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ABUS Arbutus Biopharma

APP
Utility
Lipid Nanoparticle Formulations
6 Jan 22
The invention provides certain specific lipid nanoparticles comprising: (a) one or more nucleic acid molecules; (b) cholesterol; (c) DSPC; (d) PEG-C-DMA; and (e) a cationic lipid; and pharmaceutical compositions comprising the lipid nanoparticles.
James HEYES, Adam JUDGE, Kieu Mong LAM, Lorne Ralph PALMER, Petra SCHREINER
Filed: 8 Nov 19
APP
Utility
Lipid Nanoparticle Formulations
6 Jan 22
The invention provides certain specific lipid nanoparticles comprising: (a) one or more nucleic acid molecules; (b) cholesterol; (c) DSPC; (d) PEG-C-DMA; and (b) a cationic lipid of formula CL1 or CL2, and pharmaceutical compositions comprising the lipid nanoparticles.
Kieu Mong LAM, Alan D. MARTIN, Petra SCHREINER
Filed: 8 Nov 19
GRANT
Utility
Compositions and methods for delivering messenger RNA
7 Dec 21
The present invention provides compositions comprising nucleic acid molecules, such as mRNA molecules, encapsulated within lipid particles.
Michael J. Abrams, James Heyes, Adam Judge, Kieu Mong Lam, Lorne Ralph Palmer, Stephen P. Reid, Edward D. Yaworski
Filed: 30 Jun 17
GRANT
Utility
Lipid formulations for nucleic acid delivery
12 Oct 21
The present invention provides novel, stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles.
Edward Yaworski, Kieu Lam, Lloyd Jeffs, Lorne Palmer, Ian MacLachlan
Filed: 12 Apr 21
GRANT
Utility
Substituted 2,3-dihydro-1H-indene analogs and methods using same
28 Sep 21
The present invention includes substituted 2,3-dihydro-1H-indene analogs, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient.
Yingzhi Bi, Bruce D. Dorsey, Christopher Brooks Moore
Filed: 24 Apr 18
APP
Utility
ANTI-PD-1 Antibodies, or Fragments Thereof, for Treating Hepatitis B
16 Sep 21
Certain embodiments of the invention provide a method for treating a Hepatitis B virus infection and/or ameliorating one or more symptoms associated with a Hepatitis B virus infection in a mammal, the method comprising the step of administering to the mammal a therapeutically effective amount of an anti-PD-1 antibody, or fragment thereof.
Christopher Brooks MOORE, Jang-June PARK
Filed: 21 Aug 17
APP
Utility
Liposomal Apparatus and Manufacturing Methods
9 Sep 21
The present invention provides apparatus and processes for producing liposomes.
Ian MacLachlan, Lloyd B. Jeffs, Lorne R. Palmer, Cory Giesbrecht
Filed: 25 May 21
APP
Utility
Liposomal Apparatus and Manufacturing Methods
9 Sep 21
The present invention provides apparatus and processes for producing liposomes.
Ian MacLachlan, Lloyd B. Jeffs, Lorne R. Palmer, Cory Giesbrecht
Filed: 25 May 21
APP
Utility
Liposomal Apparatus and Manufacturing Methods
2 Sep 21
The present invention provides apparatus and processes for producing liposomes.
Ian MacLachlan, Lloyd B. Jeffs, Lorne R. Palmer, Cory Giesbrecht
Filed: 16 Mar 21
APP
Utility
Novel Lipid Formulations for Nucleic Acid Delivery
2 Sep 21
The present invention provides novel, stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles.
Edward Yaworski, Kieu Lam, Lloyd Jeffs, Lorne Palmer, Ian MacLachlan
Filed: 12 Apr 21
GRANT
Utility
Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same
24 Aug 21
The present invention includes novel substituted bicyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient.
Andrew G. Cole, Bruce D. Dorsey, Ramesh Kakarla, Steven Kultgen, Jorge Quintero
Filed: 20 Mar 18
APP
Utility
Substituted 2,2'-BIPYRIMIDINYL Compounds, Analogues Thereof, and Methods Using Same
19 Aug 21
The present disclosure includes substituted 2,2′-bipyrimidinyl compounds, analogues thereof, and compositions comprising the same, which can be used to treat and/or prevent hepatitis B virus (HBV) and/or hepatitis B virus (HBV)-hepatitis D virus (HDV) infection in a patient.
Shuai Chen, Andrew G. Cole, Bruce D. Dorsey, Benjamin J. Dugan, Yi Fan, Dimitar B. Gotchev, Ramesh Kakarla, Jorge Quintero, Michael J. Sofia
Filed: 14 May 19
GRANT
Utility
Lipids and compositions for the delivery of therapeutics
3 Aug 21
Muthiah Manoharan, Muthusamy Jayaraman, Kallanthottathil G. Rajeev, Laxman Eltepu, Steven Ansell, Jianxin Chen
Filed: 8 Jun 17
APP
Utility
Novel Lipid Formulations for Nucleic Acid Delivery
22 Jul 21
The present invention provides novel, stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles.
Edward Yaworski, Kieu Lam, Lloyd Jeffs, Lorne Palmer, Ian MacLachlan
Filed: 10 Nov 20
APP
Utility
Non-liposomal Systems for Nucleic Acid Delivery
8 Jul 21
The present invention provides novel, stable lipid particles having a non-lamellar structure and comprising one or more active agents or therapeutic agents, methods of making such lipid particles, and methods of delivering and/or administering such lipid particles.
Ed Yaworski, Lloyd B. Jeffs, Lorne R. Palmer
Filed: 16 Mar 21
APP
Utility
Substituted Tetrahydrocyclopenta[c]pyrroles, Substituted Dihydropyrrolizines, Analogues Thereof, and Methods Using Same
17 Jun 21
The present invention includes novel substituted bicyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection and/or hepatitis D virus (HDV) infection in a patient.
Andrew G. COLE, Steven KULTGEN
Filed: 25 Jul 19
APP
Utility
Novel Lipids and Compositions for the Delivery of Therapeutics
3 Jun 21
Muthiah Manoharan, Kallanthottathil G. Rajeev, Muthusamy Jayaraman, David Butler, Jayaprakash K. Nair, Martin Maier, Laxman Eltepu
Filed: 7 Oct 20
GRANT
Utility
Substituted pyridinone-containing trycyclic compounds, and methods using same
25 May 21
The present invention includes substituted pyridinone-containing tricyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection in a patient.
Laurèn Danielle Bailey, Yingzhi Bi, Shuai Chen, Bruce D. Dorsey, Dimitar B. Gotchev, Richard James Holland, Ramesh Kakarla, Duyan Nguyen, Mark Christopher Wood
Filed: 30 Mar 20
GRANT
Utility
Substituted chromane-8-carboxamide compounds and analogues thereof, and methods using same
11 May 21
The present invention includes novel substituted bicyclic (such as 4-substituted-chromane-8-carboxamide compounds), and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient.
Andrew G. Cole, Steven Kultgen
Filed: 13 Sep 17
GRANT
Utility
Lipid compositions
23 Mar 21
Muthiah Manoharan, Kallanthottathil G. Rajeev, Muthusamy Jayaraman, David Butler, Michael E. Jung
Filed: 4 Oct 19
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