421 patents
Page 2 of 22
Utility
Antagonistic CD40 monoclonal antibodies and uses thereof
3 Oct 23
The disclosure provides for antibodies that bind CD40, including a humanized antibody.
Aaron Yamniuk, Mary Struthers, Stanley R. Krystek, Jr., Akbar Nayeem, Ginger Rakestraw
Filed: 31 Jan 22
Utility
Triazolopyridinyl compounds as kinase inhibitors
26 Sep 23
Guanglin Luo, Jie Chen, Carolyn Diane Dzierba, David B. Frennesson, Junqing Guo, Amy C. Hart, Xirui Hu, Michael C. Mertzman, Matthew Reiser Patton, Jianliang Shi, Steven H. Spergel, Brian Lee Venables, Yong-Jin Wu, Zili Xiao, Michael G. Yang
Filed: 18 Oct 21
Utility
Method of treating lung cancer
26 Sep 23
This disclosure provides a method for treating a subject afflicted with a tumor derived from a small cell lung cancer, which method comprises administering to the subject an antibody or an antigen-binding portion thereof that specifically binds to a Programmed Death-1 (PD-1) receptor and inhibits PD-1 activity or the combination of (a) an antibody or an antigen-binding portion thereof that specifically binds to a PD-1 receptor and inhibits PD-1 activity; and (b) an antibody or an antigen-binding portion thereof that specifically binds to a Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4) and inhibits CTLA-4 activity.
Marina Tschaika
Filed: 8 Jul 21
Utility
TL1A antibodies and methods of treatment
26 Sep 23
Disclosed are antibodies that bind specifically to the receptor TNF superfamily member 15 (TNFSF15), also known as TL1A.
Achal Mukundrao Pashine, Guodong Chen
Filed: 1 Mar 21
Utility
Heteroaryl compounds useful as MK2 inhibitors
19 Sep 23
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
Jian Guo, John Malona, Alexander L. Ruchelman, Sekhar S. Surapaneni
Filed: 17 Sep 21
Utility
Methods of selecting therapeutic molecules
19 Sep 23
The present disclosure provides methods of using a calcium oscillation assay and/or a sequence score calculation to identify a molecule that is safe for administration.
Richard E. Olson, Angela M. Cacace, Peter Hagedorn, Anja Mølhart Høg, Niels Fisker Nielsen, Dong LI, Jeffrey M. Brown, Stephen E. Mercer, Marianne Lerbech Jensen
Filed: 4 Feb 16
Utility
Methods of antibody production that minimize disulfide bond reduction
19 Sep 23
The present disclosure discloses methods for purifying antibodies providing an air overlay or headspace to single-use storage bags containing the antibody during purification.
John C. Fann, Brian W. O'Mara, Laura R. Smith
Filed: 24 Apr 18
Utility
Supramolecular filamentous assemblies for protein purification
5 Sep 23
The present invention provide novel immunofiber compositions for protein or peptide purification and simple and cost-efficient methods and systems using these compositions.
Honggang Cui, Yi Li, Lye Lin Lock, XuanKuo Xu, Zhengjian Li
Filed: 17 Aug 18
Utility
Histone demethylase inhibitors
22 Aug 23
The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease.
Young K. Chen, Michael Brennan Wallace
Filed: 12 Apr 21
Utility
Compositions comprising an anti-LAG-3 antibody or an anti-LAG-3 antibody and an anti-PD-1 or anti-PD-L1 antibody
15 Aug 23
This provides pharmaceutical compositions that comprise (i) an anti-LAG-3 antibody or antigen binding fragment thereof or (ii) an anti-LAG-3 antibody or antigen binding fragment thereof and an anti-PD-1 antibody, anti-PD-L1 antibody, or antigen binding fragment thereof.
Lori S. Burton, William Ying, Nils Lonberg, Sudhir Chakravarthi, Pedro Smith
Filed: 30 May 18
Utility
Pyridinyl substituted oxoisoindoline compounds
8 Aug 23
Yan Chen, Godwin Kwame Kumi, Audris Huang, Satheesh Kesavan Nair, Bharat Dinkar Shimpukade, Suresh Babu Vishwa Krishna Penmetsa, James Aaron Balog
Filed: 5 Apr 22
Utility
Substituted bicyclic compounds as farnesoid X receptor modulators
1 Aug 23
Dean A. Wacker, Susheel Jethanand Nara, Srinivas Cheruku, Kandhasamy Sarkunam, Firoz Ali Jaipuri, Soodamani Thangavel, Srinivas Jogi, Pavan Kalyan Kathi
Filed: 7 Dec 21
Utility
Substituted naphthyridinone compounds useful as T cell activators
1 Aug 23
Upender Velaparthi, Louis S. Chupak, Chetan Padmakar Darne, Min Ding, Robert G. Gentles, Yazhong Huang, Manjunatha Narayana Rao Kamble, Scott W. Martin, Raju Mannoori, Ivar M. McDonald, Richard E. Olson, Hasibur Rahaman, Prasada Rao Jalagam, Saumya Roy, Gopikishan Tonukunuru, Sivasudar Velaiah, Jayakumar Sankara Warrier, Xiaofan Zheng, John S. Tokarski, Bireshwar Dasgupta, Kotha Rathnakar Reddy, Thiruvenkadam Raja
Filed: 1 Feb 21
Utility
Phenylpyrrolidinone formyl peptide 2 receptor agonists
25 Jul 23
Pravin Sudhakar Shirude, Vishweshwaraiah Baligar, Balaji Seshadri, Amit Kumar Chattopadhyay, Nicholas R. Wurtz, Ellen K. Kick
Filed: 12 Aug 21
Utility
IP-10 antibodies and their uses
25 Jul 23
The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration.
Mohan Srinivasan, Shrikant Deshpande, Qihong Zhao, Huadong Sun, Ginger Rakestraw, Guodong Chen, Richard Y. Huang, Steven Sheriff, Cristian Rodriguez, John P. Throup, Rose A. Dibella
Filed: 27 Dec 19
Utility
Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
25 Jul 23
The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual to treatment of cardiovascular disorders with statin.
Olga Iakoubova, James J. Devlin, Zenta Tsuchihashi, Peter Shaw, Lynn Marie Ploughman, Kim E. Zerba, Koustubh Ranade, Todd Kirchgessner
Filed: 26 Feb 21
Utility
Substituted bicyclic compounds
18 Jul 23
Alaric J. Dyckman, T. G. Murali Dhar, Hai-Yun Xiao, John L. Gilmore, Michael G. Yang, Zili Xiao, David Marcoux
Filed: 4 May 21
Utility
Triazole N-linked carbamoyl cyclohexyl acids as LPA antagonists
11 Jul 23
Yan Shi, Peter Tai Wah Cheng, Ying Wang, Jun Shi, Shiwei Tao, Jun Li, Lawrence J. Kennedy, Robert F. Kaltenbach, III, Hao Zhang, James R. Corte
Filed: 7 Apr 21
Utility
Method of purity determination by capillary electrophoresis
11 Jul 23
Protein separation by capillary electrophoresis using a buffer composition comprising hydrophobic detergents that have alkyl chains longer than 12 carbon atoms.
Jeff W. Beckman, Qian Guan
Filed: 7 Sep 18
Utility
Treatment of cancer with anti-GITR agonist antibodies
27 Jun 23
Provided herein are methods for treating cancer, comprising administering to a subject having cancer a therapeutically effective amount of an anti-GITR antibody alone or together with an anti-PD-1 or anti-PD-L1 antibody.
Suba Krishnan, Penny E. Phillips, Zheng Yang, Haiqing Wang
Filed: 15 May 18