28 patents
Utility
Lipid formulations for delivery of therapeutic agents
17 Oct 23
The present invention provides novel, serum-stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles.
Ed Yaworski, Stephen Reid, James Heyes, Adam Judge, Ian MacLachlan
Filed: 25 Jul 22
Utility
Non-liposomal systems for nucleic acid delivery
8 Aug 23
The present invention provides novel, stable lipid particles having a non-lamellar structure and comprising one or more active agents or therapeutic agents, methods of making such lipid particles, and methods of delivering and/or administering such lipid particles.
Ed Yaworski, Lloyd B. Jeffs, Lorne R. Palmer
Filed: 16 Mar 21
Utility
Lipids and compositions for the delivery of therapeutics
1 Aug 23
Muthiah Mancharan, Muthusamy Jayaraman, Kallanthottathil G. Rajeev, Laxman Eltepu, Steven Ansell, Jianxin Chen
Filed: 24 Jun 21
Utility
Substituted 2-pyridone tricyclic compounds, analogues thereof, and methods using same
18 Jul 23
Shuai Chen, Bruce D. Dorsey, Yi Fan, Dimitar B. Gotchev, Jorge Quintero
Filed: 11 Mar 19
Utility
Substituted tetrahydrocyclopenta[C]pyrroles, substituted dihydropyrrolizines, analogues thereof, and methods using same
31 Jan 23
The present invention includes novel substituted bicyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection and/or hepatitis D virus (HDV) infection in a patient.
Andrew G. Cole, Steven Kultgen
Filed: 25 Jul 19
Utility
Methods for preparing substituted pyridinone-containing tricyclic compounds
22 Nov 22
The present disclosure relates to novel, scalable methods of making substituted tricyclic compounds that are useful to treat and/or prevent HBV and/or HBV-HDV infection and related conditions in a subject.
Shuai Chen, Bruce D. Dorsey, Dimitar B. Gotchev, Duyan Nguyen, Mahesh Kumar Pallerla, Ganapati Reddy Pamulapati
Filed: 11 Apr 19
Utility
Lipid formulations for delivery of therapeutic agents
20 Sep 22
The present invention provides novel, serum-stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles.
Ed Yaworski, Stephen Reid, James Heyes, Adam Judge, Ian MacLachlan
Filed: 22 Aug 18
Utility
Targeted compositions
30 Aug 22
The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups.
James Heyes, Richard J. Holland, Adam Judge, Amy C. H. Lee, Alan D. Martin, Nicholas Michael Snead, Emily P. Thi, Mark Wood, Xin Ye
Filed: 10 Apr 18
Utility
Lipid containing formulations
23 Aug 22
Compositions and methods useful in administering nucleic acid based therapies, for example association complexes such as liposomes and lipoplexes are described.
Muthiah Manoharan, Kallanthottathil G. Rajeev, Akin Akinc, Jayaprakash K. Nair, Muthusamy Jayaraman, Martin Maier
Filed: 13 Dec 19
Utility
Trialkyl cationic lipids and methods of use thereof
26 Jul 22
The present invention provides compositions and methods for the delivery of therapeutic agents to cells.
James Heyes, Mark Wood, Alan Martin
Filed: 30 Jan 20
Utility
Methods for ameliorating infusion reactions
7 Jun 22
Certain embodiments of the invention provide methods of ameliorating an infusion reaction in a mammal in need thereof.
Jeffrey P. Bechard, Wayne J. Wallis
Filed: 20 Dec 17
Utility
Liposomal apparatus and manufacturing methods
3 May 22
The present invention provides apparatus and processes for producing liposomes.
Ian MacLachlan, Lloyd B. Jeffs, Lorne R. Palmer, Cory Giesbrecht
Filed: 25 May 21
Utility
Compositions and methods for delivering messenger RNA
7 Dec 21
The present invention provides compositions comprising nucleic acid molecules, such as mRNA molecules, encapsulated within lipid particles.
Michael J. Abrams, James Heyes, Adam Judge, Kieu Mong Lam, Lorne Ralph Palmer, Stephen P. Reid, Edward D. Yaworski
Filed: 30 Jun 17
Utility
Lipid formulations for nucleic acid delivery
12 Oct 21
The present invention provides novel, stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles.
Edward Yaworski, Kieu Lam, Lloyd Jeffs, Lorne Palmer, Ian MacLachlan
Filed: 12 Apr 21
Utility
Substituted 2,3-dihydro-1H-indene analogs and methods using same
28 Sep 21
The present invention includes substituted 2,3-dihydro-1H-indene analogs, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient.
Yingzhi Bi, Bruce D. Dorsey, Christopher Brooks Moore
Filed: 24 Apr 18
Utility
Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same
24 Aug 21
The present invention includes novel substituted bicyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient.
Andrew G. Cole, Bruce D. Dorsey, Ramesh Kakarla, Steven Kultgen, Jorge Quintero
Filed: 20 Mar 18
Utility
Lipids and compositions for the delivery of therapeutics
3 Aug 21
Muthiah Manoharan, Muthusamy Jayaraman, Kallanthottathil G. Rajeev, Laxman Eltepu, Steven Ansell, Jianxin Chen
Filed: 8 Jun 17
Utility
Substituted pyridinone-containing trycyclic compounds, and methods using same
25 May 21
The present invention includes substituted pyridinone-containing tricyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection in a patient.
Laurèn Danielle Bailey, Yingzhi Bi, Shuai Chen, Bruce D. Dorsey, Dimitar B. Gotchev, Richard James Holland, Ramesh Kakarla, Duyan Nguyen, Mark Christopher Wood
Filed: 30 Mar 20
Utility
Substituted chromane-8-carboxamide compounds and analogues thereof, and methods using same
11 May 21
The present invention includes novel substituted bicyclic (such as 4-substituted-chromane-8-carboxamide compounds), and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient.
Andrew G. Cole, Steven Kultgen
Filed: 13 Sep 17
Utility
Lipid compositions
23 Mar 21
Muthiah Manoharan, Kallanthottathil G. Rajeev, Muthusamy Jayaraman, David Butler, Michael E. Jung
Filed: 4 Oct 19