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CSTL Castle Biosciences

APP
Utility
Methods of Diagnosing and Treating Patients with Cutaneous Squamous Cell Carcinoma
5 Aug 21
The present disclosure relates to methods for predicting the risk of recurrence and/or metastasis, or both in primary cutaneous squamous cell carcinoma (cSCC).
Robert Willis COOK, Kyle R. COVINGTON, Derek MAETZOLD, Sarah J. KURLEY
Filed: 31 Jan 20
APP
Utility
Methods of Diagnosing and Treating Patients with Cutaneous Squamous Cell Carcinoma
5 Aug 21
The present disclosure relates to methods for predicting the risk of recurrence and/or metastasis, or both in primary cutaneous squamous cell carcinoma (cSCC).
Robert Willis COOK, Kyle R. COVINGTON, Derek MAETZOLD, Sarah J KURLEY
Filed: 14 Aug 20
APP
Utility
Diagnostic Test for Predicting Metastasis and Recurrence In Cutaneous Melanoma
18 Nov 20
The invention as disclosed herein in encompasses a method for predicting the risk of metastasis of a primary cutaneous melanoma tumor, the method encompassing measuring the gene-expression levels of at least eight genes selected from a specific gene set in a sample taken from the primary cutaneous melanoma tumor; determining a gene-expression profile signature from the gene expression levels of the at least eight genes; comparing the gene-expression profile to the gene-expression profile of a predictive training set; and providing an indication as to whether the primary cutaneous melanoma tumor is a certain class of metastasis or treatment risk when the gene expression profile indicates that expression levels of at least eight genes are altered in a predictive manner as compared to the gene expression profile of the predictive training set.
Robert Willis COOK, Derek MAETZOLD, Kristen OESCHLAGER
Filed: 16 Jan 20
APP
Utility
Methods for Predicting Risk of Recurrence And/or Metastasis In Soft Tissue Sarcoma
21 Oct 20
The disclosure related to the development of a gene expression profile to predict soft tissue sarcoma (STS) recurrence, distant metastasis, or both.
Robert Willis COOK, Weiwei SHAN, Derek MAETZOLD
Filed: 4 Jun 17
GRANT
Utility
Diagnostic test for predicting metastasis and recurrence in cutaneous melanoma
2 Mar 20
The invention as disclosed herein in encompasses a method for predicting the risk of metastasis of a primary cutaneous melanoma tumor, the method encompassing measuring the gene-expression levels of at least eight genes selected from a specific gene set in a sample taken from the primary cutaneous melanoma tumor; determining a gene-expression profile signature from the gene expression levels of the at least eight genes; comparing the gene-expression profile to the gene-expression profile of a predictive training set; and providing an indication as to whether the primary cutaneous melanoma tumor is a certain class of metastasis or treatment risk when the gene expression profile indicates that expression levels of at least eight genes are altered in a predictive manner as compared to the gene expression profile of the predictive training set.
Robert Willis Cook, Derek Maetzold, Kristen Oeschlager
Filed: 18 Mar 16
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