61 patents
Page 3 of 4
Utility
Minimal volume reprogramming of mononuclear cells
23 Mar 21
The invention provides compositions and methods for reprogramming minimal volumes of mononuclear cells.
Peter Flynn, Bahram Valamehr
Filed: 13 Jun 18
Utility
Cell Culture Platform for Single Cell Sorting and Enhanced Reprogramming of Ipscs
18 Mar 21
The invention provides cell culture conditions for culturing stem cells, including feeder-free conditions for generating and culturing human induced pluripotent stem cells (iPSCs).
Bahram Valamehr, Ramzey Abujarour, Peter Flynn
Filed: 30 Sep 20
Utility
Methods and compositions for inducing hematopoietic cell differentiation
16 Mar 21
The invention provides culture platforms, cell media, and methods of differentiating pluripotent cells into hematopoietic cells.
Bahram Valamehr, Raedun Clarke, Ryan Bjordahl
Filed: 2 Oct 20
Utility
Methods and Compositions for Inducing Hematopoietic Cell Differentiation
4 Mar 21
The invention provides culture platforms, cell media, and methods of differentiating pluripotent cells into hematopoietic cells.
Bahram Valamehr, Raedun Clarke, Ryan Bjordahl
Filed: 2 Oct 20
Utility
Enhanced immune effector cells and use thereof
23 Feb 21
Provided are methods and compositions for obtaining functionally enhanced derivative effector cells obtained from directed differentiation of genomically engineered iPSCs.
Bahram Valamehr, Ryan Bjordahl, Jode Goodridge, Tom Tong Lee
Filed: 19 Sep 19
Utility
Methods and Compositions for Inducing Hematopoietic Cell Differentiation
28 Jan 21
The invention provides culture platforms, cell media, and methods of differentiating pluripotent cells into hematopoietic cells.
Bahram Valamehr, Raedun Clarke, Ryan Bjordahl
Filed: 2 Oct 20
Utility
Engineered Immune Effector Cells and Use Thereof
28 Jan 21
Provided are methods and compositions for obtaining functionally enhanced derivative effector cells obtained from directed differentiation of genomically engineered iPSCs.
Bahram VALAMEHR, Ryan BJORDAHL, Jode GOODRIDGE, Tom Tong LEE
Filed: 28 Mar 19
Utility
IMMUNOTHERAPIES USING ENHANCED iPSC DERIVED EFFECTOR CELLS
21 Jan 21
Provided are methods and compositions for obtaining functionally enhanced derivative effector cells obtained from directed differentiation of genomically engineered iPSCs.
Bahram VALAMEHR, Ryan BJORDAHL, Tom Tong LEE, Svetlana GAIDAROVA
Filed: 30 Nov 18
Utility
Methods and compositions for inducing hematopoietic cell differentiation
7 Dec 20
The invention provides culture platforms, cell media, and methods of differentiating pluripotent cells into hematopoietic cells.
Bahram Valamehr, Raedun Clarke, Ryan Bjordahl
Filed: 25 Jul 16
Utility
Cell potency assay for therapeutic potential
30 Nov 20
The invention provides cell potency assays for measuring, determining, identifying, confirming, or validating the therapeutic potential of a cell population.
Daniel Shoemaker, David L. Robbins
Filed: 10 Mar 14
Utility
Cell culture platform for single cell sorting and enhanced reprogramming of iPSCs
23 Nov 20
The invention provides cell culture conditions for culturing stem cells, including feeder-free conditions for generating and culturing human induced pluripotent stem cells (iPSCs).
Bahram Valamehr, Ramzey Abujarour, Peter Flynn
Filed: 29 Jun 17
Utility
Hematopoietic Stem and Progenitor Cell Therapy
28 Oct 20
The invention provides improved methods for cell therapy.
Daniel Shoemaker, Pratik Multani, Caroline Desponts, David L. Robbins, Paul Grayson, John Mendlein
Filed: 10 May 20
Utility
Cellular Reprogramming Using Temporal and Transient Plasmid Vector Expression System
26 Aug 20
Provided are methods and compositions for inducing the reprogramming of a non-pluripotent to an iPSC having desirable properties using a vector system providing transient and temporal expression of transgenes that are short-lived.
Bahram Valamehr, Megan Robinson
Filed: 9 Oct 18
Utility
Methods and Compositions for Inducing Hematopoietic Cell Differentiation
5 Aug 20
The invention provides culture platforms, cell media, and methods of differentiating pluriptent cells into hematopoietic cells.
Bahram Valamehr, Raedun Clarke
Filed: 3 Feb 20
Utility
Compositions and Methods for Immune Cell Modulation In Adoptive Immunotherapies
10 Jun 20
Compounds that either produced a higher proportion or greater absolute number of phenotypically identified naive, stem cell memory, central memory T cells, adaptive NK cells, and type I NKT cells are identified.
Jonathan Rosen, Betsy Denise Rezner, Ian Hardy, Eigen Peralta
Filed: 3 Dec 17
Utility
Compositions and Methods for Immune Cell Modulation In Adoptive Immunotherapies
10 Jun 20
Compounds that either produce a higher proportion or greater absolute number of phenotypically identified naive, stem cell memory, central memory T cells, adaptive NK cells, and type I NKT cells are identified.
Jonathan Rosen, Eigen Peralta, Ian Hardy, Betsy D. Rezner, Christian Maine, Daniel Shoemaker, David Robbins, Lucas Thompson
Filed: 18 Jul 18
Utility
Cells with Increased Immuno-regulatory Properties and Methods for Their Use and Manufacture
3 Jun 20
The present invention is directed to compositions and methods to increase the expression of PD-L1 and/or IDO-1 in a population of cells, the modulated cells expressing increased PD-L1 and/or IDO-1, and methods related to the immunosuppressive effects obtained by cells expressing increased PD-L1 and/or IDO-1.
David Robbins, Betsy Rezner, Leah Mitchell, Lisa Guerrettaz, Philippe Alessandro Parone, Robert Steven Tacke, Kevin Lai, Bahram Valamehr
Filed: 1 Dec 19
Utility
Methods and compositions for inducing hematopoietic cell differentiation
20 Apr 20
The invention provides culture platforms, cell media, and methods of differentiating pluripotent cells into hematopoietic cells.
Bahram Valamehr, Raedun Clarke
Filed: 25 Jan 16
Utility
Composition and Methods for Inducing Myeloid Suppressive Cells and Use Thereof
1 Apr 20
Compositions and methods for manufacturing induced immune regulatory cells comprising induced myeloid suppressive cells including MDSCs (myeloid-derived suppressor cells), dendritic cells, macrophages, and subpopulations thereof are provided.
Philippe A. Parone, Robert S. Tacke, Bahram Valamehr, Daniel Shoemaker, Martin Hosking, Lisa Guerrettaz
Filed: 12 Jun 18
Utility
Genomic Engineering of Pluripotent Cells
25 Mar 20
Provided are methods and compositions for obtaining genome-engineered iPSCs, and derivative cells with stable and functional genome editing at selected sites.
Bahram VALAMEHR, Ramzey ABUJAROUR, Tom Tong LEE, Weijie LAN, Raedun CLARKE, Ryan BJORDAHL
Filed: 16 Oct 19