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MRSN Mersana Therapeutics

GRANT
Utility
Sting agonist compounds and methods of use
26 Oct 21
The present disclosure relates to STING (Stimulator of Interferon Genes) agonist compounds, methods of making the compounds and their methods of use.
Jeremy R. Duvall, Keith W. Bentley, Brian D. Jones, Eugene W. Kelleher, Soumya S. Ray, Joshua D. Thomas, Dorin Toader
Filed: 31 Jul 20
GRANT
Utility
Peptide-containing linkers for antibody-drug conjugates
5 Oct 21
The present disclosure relates generally to antibody-drug conjugates comprising peptide-containing linkers and to methods of using these conjugates as therapeutics and/or diagnostics.
Aleksandr V. Yurkovetskiy, Natalya D. Bodyak, Bingfan Du, Dmitry R. Gumerov, Mariya Kozytska, Timothy B. Lowinger, Cheri A. Stevenson, Mao Yin
Filed: 21 Nov 17
APP
Utility
NAPI2B-TARGETED Antibody-drug Conjugates and Methods of Use Thereof
30 Sep 21
This disclosure provides NaPi2b-targeted antibody-drug conjugates (e.g., NaPi2b-targeted antibody-polymer-drug conjugates) that specifically bind to the extracellular region of SLC34A2, and to methods of using such conjugates in a variety of therapeutic, diagnostic, and prophylactic indications.
Donald A. BERGSTROM, Natalya D. BODYAK, Timothy B. LOWINGER, Peter U. PARK, Laura L. POLING, Aleksandr V. YURKOVETSKIY
Filed: 20 Jan 21
APP
Utility
Site Specific Antibody-drug Conjugates with Peptide-containing Linkers
22 Jul 21
The present disclosure relates generally to antibody-drug conjugates comprising peptide-containing linkers and to methods of using these conjugates as therapeutics and/or diagnostics.
Timothy B. LOWINGER, Marc I. DAMELIN, Dorin TOADER
Filed: 8 Jan 21
GRANT
Utility
NaPi2b-targeted antibody-drug conjugates and methods of use thereof
16 Mar 21
This disclosure provides NaPi2b-targeted antibody-drug conjugates (e.g., NaPi2b-targeted antibody-polymer-drug conjugates) that specifically bind to the extracellular region of SLC34A2, and to methods of using such conjugates in a variety of therapeutic, diagnostic, and prophylactic indications.
Donald A. Bergstrom, Natalya D. Bodyak, Timothy B. Lowinger, Peter U. Park, Laura L. Poling, Aleksandr V. Yurkovetskiy
Filed: 13 Mar 17
APP
Utility
Sting Agonist Compounds and Methods of Use
4 Feb 21
The present disclosure relates to STING (Stimulator of Interferon Genes) agonist compounds, methods of making the compounds and their methods of use.
Jeremy R. DUVALL, Keith W. BENTLEY, Brian D. JONES, Eugene W. KELLEHER, Soumya S. RAY, Joshua D. THOMAS, Dorin TOADER
Filed: 31 Jul 20
GRANT
Utility
Methods of producing drug-carrying polymer scaffolds and protein-polymer-drug conjugates
14 Sep 20
The disclosure provides methods of synthesis of polymeric scaffolds, e.g., those useful for conjugating with a protein based recognition-molecule (PBRM) to form PBRM-polymer-drug conjugates, and PBRM-polymer-drug conjugates thereof.
Venu Reddy Gurijala, Satyanarayan Reddy Bollu, Jacques Leblanc, Timothy B. Lowinger, Dennis McGillicuddy, Mao Yin, Aleksandr V. Yurkovetskiy
Filed: 21 Jun 18
GRANT
Utility
Pyrrolobenzodiazepines and conjugates thereof
25 May 20
The present disclosure relates generally to derivatives of pyrrolobenzodiazepines and antibody-drug conjugates thereof and to methods of using these conjugates as therapeutics and/or diagnostics.
Mao Yin, Joshua D. Thomas, Aleksandr V. Yurkovetskiy, Patrick R. Conlon, Bingfan Du, Eugene W. Kelleher, Timothy B. Lowinger, Shuyi Tang
Filed: 5 Nov 18
GRANT
Utility
Protein-polymer-drug conjugates
30 Mar 20
A drug conjugate is provided herein.
Aleksandr V. Yurkovetskiy, Mao Yin, Timothy B. Lowinger, Joshua D. Thomas, Charles E. Hammond, Cheri A. Stevenson, Natalya D. Bodyak, Patrick R. Conlon, Dmitry R. Gumerov
Filed: 21 Aug 17
APP
Utility
NaPi2B-TARGETED POLYMER ANTIBODY-DRUG CONJUGATES AND METHODS OF USE THEREOF
19 Feb 20
Disclose herein are dosing regimens for targeted NaPi2b antibody-drug conjugates for treating cancer.
Eric P. HAILMAN, Donna M. JARLENSKI, Donald A. BERGSTROM
Filed: 15 Aug 19
APP
Utility
Monoclonal Antibodies Against HER2 Epitope and Methods of Use Thereof
29 Jan 20
This invention provides fully human monoclonal antibodies that recognize HER2.
Natalya D. BODYAK, Michael J. DeVIT, Eric M. KRAULAND, Timothy B. LOWINGER, Peter U. PARK, Bianka PRINZ, Aleksandr V. YURKOVETSKIY
Filed: 1 Oct 19
GRANT
Utility
Protein-polymer-drug conjugates
20 Jan 20
Auristatin compounds and conjugates thereof are provided herein.
Aleksandr V. Yurkovetskiy, Mao Yin, Timothy B. Lowinger, Joshua D. Thomas, Charles E. Hammond, Cheri A. Stevenson, Natalya D. Bodyak, Patrick R. Conlon, Dmitry R. Gumerov
Filed: 21 Feb 18
GRANT
Utility
Pyrrolobenzodiazepines and conjugates thereof
6 Jan 20
The present disclosure relates generally to derivatives of pyrrolobenzodiazepines and antibody-drug conjugates thereof and to methods of using these conjugates as therapeutics and/or diagnostics.
Joshua D. Thomas, Mao Yin, Aleksandr V. Yurkovetskiy, Patrick R. Conlon, Ahmed Hilmy, Eugene W. Kelleher, Timothy B. Lowinger, Cheri A. Stevenson, Shuyi Tang
Filed: 21 Jun 17
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