20 patents
Utility
Chimeric Antigen Receptor with Modified Hinge Region and Uses Thereof
30 Nov 23
The present disclosure provides a chimeric antigen receptor (CAR) molecule comprising a modified hinge domain, wherein the hinge domain comprises the amino acid sequence of SEQ ID NO:1.
BUO CHEN, Xiangqun LI, Ang Zhang
Filed: 27 Oct 22
Utility
Cell separation apparatus
21 Nov 23
Systems and methods herein are directed towards the separation of biologic material to obtain a target cell volume and/or cell concentration for harvesting.
Rolf Wolters, Anthony Yang, Josh Nelson, Stuart K. Williams
Filed: 18 Sep 17
Utility
Cell Separation Apparatus and Methods of Use
19 Oct 23
The present invention provides automated devices for use in supporting various cell therapies and tissue engineering methods.
Gregory D. ARIFF, Thomas CANNON, Jennifer L. CASE, Christian L. HALLER, Paul KOSNIK, Charles P. LUDDY, Craig A. MAUCH, Erik VOSSMAN, Stuart K. WILLIAMS
Filed: 18 Jan 23
Utility
Ribonucleases for Treating Viral Infections
11 May 23
This disclosure is directed to compounds and pharmaceutical compositions for treating and preventing viral diseases, as Covid-19.
JAMIE SULLEY, LUIS SQUIQUERA, THOMAS HODGE, SABINA GLOZMAN, Vered CAPLAN
Filed: 19 Mar 21
Utility
Methods of transdifferentiation and methods of use thereof
4 Apr 23
Disclosed herein is a method for manufacturing a population of human insulin producing cells from non-pancreatic β-cells, wherein the resulting insulin producing cells have increased insulin content, or increased glucose regulated secretion of insulin, or a combination of both.
Sarah Ferber
Filed: 1 Apr 20
Utility
Cell-culture Bioreactor
16 Mar 23
A cell-culture bioreactor operative to provide real-time reactor management in the fields of stir control, sparge control, and heat management responsively to wireless sensor feedback to optimize operating conditions to maximize cell-culture yield; and a bioreactor comprising: a vessel, having an open top; a headplate, configured to seal the vessel's open top; and a stirring device, comprising at least two independent stirring elements; wherein each of the stirring elements is configured to independently stir media accommodated within the vessel.
VERED CAPLAN, MICHAEL FAINSHTEIN
Filed: 18 Feb 21
Utility
Process and System for Acellular Therapy
9 Mar 23
Process and system for acellular therapy in a human subject are provided.
Sabina GLOZMAN
Filed: 28 Jan 21
Utility
Mobile Processing Unit and Laboratories
8 Sep 22
A mobile processing laboratory (MPL) is provided, configured for facilitating performing therewithin a cell therapy process.
Gilad Ish Shalom, Inbar Barzilay, Vered Caplan
Filed: 8 Mar 22
Utility
Prophylactic Protection Against Viral Infections
1 Sep 22
The present disclosure provides methods for prophylactically treating a subject for viral infections comprising topically administering a ranpirnase composition.
Luis Squiquera, Thomas Hodge, Jamie Sulley
Filed: 16 May 22
Utility
Prophylactic protection against viral infections
17 May 22
The present disclosure provides methods for prophylactically treating a subject for viral infections comprising topically administering a ranpirnase composition.
Luis Squiquera, Thomas Hodge, Jamie Sulley
Filed: 26 Jul 17
Utility
Three Dimensional Clusters of Transdifferentiated Cells, Compositions and Methods Thereof
10 Jun 21
The present disclosure provides compositions and methods for providing a cell replacement therapy to treat various diseases, including pancreatic diseases and diabetes.
Efrat ASSA KUNIK, Smadar COHEN, Alon MONSONEGO, Sarah FERBER
Filed: 6 Mar 19
Utility
Prophylactic Protection Against Viral Infections, Particularly Hiv
20 May 21
An experiment has shown that ranpirnase is a microbicide.
Jamie SULLEY, Luis SQUlQUERA, David SIDRANSKY, Tom HODGE
Filed: 6 Oct 20
Utility
Transdifferentiated cell populations and methods of use thereof
13 Apr 21
Disclosed herein are methods for manufacturing transdifferentiated populations of non-pancreatic human insulin producing cells, and methods for enriching populations of non-pancreatic β-cells for cells comprising an enriched capacity for transcription factor-induced transdifferentiation into a pancreatic β-cell phenotype and function.
Sarah Ferber
Filed: 7 Nov 19
Utility
Cell populations, methods of transdifferentiation and methods of use thereof
16 Mar 21
The present invention provides methods for the sequential and temporally-regulated administration of pancreatic transcription factors to induce non-pancreatic cells to transdifferentiate and mature along the pancreatic β-cell lineage.
Sarah Ferber
Filed: 25 Apr 18
Utility
Bioxomes Particles, Redoxomes, Method and Composition
25 Feb 21
Provided an artificial bioxome particle comprising a cell membrane component and designed to undergo fusion with a target cell, wherein said bioxome particle is engineered to carry a cargo comprising at least one predetermined active molecule; and wherein said cargo can be released into the target cell after the fusion of the bioxome particle with the target cell; and wherein the cell membrane component is derived from a selected cellular or extracellular source; methods of use of the particles; and processes for manufacturing thereof.
Sabina GLOZMAN
Filed: 4 Apr 19
Utility
Prophylactic protection against viral infections, particularly HIV
16 Nov 20
An experiment has shown that ranpirnase is a microbicide.
Jamie Sulley, Luis Squiquera, David Sidransky, Tom Hodge
Filed: 27 Apr 17
Utility
Methods of Transdifferentiation and Methods of Use Thereof
23 Sep 20
Disclosed herein is a method for manufacturing a population of human insulin producing cells from non-pancreatic β-cells, wherein the resulting insulin producing cells have increased insulin content, or increased glucose regulated secretion of insulin, or a combination of both.
Sarah FERBER
Filed: 31 Mar 20
Utility
Methods of transdifferentiation and methods of use thereof
1 Jun 20
Disclosed herein is a method for manufacturing a population of human insulin producing cells from non-pancreatic β-cells, wherein the resulting insulin producing cells have increased insulin content, or increased glucose regulated secretion of insulin, or a combination of both.
Sarah Ferber
Filed: 28 Nov 18
Utility
Transdifferentiated Cell Populations and Methods of Use Thereof
6 May 20
Disclosed herein are methods for manufacturing transdifferentiated populations of non-pancreatic human insulin producing cells, and methods for enriching populations of non-pancreatic β-cells for cells comprising an enriched capacity for transcription factor-induced transdifferentiation into a pancreatic β-cell phenotype and function.
Sarah FERBER
Filed: 6 Nov 19
Utility
Compositions and Methods for Providing Cell Replacement Therapy
8 Apr 20
Disclosed is a three-dimensional (3D) cell cluster comprising transdifferentiated adult mammalian non-pancreatic beta cells having a mature pancreatic beta cell phenotype and function and a scaffold, wherein said transdifferentiated cells have an enhanced mature pancreatic beta cell phenotype compared to a 3D cell cluster without a scaffold and to similarly transdifferentiated cells cultured as a two-dimensional (2D) monolayer.
Sarah FERBER
Filed: 26 May 18
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