9 patents
Utility
ANTI-SARS-COV-2 Antigen Antibodies and Related Compositions and Methods
30 Nov 23
Provided are antibodies that specifically bind a Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) antigen.
Erik Yusko, Peter J. R. Ebert, Amy Gilbert, Gladys Keitany, Mark Klinger, Ben Rubin
Filed: 29 Oct 21
Utility
Determining WT-1-Specific T Cells and WT-1 Specific T Cell Receptors (TCRS)
9 Feb 23
The invention is directed to methods for determining antigen-specific T cells generally and to T cell receptors which bind an epitope of the Wilms' tumor antigen-1 (WT1) protein specifically.
Marcos E. Milla, Mark Klinger, Peter J.R. Ebert, Timothy L. Hayes, Edward J. Osborne, Joyce K. Hu
Filed: 14 Jul 22
Utility
Immunocompetence Assessment by Adaptive Immune Receptor Diversity and Clonality Characterization
22 Sep 22
Disclosed are methods for determining the immunological status of the adaptive immune system of a subject by identifying and quantifying rearranged DNA (and/or subsequently transcribed RNA) sequences encoding T cell receptor (TCR) and/or immunoglobulin (IG) polypeptides, in a lymphoid DNA-containing sample from the subject.
Harlan S. Robins, Julie Rubinstein, Ryan O. Emerson, Jianda Yuan
Filed: 18 Nov 21
Utility
Determining Antigen-Specific T-Cells
11 Aug 22
The invention is directed to methods for determining antigen-specific T cells.
Mark Klinger, Malek Faham
Filed: 20 Jan 22
Utility
Monitoring Health and Disease Status Using Clonotype Profiles
28 Apr 22
There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer, especially lymphoid neoplasms, such as lymphomas and leukemias.
Malek Faham, Thomas Willis
Filed: 10 May 21
Utility
Methods for Diagnosing Infectious Disease and Determining Hla Status Using Immune Repertoire Sequencing
9 Dec 21
Methods are provided for predicting a subject's infection status using high-throughput T cell receptor sequencing to match the subject's TCR repertoire to a known set of disease-associated T cell receptor sequences.
Ryan O. Emerson, Harlan S. Robins, Mark J. Rieder, William S. Dewitt, III, Christopher S. Carlson
Filed: 9 Jun 21
Utility
Methods of Monitoring Conditions by Sequence Analysis
7 Oct 21
There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer.
Malek Faham, Thomas Willis
Filed: 16 Apr 21
Utility
Synthetic Strands For Nucleic Acid Sequencing And Related Methods And Systems
6 May 21
Provided are synthetic strands for nucleic acid sequencing.
Harlan S. Robins
Filed: 5 Nov 20
Utility
Methods Using Randomer-Containing Synthetic Molecules
14 Oct 20
Methods are provided for correction of amplification bias and quantitation of adaptive immune cells in a sample using synthetic templates that include random oligonucleotide sequences.
Anna M. SHERWOOD, Ryan O. EMERSON, Harlan S. ROBINS, Mark J. RIEDER, Joe PARSONS
Filed: 30 Apr 20
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