benjamin M. Cohen, Kenneth Joseph Fraunhoffer, Sergei Kolotuchin, Francisco Gonzalez-Bobes, Gregory Louis Beutner, Adam Joseph Freitag, Michael Scott Bultman, Yu Fan, Prantik Maity, Ian Scott Young, Hilary Plake Beck, Maksim Osipov, Jay Patrick Powers, Maureen Kay Reilly, Hunter Paul Shunatona, James Ross Walker, Mikhail Zibinsky
Filed: 29 Jun 18
Utility
Amorphous and crystalline forms of IDO inhibitors
1 Feb 22
The present disclosure relates to amorphous and crystalline forms of (R)-N-(4-chlorophenyl)-2-((1S,4S)-4-(6-fluoro-quinolin-4-yl) cyclohexyl)propanamide and its salts and hydrates, processes for their production, pharmaceutical compositions comprising them, and methods of treatment using them.
Jay Patrick Powers, Hilary Plake Beck, Maksim Osipov, Maureen Kay Reilly, Hunter Paul Shunatona, James Ross Walker, Mikhail Zibinsky, Tamar Rosenbaum, Ian Scott Young, Jennifer Nelson, Petinka Vlahova
Filed: 29 Jun 18
Utility
Methods and compositions for 18F-radiolabeling of biologics
25 Jan 22
The invention relates to water soluble 18F-prosthetic groups and the synthesis and use of 18F-labeled biological molecules containing the 18F-prosthetic groups for imaging various processes within the body, for detecting the location of molecules associated with disease pathology, and for monitoring disease progression are disclosed.
David Donnelly
Filed: 24 Nov 15
Utility
Deuterated analogs of MK2 inhibitors and uses thereof
25 Jan 22
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
John Malona, Sekhar S. Surapaneni
Filed: 15 Mar 18
Utility
Modified relaxin polypeptides comprising a pharmacokinetic enhancer and pharmaceutical compositions thereof
18 Jan 22
The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.
Gene M. Dubowchik, Olafur S. Gudmundsson, Xiaojun Han, R. Michael Lawrence, Dasa Lipovsek, Cort S. Madsen, Claudio Mapelli, Paul E. Morin, Michael C. Myers
Filed: 11 Mar 21
Utility
Process for preparing indole carboxamide compounds
11 Jan 22
Junying Fan, Peng Geng, Neil A. Strotman, Alina Borovika, Jason Michael Stevens, Dimitri Skliar
Filed: 31 Aug 17
Utility
Treatment of
11 Jan 22
The present disclosure provides a method for treating a subject afflicted with Waldenström's macroglobulinemia (WM) comprising administering to the subject a therapeutically effective amount of an antibody or an antigen-binding portion thereof that specifically binds to a CXCR4 receptor expressed on the surface of a WM cell.
Irene M. Ghobrial, Aldo M. Roccaro, Josephine M. Cardarelli, Antonio Sacco
Filed: 8 Feb 19
Utility
Antagonistic anti-CD40 antibodies and methods of antagonizing CD40 activity
11 Jan 22
The disclosure provides for antibodies that bind CD40, including a humanized antibody and a chimeric antibody with different Fc domains.
Aaron Yamniuk, Mary Struthers, Suzanne J. Suchard
Filed: 24 May 18
Utility
Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR)
4 Jan 22
Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR).
Changyu Wang, Nils Lonberg, Alan J. Korman, Mark J. Selby, Mohan Srinivasan, Karla A. Henning, Michelle Minhua Han, Guodong Chen, Richard Y. Huang, Indrani Chakraborty, Haichun Huang, Susan Chien-Szu Wong, Huiming Li, Bryan C. Barnhart, Aaron P. Yamniuk, Ming Lei, Liang Schweizer, Sandra V. Hatcher, Arvind Rajpal
Filed: 17 Nov 16
Utility
Additive systems for use in protein PEGylation
4 Jan 22
The present disclosure provides an additive system for use in protein PEGylation.
Matthew R. Hickey, Antonio Ramirez
Filed: 21 Feb 20
Utility
Histone demethylase inhibitors
4 Jan 22
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease.
Young K. Chen, Toufike Kanouni, Zhe Nie, Jeffrey Alan Stafford, James Marvin Veal, Michael Brennan Wallace
Filed: 18 Sep 20
Utility
Sphingosine 1 phosphate receptor agonists for neuroprotection
28 Dec 21
Kristen R. Taylor Meadows, Brett Skolnick, Deepak Dalvie
Filed: 8 May 18