9 patents
Utility
Tolerogenic synthetic nanocarriers for allergy therapy
10 Oct 23
Disclosed are synthetic nanocarrier compositions, and related methods, comprising immunosuppressants and MHC Class II-restricted epitopes of an allergen that provide tolerogenic immune responses specific to the allergen.
Takashi Kei Kishimoto, Christopher Fraser, Roberto A. Maldonado
Filed: 4 Mar 16
Utility
Tolerogenic synthetic nanocarriers
8 Aug 23
This invention relates, at least in part, to compositions comprising synthetic nanocarriers and immunosuppressants that result in immune suppressive effects.
Christopher Fraser, Grayson B. Lipford, Christopher J. Roy, Roberto A. Maldonado
Filed: 22 Feb 16
Utility
Methods and compositions for attenuating anti-viral transfer vector immune responses
25 Apr 23
Provided herein are methods and related compositions for administering viral transfer vectors and antigen-presenting cell targeted immunosuppressants.
Takashi Kei Kishimoto
Filed: 7 Sep 15
Utility
Methods and compositions related to combined treatment with antiinflammatories and synthetic nanocarriers comprising an immunosuppressant
30 Aug 22
Provided herein are methods and compositions, such as kits, related to compositions comprising synthetic nanocarriers comprising an immunosuppressant and compositions comprising an uricase and a composition comprising an anti-inflammatory therapeutic.
Lloyd Johnston
Filed: 11 Mar 18
Utility
Methods for providing polymeric synthetic nanocarriers for generating antigen-specific tolerance immune responses
1 Feb 22
Disclosed are synthetic nanocarrier compositions that provide controlled release of immunosuppressants as well as related methods.
David H. Altreuter, Aaron P. Griset, Roberto A. Maldonado
Filed: 6 Aug 18
Utility
Methods for administering synthetic nanocarriers that generate humoral and cytotoxic T lymphocyte responses
2 Mar 21
Disclosed are methods for generating humoral and cytotoxic T lymphocyte (CTL) immune responses in a subject and related compositions.
David H. Altreuter, Conlin O'Neil, Petr Ilyinskii
Filed: 27 Jul 12
Utility
Tolerogenic synthetic nanocarriers to reduce or prevent anaphylaxis in response to a non-allergenic antigen
1 Jun 20
This invention relates to methods for reducing or preventing anaphylaxis to non-allergenic antigens with compositions comprising immunosuppressants, and related compositions.
Roberto A. Maldonado
Filed: 1 May 14
Utility
Tolerogenic synthetic nanocarriers for generating CD8+ regulatory T cells
14 Oct 19
Disclosed are synthetic nanocarrier methods, and related compositions, comprising administering MHC Class I-restricted and/or MHC Class II-restricted epitopes of an antigen and immunosuppressants in order to generate tolerogenic immune responses against the antigen, such as the generation of antigen-specific CD8+ regulatory T cells.
Takashi Kei Kishimoto, Christopher Fraser, Roberto A. Maldonado
Filed: 26 Jul 15
Utility
Methods related to administering immunosuppressants and therapeutic macromolecules at a reduced pharmacodynamically effective dose
7 Oct 19
Disclosed are compositions and methods that provide pharmacodynamic effects specific to therapeutic macromolecules.
Roberto A. Maldonado, Takashi Kei Kishimoto
Filed: 1 May 14
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