47 patents
Page 3 of 3
Utility
Compositions of matter for treatment of ophthalmic conditions by selectively removing senescent cells from the eye
18 Nov 19
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent.
Remi-Martin Laberge, Judith Campisi, Marco Demaria, Nathaniel David, Alain Philippe Vasserot, James L. Kirkland, Tamar Tchkonia, Yi Zhu, Darren J. Baker, Bennett G. Childs, Jan M. A. van Deursen
Filed: 17 Apr 18
Utility
Unit dose of an aryl sulfonamide that is effective for treating eye disease and averting potential vision loss
18 Nov 19
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent.
Remi-Martin Laberge, Judith Campisi, Marco Demaria, Nathaniel David, Darren J. Baker, James L. Kirkland, Tamar Tchkonia, Yi Zhu, Jan M. A. van Deursen, Alain Philippe Vasserot, Bennett G. Childs
Filed: 12 Jun 18
Utility
Therapy for Removing Senescent Cells and Treating Senescence-associated Disease Using an MDM2 Inhibitor
13 Nov 19
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent.
Remi-Martin Laberge, Judith Campisi, Albert Davalos, Marco Demaria, Nathaniel David, Alain Philippe Vasserot, James L. Kirkland, Tamar Tchkonia, Jennifer Elisseeff, Chaekyu Kim, Okhee Jeon, Yi Zhu
Filed: 9 Jul 19
Utility
Phosphonamidates that are Bcl Family Antagonists for Use in Clinical Management of Conditions Caused or Mediated By Senescent Cells and for Treating Cancer
30 Oct 19
This disclosure provides compounds with Bcl inhibitory activity based on a new chemical scaffold.
Anne-Marie Beausoleil, Ryan Hudson
Filed: 28 May 19
Utility
Phospholidines that are Bcl Family Antagonists for Use in Clinical Management of Conditions Caused or Mediated By Senescent Cells and for Treating Cancer
30 Oct 19
This disclosure provides compounds with Bcl inhibitory activity based on a new chemical scaffold.
Anne-Marie Beausoleil, Ryan Hudson
Filed: 28 May 19
Utility
Composition Comprising a Gene Vector That Selectively Depletes P16 Positive Senescent Cells
16 Oct 19
Polypeptides, viruses, methods and compositions provided herein are useful for the selective elimination of senescent cells.
Serge Lichtsteiner, Nathaniel David
Filed: 9 Jun 19
Utility
Chemical entities that kill senescent cells for use in treating age-related disease
30 Sep 19
Disclosed herein are compounds that are effective for treatment of various disease states associated with senescence.
Nathaniel David
Filed: 7 Mar 18