29 patents
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Utility
Rna Duplexes with Single Stranded Phosphorothioate Nucleotide Regions for Additional Functionality
30 Sep 20
The present invention relates to RNAi constructs and their use in gene silencing.
TOD M. WOOLF, JOANNE KAMENS, WILLIAM SALOMON, ANASTASIA KHVOROVA
Filed: 10 Nov 19
Utility
Reduced size self-delivering RNAI compounds
14 Sep 20
The present invention relates to RNAi constructs with minimal double-stranded regions, and their use in gene silencing.
Anastasia Khvorova, William Salomon, Joanne Kamens, Dmitry Samarsky, Tod M. Woolf, James Cardia
Filed: 24 Sep 15
Utility
Chemically Modified Oligonucleotides
8 Jul 20
The disclosure relates, in some aspects, to methods and compositions for production of immunogenic compositions.
Alexey Eliseev
Filed: 6 Aug 18
Utility
RNA interference in ocular indications
25 May 20
The present invention relates to ocular administration of sd-rxRNA and rxRNAori molecules.
Lyn Libertine, Anastasia Khvorova, William Salomon, Joanne Kamens, Dmitry Samarsky, Tod M. Woolf, James Cardia, Pamela A. Pavco
Filed: 29 Nov 18
Utility
Modified RNAi polynucleotides and uses thereof
27 Apr 20
The invention related to improved RNAi constructs and uses thereof.
Pamela A. Pavco, Joanne Kamens, Tod M. Woolf, William Salomon, Anastasia Khvorova
Filed: 4 Oct 18
Utility
Effective Sensitizing Dose of a Gelled Immunomodulating Topical Composition
1 Apr 20
The present invention relates to compositions and methods of treating warts and other human papilloma virus (HPV) skin infections.
William R. Levis, Leonard L. Kaplan, John G. Callahan
Filed: 7 Apr 19
Utility
Topical Delivery of Nucleic Acid Compounds
18 Mar 20
In some aspects, the disclosure relates to RNAi constructs with improved tissue and cellular uptake characteristics and methods of use of these compounds in dermal applications.
Melissa Maxwell, Richard J. Looby
Filed: 18 Apr 18
Utility
Reduced Size Self-delivering Rnai Compounds
1 Jan 20
The present invention relates to methods for in vivo administration of sd-rxRNA molecules.
Anastasia Khvorova, William Salomon, Joanne Kamens, Dmitry Samarsky, Tod M. Woolf, James Cardia
Filed: 6 Feb 19
Utility
RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
18 Nov 19
The present invention relates to RNAi constructs and their use in gene silencing.
Tod M. Woolf, Joanne Kamens, William Salomon, Anastasia Khvorova
Filed: 29 Jun 17