20 patents
Utility
PHD Inhibitor Compounds, Compositions, and Methods of Use
21 Sep 23
Thomas P. BLAISDELL, Senkara Rao ALLU, Paul E. FLEMING
Filed: 13 Aug 21
Utility
Manufacturing Process for 3,5-DICHLOROPICOLINONITRILE for Synthesis of Vadadustat
14 Sep 23
Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the synthesis of vadadustat.
Valdas JURKAUSKAS, Young Chun JUNG, Taesoo KWON, Arunachalam KANNAN, Vijaya Bhasker GONDI
Filed: 1 Jul 21
Utility
Therapeutic Methods Using Vadadustat
14 Sep 23
This invention provides methods for the treatment of anemia in patients with chronic kidney disease (CKD) using vadadustat (Compound 1), including methods suitable for conversion, correction, and maintenance therapy for patients.
Emil deGoma, Nobuko Maruyama, Genki Kaneko
Filed: 29 Oct 20
Utility
PHD Inhibitor Compounds, Compositions, and Use
20 Jul 23
Paul E. FLEMING, Thomas P. BLAISDELL, Senkara Rao ALLU
Filed: 19 Mar 21
Utility
Treatment of Viral Infections, of Organ Injury, and of Related Conditions Using a Hif Prolyl Hydroxylase Inhibitor or a Hif-alpha Stabilizer
13 Jul 23
Disclosed herein are new therapeutic methods comprising administering compounds that can stabilize HIF and inhibit HIF prolyl hydroxylase (HIF-PH).
Steven BURKE, Michael RABINOWITZ
Filed: 20 Apr 21
Utility
PHD Inhibitor Compounds, Compositions, and Their Use
6 Jul 23
Paul E. FLEMING, Thomas P. BLAISDELL, Senkara Rao ALLU
Filed: 19 Mar 21
Utility
Prolyl Hydroxylase Inhibitors and Methods of Use
29 Jun 23
The present disclosure relates to HIF-1α prolyl hydroxylase inhibitors, compositions which comprise the HIF-1α prolyl hydroxylase inhibitors described herein and to methods for controlling, inter alia, Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, and anemia.
Richard Masaru Kawamoto, Shengde Wu, Artem G. Evdokimov, Kenneth D. Greis, Angelique Sun Boyer, Namal C. Warshakoon
Filed: 27 Jul 22
Utility
PHD Inhibitor Compounds, Compositions, and Use
25 May 23
Paul E. FLEMING, Thomas P. BLAISDELL, Senkara Rao ALLU
Filed: 19 Mar 21
Utility
Method for Producing Nitrogen-containing Heteroarylcarboxamide Acetic Acid Derivative
25 May 23
Kazufumi OOTSUKI, Muneki KISHIDA, Atsushi MORODA, Kohki FUKUHARA, Hirotoshi YAGISHITA
Filed: 9 Dec 20
Utility
Methods for Treating Viral Infections, Organ Injury, and Related Conditions
11 May 23
Disclosed herein are new therapeutic methods comprising administering compounds that can stabilize HIF and inhibit HIF prolyl hydroxylase (HIF-PH).
Steven Burke, Michael Rabinowitz
Filed: 26 Oct 22
Utility
Compositions and Methods for Treating Anemia
9 Mar 23
Provided herein are specific doses of, and dosing regimens for, using a HIF prolyl hydroxylase inhibitor in treating or preventing anemia, such as anemia secondary to or associated with chronic kidney disease, anemia secondary to or associated with non-dialysis dependent chronic kidney disease anemia associated with or resulting from chemotherapy, or anemia associated with AIDS.
Alexander Smith, Gurudatt Ajay Chandorkar, Ene Ikpong Ette, Bradley John Maroni, Charlotte Suzanne Hartman, Ramin Farzaneh-Far, Jula Kern Inrig
Filed: 4 Apr 22
Utility
Process for Preparing [(3-HYDROXYPYRIDINE-2-CARBONYL)AMINO]ALKANOIC Acids, Esters and Amides
5 Jan 23
Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter alia, 5-aryl substituted and 5-heteroaryl substituted [(3-hydroxypyridine-2-carbonyl]amino}acetic acids.
Christopher M. Lanthier, Boris Gorin, Jan Oudenes, Craig Edward Dixon, Alan Quigbo Lu, James Densmore Copp, John Michael Janusz
Filed: 31 Jan 22
Utility
Solid Forms of {[5-(3-CHLOROPHENYL)-3-HYDROXYPYRIDINE-2-CARBONYL]AMINO}ACETIC Acid, Compositions, and Uses Thereof
10 Feb 22
Provided herein are solid forms comprising {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid, compositions comprising the solid forms, methods of making the solid forms and methods of their use for the treatment of various diseases and/or disorders.
James Densmore Copp, Ann W. Newman, Anne Luong
Filed: 15 Jun 21
Utility
Benzimidazole Derivative for Use In the Treatment of Inflammatory Disorders
2 Dec 21
Michael Rabinowitz, Hariharan Venkatesan, Mark D. Rosen
Filed: 2 Oct 19
Utility
Solid Forms of {[5-(3-CHLOROPHENYL)-3-HYDROXYPYRIDINE-2-CARBONYL]AMINO}ACETIC Acid
8 Jul 21
Sudhir Ranjan, Xiaoyang Wang
Filed: 12 Nov 20
Utility
Prolyl Hydroxylase Inhibitors and Methods of Use
13 May 21
The present disclosure relates to HIF-1α prolyl hydroxylase inhibitors, compositions which comprise the HIF-1α prolyl hydroxylase inhibitors described herein and to methods for controlling, inter alia, Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, and anemia.
Richard Masaru Kawamoto, Shengde Wu, Artem G. Evdokimov, Kenneth D. Greis, Angelique Sun Boyer, Namal C. Warshakoon
Filed: 22 Jun 20
Utility
Process for Preparing [(3-HYDROXYPYRIDINE-2-CARBONYL)AMINO]ALKANOIC Acids, Esters and Amides
29 Apr 21
Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter alia, 5-aryl substituted and 5-heteroaryl substituted [(3-hydroxypyridine-2-carbonyl]amino}acetic acids.
Christopher M. Lanthier, Boris Gorin, Jan Oudenes, Craig Edward Dixon, Alan Quigbo Lu, James Densmore Copp, John Michael Janusz
Filed: 6 Jul 20
Utility
Process for Preparing 2-[[5-(3-Chlorophenyl)-3-Hydroxypyridine-2-Carbonyl]Amino]Acetic Acid
11 Mar 21
Boris I. Gorin, Christopher M. Lanthier, Anne Buu Chau Luong, James Densmore Copp, Javier Gonzalez
Filed: 8 May 19
Utility
Solid Forms of {[5-(3-CHLOROPHENYL)-3-HYDROXYPYRIDINE-2-CARBONYL]AMINO}ACETIC Acid, Compositions, and Uses Thereof
4 Nov 20
Provided herein are solid forms comprising {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions comprising the solid forms, methods of making the solid forms and methods of their use for the treatment of various diseases and/or disorders.
James Densmore Copp, Ann W. Newman, Anne Luong
Filed: 9 Feb 20
Utility
Process for Preparing [(3-HYDROXYPYRIDINE-2-CARBONYL)AMINO]ALKANOIC Acids, Esters and Amides
11 Dec 19
Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter cilia, 5-aryl substituted and 5-heteroaryl substituted [(3-hydroxypyridine-2-carbonyl]amino}acetic acids.
Christopher M. Lanthier, Boris Gorin, Jan Oudenes, Craig Edward Dixon, Alan Quigbo Lu, James Densmore Copp, John Michael Janusz
Filed: 12 Mar 19
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