41 patents
Utility
Chimeric Antigen Receptor for Tumor Targeting
4 Jan 24
Provided are chimeric antigen receptors (CAR) specific to a selected tumor antigen.
Bahram VALAMEHR, Tom Tong LEE, Martin HOSKING, Susumu YAMAMOTO, Tatsuo MAEDA
Filed: 30 Jun 23
Utility
Engineered Ipsc and Immune Effector Cells for Heterogenous Tumor Control
21 Dec 23
Provided are methods and compositions for obtaining functionally enhanced derivative effector cells obtained from directed differentiation of genomically engineered iPSCs.
Bahram VALAMEHR, Martin HOSKING, Tom Tong LEE, John Charles GOULDING
Filed: 4 Nov 21
Utility
Engineered Ipsc and Persistent Immune Effector Cells
7 Dec 23
Provided are methods and compositions for obtaining functionally enhanced derivative effector cells obtained from directed differentiation of genomically engineered iPSCs.
Bahram VALAMEHR, Eigen PERALTA, Chia-Wei CHANG
Filed: 4 Nov 21
Utility
Multiplexed Engineered Ipscs and Immune Effector Cells Targeting Solid Tumors
30 Nov 23
Provided are methods and compositions for obtaining functionally enhanced derivative effector cells obtained from directed differentiation of genomically engineered iPSCs.
Bahram VALAMEHR, Tom T. LEE, Bi-Huei YANG, Mochtar PRIBADI, Chia-Wei CHANG
Filed: 4 Nov 21
Utility
Cells Having Solid Tumor Targeting Backbone and Use Thereof
9 Nov 23
Provided are methods and compositions for obtaining functionally enhanced derivative effector cells obtained from directed differentiation of genomically engineered iPSCs.
Bahram VALAMEHR, Tom Tong LEE, Martin HOSKING, Eigen PERALTA, Chia-Wei CHANG
Filed: 30 Jun 23
Utility
Combining Ipsc Derived Effector Cell Types for Immunotherapy Use
27 Jul 23
Provided are methods and compositions for obtaining functionally enhanced derivative effector cells obtained from directed differentiation of genomically engineered iPSCs.
Bahram VALAMEHR, Jode GOODRIDGE, Ryan BJORDAHL
Filed: 18 Jun 21
Utility
Methods and Compositions for Inducing Hematopoietic Cell Differentiation
6 Jul 23
The invention provides culture platforms, cell media, and methods of differentiating pluriptent cells into hematopoietic cells.
Bahram VALAMEHR, Raedun CLARKE
Filed: 14 Mar 23
Utility
ENHANCEMENT OF iPSC-DERIVED EFFECTOR IMMUNE CELL USING SMALL COMPOUNDS
19 Jan 23
Provided are methods and compositions for obtaining functionally enhanced derivative effector cells obtained from directed differentiation of genomically engineered iPSCs.
Bahram VALAMEHR, Ryan BJORDAHL, Jode GOODRIDGE, Mili MANDAL, Chia-Wei CHANG
Filed: 4 Dec 20
Utility
Compositions and Methods for Immune Cell Modulation In Adoptive Immunotherapies
22 Dec 22
Compounds that either produced a higher proportion or greater absolute number of phenotypically identified nave, stem cell memory, central memory T cells, adaptive NK cells, and type I NKT cells are identified.
Jonathan ROSEN, Betsy REZNER, Bahram VALAMEHR, Ryan BJORDAHL, Eigen PERALTA, Ian HARDY
Filed: 8 Jul 22
Utility
Multi-targeting Effector Cells and Use Thereof
1 Dec 22
Provided are methods and compositions for obtaining functionally enhanced derivative effector cells obtained from directed differentiation of genomically engineered iPSCs.
Bahram VALAMEHR, Ryan BJORDAHL, Jode GOODRIDGE, Tom Tong LEE
Filed: 25 Sep 20
Utility
Platform for the Induction & Maintenance of Ground State Pluripotency
13 Oct 22
The invention provides compositions and methods for manufacturing pluripotent cells.
Bahram VALAMEHR, Megan ROBINSON, Ramzey ABUJAROUR
Filed: 27 Apr 22
Utility
Immune Effector Cell Engineering and Use Thereof
1 Sep 22
Provided are methods and compositions for obtaining functionally enhanced derivative effector cells obtained from directed differentiation of genomically engineered iPSCs.
Bahram VALAMEHR, Tom Tong LEE, Ryan BJORDAHL, Jode GOODRIDGE
Filed: 17 Jul 20
Utility
Reprogramming Methods and Cell Culture Platforms
21 Jul 22
The invention provides compositions and methods for manufacturing pluripotent cells.
Bahram VALAMEHR, Peter FLYNN, Ramzey ABUJAROUR, Megan ROBINSON
Filed: 19 Jan 22
Utility
CD3 RECONSTITUTION IN ENGINEERED iPSC AND IMMUNE EFFECTOR CELLS
16 Jun 22
Provided are methods and compositions for obtaining functionally enhanced derivative effector cells obtained from directed differentiation of genomically engineered iPSCs.
Bahram VALAMEHR, Tom Tong LEE, Alec WITTY, Mochtar PRIBADI
Filed: 8 Apr 20
Utility
IMMUNOTHERAPIES USING ENHANCED iPSC DERIVED EFFECTOR CELLS
28 Apr 22
Provided are methods and compositions for obtaining functionally enhanced derivative effector cells obtained from directed differentiation of genomically engineered iPSCs.
Bahram VALAMEHR, Ryan BJORDAHL, Tom Tong LEE
Filed: 25 Nov 19
Utility
Enhanced Stem Cell Composition
21 Apr 22
The invention provides improved methods for cell therapy.
Daniel Shoemaker, David Robbins, John D. Mendlein, Caroline Desponts
Filed: 4 Jun 21
Utility
Methods of Treating Ischemia
24 Feb 22
The invention provides compositions comprising stem and/or progenitor cells that have been treated to enhance the therapeutic properties of the cells for treating ischemia.
Dan Shoemaker, Pratik S. Multani, John D. Mendlein, David Robbins
Filed: 12 Apr 21
Utility
Compositions and Methods for Immune Cell Modulation In Adoptive Immunotherapies
23 Dec 21
Compounds that either produced a higher proportion or greater absolute number of phenotypically identified nave, stem cell memory, central memory T cells, adaptive NK cells, and type I NKT cells are identified.
Jonathan Rosen, Betsy Rezner, Bahram Valamehr, Ryan Bjordahl, Eigen Peralta
Filed: 7 Jul 21
Utility
Cell Potency Assay for Therapeutic Potential
4 Nov 21
The invention provides cell potency assays for measuring, determining, identifying, confirming, or validating the therapeutic potential of a cell population.
Daniel Shoemaker, David L. Robbins
Filed: 12 Nov 20
Utility
Genomic Engineering of Pluripotent Cells
21 Oct 21
Provided are methods and compositions for obtaining genome-engineered iPSCs, and derivative cells with stable and functional genome editing at selected sites.
Bahram VALAMEHR, Ramzey ABUJAROUR, Tom Tong LEE, Weijie LAN, Raedun CLARKE, Ryan BJORDAHL
Filed: 22 Apr 21