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PHIO Phio Pharmaceuticals

APP
Utility
Immunotherapy of Cancer
11 Nov 21
Immunogenic modulators and compositions comprising oligonucleotide agents capable of inhibiting suppression of immune response by reducing expression of one or more gene involved with an immune response suppression mechanism.
Alexey Wolfson, Alexey Eliseev, Taisia Shmushkovich
Filed: 15 Jan 21
APP
Utility
Methods for Treating Aging and Skin Disorders Using Nucleic Acids Targeting Tyr or MMP1
11 Nov 21
The present invention relates to RNAi constructs with improved tissue and cellular uptake characteristics and methods of use of these compounds in dermal applications.
Gerard Cauwenbergh
Filed: 15 Jan 21
GRANT
Utility
Reduced size self-delivering RNAI compounds
14 Sep 21
The present invention relates to methods for in vivo administration of sd-rxRNA molecules.
Anastasia Khvorova, William Salomon, Joanne Kamens, Dmitry Samarsky, Tod M. Woolf, James Cardia
Filed: 7 Feb 19
APP
Utility
Rna Interference In Dermal and Fibrotic Indications
26 Aug 21
The present invention relates to RNAi constructs with improved tissue and cellular uptake characteristics and methods of use of these compounds in dermal and fibrotic applications.
Anastasia Khvorova, William Salomon, Joanne Kamens, Dmitry Samarsky, Tod M. Woolf, Pamela A. Pavco, Lyn Libertine, James Cardia, Karen G. Bulock
Filed: 15 Jan 21
GRANT
Utility
Reduced size self-delivering nucleic acid compounds targeting long non-coding RNA
1 Jun 21
The present disclosure relates to RNAi constructs with improved cellular uptake characteristics and methods of use of these compounds for silencing expression of long coding RNAs (IncRNAs).
James Cardia, Karen G. Bulock, Joke Hedwig Vandesompele, Gert Van Peer
Filed: 19 Oct 16
APP
Utility
Reduced Size Self-delivering Rnai Compounds
20 May 21
The present invention relates to RNAi constructs with minimal double-stranded regions, and their use in gene silencing.
Anastasia Khvorova, William Salomon, Joanne Kamens, Dmitry Samarsky, Tod M. Woolf, James Cardia
Filed: 21 Jul 20
GRANT
Utility
Nucleic acid molecules targeting superoxide dismutase 1 (SOD1)
11 May 21
Aspects of the invention relate to methods for treating ALS comprising administering to a subject in need thereof a therapeutically effective amount of a nucleic acid molecule that is directed against a gene encoding superoxide dismutase 1 (SOD1).
James Cardia, Michael Byrne, Karen G. Bulock, Pamela A. Pavco, Lyn Libertine
Filed: 6 Jul 16
APP
Utility
Rna Interference In Ocular Indications
4 Mar 21
The present invention relates to ocular administration of sd-rxRNA and rxRNAori molecules.
Lyn Libertine, Anastasia Khvorova, William Salomon, Joanne Kamens, Dmitry Samarsky, Tod M. Woolf, James Cardia, Pamela A. Pavco
Filed: 12 May 20
GRANT
Utility
Immunotherapy of cancer
2 Mar 21
Immunogenic modulators and compositions comprising oligonucleotide agents capable of inhibiting suppression of immune response by reducing expression of one or more gene involved with an immune suppression mechanism.
Alexey Wolfson, Alexey Eliseev, Taisia Shmushkovich
Filed: 2 Dec 14
GRANT
Utility
RNA interference in dermal and fibrotic indications
9 Feb 21
The present invention relates to RNAi constructs with improved tissue and cellular uptake characteristics and methods of use of these compounds in dermal and fibrotic applications.
Anastasia Khvorova, William Salomon, Joanne Kamens, Dmitry Samarsky, Tod M. Woolf, Pamela A. Pavco, Lyn Libertine, James Cardia, Karen G. Bulock
Filed: 12 Mar 18
GRANT
Utility
Methods for treating aging and skin disorders using nucleic acids targeting Tyr or MMP1
26 Jan 21
The present invention relates to RNAi constructs with improved tissue and cellular uptake characteristics and methods of use of these compounds in dermal applications.
Gerard Cauwenbergh
Filed: 4 Sep 15
GRANT
Utility
Reduced size self-delivering RNAI compounds
28 Dec 20
The present invention relates to RNAi constructs with minimal double-stranded regions, and their use in gene silencing.
Anastasia Khvorova, William Salomon, Joanne Kamens, Dmitry Samarsky, Tod M. Woolf, James Cardia
Filed: 27 Jun 18
GRANT
Utility
RNA interference in skin indications
26 Oct 20
The present invention relates to RNAi constructs with improved tissue and cellular uptake characteristics and methods of use of these compounds in dermal applications.
Anastasia Khvorova, William Salomon, Joanne Kamens, Dmitry Samarsky, Tod M. Woolf, Pamela A. Pavco, James Cardia
Filed: 25 Feb 18
GRANT
Utility
Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach
19 Oct 20
In one aspect, the disclosure provides methods for treating a neurodegenerative disorder, comprising administering to a subject in need thereof a therapeutically effective amount of a nucleic acid molecule and a therapeutically effective amount of a small molecule that activates NF-κB p65 and increases expression of manganese superoxide dismutase (MnSOD/SOD2) and/or expression of a related protein or enzyme.
Michael Byrne, Antonella Favit-VanPelt
Filed: 5 Jul 16
APP
Utility
Rna Duplexes with Single Stranded Phosphorothioate Nucleotide Regions for Additional Functionality
30 Sep 20
The present invention relates to RNAi constructs and their use in gene silencing.
TOD M. WOOLF, JOANNE KAMENS, WILLIAM SALOMON, ANASTASIA KHVOROVA
Filed: 10 Nov 19
GRANT
Utility
Reduced size self-delivering RNAI compounds
14 Sep 20
The present invention relates to RNAi constructs with minimal double-stranded regions, and their use in gene silencing.
Anastasia Khvorova, William Salomon, Joanne Kamens, Dmitry Samarsky, Tod M. Woolf, James Cardia
Filed: 24 Sep 15
APP
Utility
Chemically Modified Oligonucleotides
8 Jul 20
The disclosure relates, in some aspects, to methods and compositions for production of immunogenic compositions.
Alexey Eliseev
Filed: 6 Aug 18
GRANT
Utility
RNA interference in ocular indications
25 May 20
The present invention relates to ocular administration of sd-rxRNA and rxRNAori molecules.
Lyn Libertine, Anastasia Khvorova, William Salomon, Joanne Kamens, Dmitry Samarsky, Tod M. Woolf, James Cardia, Pamela A. Pavco
Filed: 29 Nov 18
GRANT
Utility
Modified RNAi polynucleotides and uses thereof
27 Apr 20
The invention related to improved RNAi constructs and uses thereof.
Pamela A. Pavco, Joanne Kamens, Tod M. Woolf, William Salomon, Anastasia Khvorova
Filed: 4 Oct 18
APP
Utility
Effective Sensitizing Dose of a Gelled Immunomodulating Topical Composition
1 Apr 20
The present invention relates to compositions and methods of treating warts and other human papilloma virus (HPV) skin infections.
William R. Levis, Leonard L. Kaplan, John G. Callahan
Filed: 7 Apr 19
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