21 patents
Utility
Intratumoral Vaccination
28 Sep 23
The present disclosure relates to, inter alia, a method for treating a tumor by intratumorally delivering an effective amount of a composition comprising an expression vector that comprises a first nucleotide sequence encoding a secretable vaccine protein, and a second nucleotide sequence encoding a T cell costimulatory fusion protein.
Suresh DE SILVA, Taylor SCHREIBER
Filed: 6 Dec 22
Utility
Compositions and methods for adjoining type I and type II extracellular domains as heterologous chimeric proteins
23 May 23
The present invention relates to, inter alia, compositions and methods, including chimeric proteins that find use in the treatment of disease, such as immunotherapies for cancer and autoimmunity.
Taylor Schreiber, George Fromm, Suresh De Silva, Neal Schilling
Filed: 8 Apr 20
Utility
Production of Cell-based Vaccines
25 Nov 21
The present disclosure provides a method for cell preservation, for example, cryopreservation of cells exposed to ionizing radiation.
Damien HALLET, Taylor SCHREIBER
Filed: 3 Dec 18
Utility
Combination Cell-based Therapies
11 Nov 21
The present disclosure provides methods of treatment with cells having a vaccine (e.g., gp96-Ig) and cells having a T-cell co-stimulatory molecule.
Jeff HUTCHINS
Filed: 1 Oct 19
Utility
Immune-mediated Coronavirus Treatments
16 Sep 21
The present invention provides an expression vector, host cells, methods and kits for the treatment or prevention of a coronavirus infection in a subject.
Jeff T. HUTCHINS, Natasa STRBO, Jeffrey WOLF
Filed: 2 Mar 21
Utility
GP96-BASED Cancer Therapy
10 Jun 21
The present disclosure relates, inter alia, to compositions and methods for treating cancer, including lung cancer (e.g., Non-Small Cell Lung Cancer), comprising administering (a) a cell harboring an expression vector comprising a nucleotide sequence that encodes a secretable vaccine protein and (b) an immune checkpoint inhibitor to a subject in need thereof.
Jeff HUTCHINS, Lori MCDERMOTT
Filed: 27 Nov 18
Utility
Vector Co-expressing Vaccine and Costimulatory Molecules
6 Jan 21
Compositions and methods for co-expressing a secretable vaccine protein (such as gp96-Ig) and T-cell co-stimulatory molecules from a single vector, among others, are provided herein.
Taylor SCHREIBER, George FROMM
Filed: 23 Jul 20
Utility
Vector co-expressing vaccine and costimulatory molecules
21 Sep 20
Compositions and methods for co-expressing a secretable vaccine protein (such as gp96-Ig) and T-cell co-stimulatory molecules from a single vector, among others, are provided herein.
Taylor Schreiber, George Fromm
Filed: 24 Jun 18
Utility
Vector co-expressing vaccine and costimulatory molecules
31 Aug 20
Compositions and methods for co-expressing a secretable vaccine protein (such as gp96-Ig) and T-cell co-stimulatory molecules from a single vector, among others, are provided herein.
Taylor Schreiber, George Fromm
Filed: 24 Jun 18
Utility
Compositions and Methods for Adjoining Type I and Type II Extracellular Domains As Heterologous Chimeric Proteins
19 Aug 20
The present invention relates to, inter alia, compositions and methods, including chimeric proteins that find use in the treatment of disease, such as immunotherapies for cancer and autoimmunity.
Taylor SCHREIBER, George FROMM, Suresh DE SILVA, Neal Schilling
Filed: 7 Apr 20
Utility
Compositions and Methods for Adjoining Type I and Type II Extracellular Domains As Heterologous Chimeric Proteins
5 Aug 20
The present invention relates to, inter alia, compositions and methods, including chimeric proteins that find use in the treatment of disease, such as immunotherapies for cancer and autoimmunity.
Taylor SCHREIBER, George FROMM, Suresh DE SILVA, Neal Schilling
Filed: 8 Mar 20
Utility
Compositions and methods for adjoining type I and type II extracellular domains as heterologous chimeric proteins
25 May 20
The present invention relates to, inter alia, compositions and methods, including chimeric proteins that find use in the treatment of disease, such as immunotherapies for cancer and autoimmunity.
Taylor Schreiber, George Fromm, Suresh De Silva, Neal Schilling
Filed: 28 Jun 18
Utility
Compositions and methods for adjoining type I and type II extracellular domains as heterologous chimeric proteins
18 May 20
The present invention relates to, inter alia, compositions and methods, including chimeric proteins that find use in the treatment of disease, such as immunotherapies for cancer and autoimmunity.
Taylor Schreiber, George Fromm, Suresh De Silva, Neal Schilling
Filed: 7 Nov 19
Utility
Compositions and methods for adjoining type I and type II extracellular domains as heterologous chimeric proteins
11 May 20
The present invention relates to, inter alia, compositions and methods, including chimeric proteins that find use in the treatment of disease, such as immunotherapies for cancer and autoimmunity.
Taylor Schreiber, George Fromm, Suresh De Silva
Filed: 28 Jun 18
Utility
Compositions and Methods for Adjoining Type I and Type II Extracellular Domains As Heterologous Chimeric Proteins
1 Apr 20
The present invention relates to, inter alia, compositions and methods, including chimeric proteins that find use in the treatment of disease, such as immunotherapies for cancer and autoimmunity.
Taylor SCHREIBER, George FROMM, Suresh DE SILVA, Neal SCHILLING
Filed: 7 Nov 19
Utility
Intratumoral Vaccination
29 Jan 20
The present disclosure relates to, inter alia, a method for treating a tumor by intratumorally delivering an effective amount of a composition comprising an expression vector that comprises a first nucleotide sequence encoding a secretable vaccine protein, and a second nucleotide sequence encoding a T cell costimulatory fusion protein.
Suresh DE SILVA, Taylor SCHREIBER
Filed: 2 Apr 18
Utility
Compositions and methods for adjoining type I and type II extracellular domains as heterologous chimeric proteins
27 Jan 20
The present invention relates to, inter alia, compositions and methods, including chimeric proteins that find use in the treatment of disease, such as immunotherapies for cancer and autoimmunity.
Taylor Schreiber, George Fromm, Suresh De Silva
Filed: 27 Nov 18
Utility
Compositions and methods for adjoining type I and type II extracellular domains as heterologous chimeric proteins
6 Jan 20
The present invention relates to, inter alia, compositions and methods, including chimeric proteins that find use in the treatment of disease, such as immunotherapies for cancer and autoimmunity.
Taylor Schreiber, George Fromm, Suresh De Silva
Filed: 28 Jun 18
Utility
Compositions and methods for adjoining type I and type II extracellular domains as heterologous chimeric proteins
2 Dec 19
The present invention relates to, inter alia, compositions and methods, including chimeric proteins that find use in the treatment of disease, such as immunotherapies for cancer and autoimmunity.
Taylor Schreiber, George Fromm, Suresh De Silva
Filed: 28 Jun 18
Utility
Indirect acoustic drying system and method
25 Nov 19
Disclosed is an acoustic head for indirectly drying a material, the acoustic head including at least one ultrasonic transducer facing the material, the material having a first side, and a second side, the second side opposite the first side, the second side defining a surface to be dried, the ultrasonic transducer positioned facing the first side; and an air delivery unit positioned facing the first side of the material.
Zinovy Zalman Plavnik, Glenn Johnson Emory, Aliaksandr Hrynchuk, Jason Lye, Richard Terrell Sisk, Leonid Anatolyevich Volozhanin
Filed: 30 Jun 14