20 patents
Utility
Method for studying V(D)J combinatory diversity
3 Oct 23
The invention relates to a method for analyzing the diversity of the catalogue of T and/or B lymphocytes in an individual, based on the amplification, from a sample, of genomic DNA fragments by PCR multi-n-plexes, with n≥2, carried out with a combination of at least 3 primers defining at least 2 primer couples, each of which includes a primer specifically hybridizing upstream and/or in a given V or D gene and a primer specifically hybridizing downstream and/or in a given J gene, in order to obtain the amplification of at least two fragments characteristic of two distinct V-J or D-J rearrangements from each primer couple.
Nicolas Pasqual, Sebastien Weisbuch
Filed: 6 Nov 17
Utility
Synthetic strands for nucleic acid sequencing and related methods and systems
25 Jul 23
Provided are synthetic strands for nucleic acid sequencing.
Harlan S. Robins
Filed: 5 Nov 20
Utility
Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
19 Jul 22
The invention is directed to methods for determining antigen-specific T cells generally and to T cell receptors which bind an epitope of the Wilms' tumor antigen-1 (WT1) protein specifically.
Marcos E. Milla, Mark Klinger, Peter J. R. Ebert, Timothy Lee Hayes, Edward J. Osborne, Joyce K. Hu
Filed: 13 Jun 18
Utility
Determining antigen-specific T-cells
1 Mar 22
The invention is directed to methods for determining antigen-specific T cells.
Mark Klinger, Malek Faham
Filed: 21 Aug 18
Utility
Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements
22 Feb 22
Methods and compositions are provided for quantifying the number of biological input molecules of one or more target genes of interest in a PCR.
Ryan O. Emerson, Anna M. Sherwood, Harlan S. Robins
Filed: 21 Nov 18
Utility
Methods using randomer-containing synthetic molecules
15 Feb 22
Methods are provided for correction of amplification bias and quantitation of adaptive immune cells in a sample using synthetic templates that include random oligonucleotide sequences.
Anna M. Sherwood, Ryan O. Emerson, Harlan S. Robins, Mark J. Rieder, Joe Parsons
Filed: 1 May 20
Utility
Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization
23 Nov 21
Disclosed are methods for determining the immunological status of the adaptive immune system of a subject by identifying and quantifying rearranged DNA (and/or subsequently transcribed RNA) sequences encoding T cell receptor (TCR) and/or immunoglobulin (IG) polypeptides, in a lymphoid DNA-containing sample from the subject.
Harlan S. Robins, Julie Rubinstein, Ryan Emerson, Jianda Yuan
Filed: 11 May 18
Utility
Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing
20 Jul 21
Methods of monitoring and measuring dynamic adaptive immune cell responses are provided.
Harlan S. Robins, William Sumner DeWitt, III, Ryan O. Emerson
Filed: 24 Nov 15
Utility
Methods for diagnosing infectious disease and determining HLA status using immune repertoire sequencing
29 Jun 21
Methods are provided for predicting a subject's infection status using high-throughput T cell receptor sequencing to match the subject's TCR repertoire to a known set of disease-associated T cell receptor sequences.
Ryan O. Emerson, Harlan S. Robins, Mark Rieder, William Dewitt, III, Christopher Carlson
Filed: 24 Feb 16
Utility
Method of identifying human compatible T cell receptors specific for an antigenic target
22 Jun 21
Methods are provided for identifying T cell receptors that specifically bind a particular antigenic target and can be used as therapeutics against disease.
Harlan S. Robins, Aude Georgiana Chapuis, Thomas M. Schmitt, Philip Greenberg, Anna Sherwood
Filed: 1 Apr 16
Utility
High affinity T cell receptors and uses thereof
8 Jun 21
The present disclosure provides TCRs with high or enhanced affinity against various tumor associated antigens (including human Wilms tumor protein 1 (WT 1) epitopes and mesothelin epitopes), T cells expressing such high affinity antigen specific TCRs, nucleic acids encoding the same, and compositions for use in treating diseases or disorders in which cells overexpress one or more of these antigens, such as in cancer.
Thomas M. Schmitt, Philip D. Greenberg, Aude G. Chapuis, Harlan S. Robins, Anna M. Sherwood
Filed: 23 Dec 16
Utility
Monitoring health and disease status using clonotype profiles
1 Jun 21
There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer, especially lymphoid neoplasms, such as lymphomas and leukemias.
Malek Faham, Thomas Willis
Filed: 13 Dec 18
Utility
Methods of monitoring conditions by sequence analysis
11 May 21
There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer.
Malek Faham, Thomas Willis
Filed: 17 Dec 18
Utility
Compositions and methods for measuring and calibrating amplification bias in multiplexed PCR reactions
19 Jan 21
Compositions and methods are described for standardizing the DNA amplification efficiencies of a highly heterogeneous set of oligonucleotide primers as may typically be used to amplify a heterogeneous set of DNA templates that contains rearranged lymphoid cell DNA encoding T cell receptors (TCR) or immunoglobulins (IG).
Harlan Saul Robins, Christopher Scott Carlson, Robert J. Livingston, Ryan O. Emerson, Anna M. Sherwood
Filed: 8 Jan 19
Utility
Monitoring health and disease status using clonotype profiles
14 Dec 20
There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer, especially lymphoid neoplasms, such as lymphomas and leukemias.
Malek Faham, Thomas Willis
Filed: 4 Sep 18
Utility
Monitoring health and disease status using clonotype profiles
31 Aug 20
There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer, especially lymphoid neoplasms, such as lymphomas and leukemias.
Malek Faham, Thomas Willis
Filed: 29 Nov 17
Utility
Method for genotyping clonotype profiles using sequence tags
6 Jan 20
The invention is directed to sequence-based profiling of populations of nucleic acids by multiplex amplification and attachment of one or more sequence tags to target nucleic acids and/or copies thereof followed by high-throughput sequencing of the amplification product.
Thomas Asbury, Kieran Hervold, Chitra Kotwaliwale, Malek Faham, Martin Moorhead, Li Weng, Tobias Wittkop, Jianbiao Zheng
Filed: 1 Aug 18
Utility
Monitoring health and disease status using clonotype profiles
30 Dec 19
There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer, especially lymphoid neoplasms, such as lymphomas and leukemias.
Malek Faham, Thomas Willis
Filed: 8 Jun 17
Utility
Determining antigen-specific T-cells
7 Oct 19
The invention is directed to methods for determining antigen-specific T cells.
Mark Klinger, Malek Faham
Filed: 29 Nov 17
Utility
Identification of antigen-specific B cell receptors
30 Sep 19
Compositions and methods are disclosed for identifying B-cell receptor sequences that bind to corresponding antigens.
Mark Klinger
Filed: 19 Sep 17
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