11 patents
Utility
Methods and Treatment Involving Excess Free Light
4 Jan 24
The present disclosure relates to methods of detecting free (active) LIGHT in biological samples to diagnose conditions associated with elevated free LIGHT, as well as to predict the effectiveness of anti-LIGHT therapies.
Garry A. Neil, Inbal Zafir-Lavie
Filed: 5 Jun 23
Utility
Methods and Treatment for Complex Lymphatic Malformations
30 Nov 23
The present disclosure relates to methods of treating subjects with complex lymphatic malformations, comprising administering to a human subject diagnosed with a complex lymphatic malformation an effective amount of trans-4-[4-Amino-5-(7-methoxyl-1H-indol-2-yl)-imidazo[5,1-f][1,2,4]triazine-7-yl]-cyclohexanecarboxylic acid, or a pharmaceutically acceptable salt thereof at certain dosages.
Garry A. Neil
Filed: 25 May 23
Utility
Methods and Treatment for Adult-Onset Still's Disease and Systemic-Onset Juvenile Idiopathic Arthritis Involving Antibodies to IL-18
7 Sep 23
The present disclosure relates to methods of treating adult-onset Still’s disease (AOSD) or systemic-onset juvenile idiopathic arthritis (SoJIA), optionally associated with elevated IL-18 levels, comprising administering to a human subject diagnosed with AOSD or SoJIA an effective amount of an anti-IL-18 antibody at certain dosages.
Garry A. Neil, H. Jeffrey Wilkins
Filed: 19 Dec 22
Utility
Compounds, Compositions and Methods
17 Aug 23
Reza Mazhari, Djelila Mezaache, Blake M Paterson, James Vornov, Rachel M. Garner, Todd Nelson
Filed: 23 Sep 22
Utility
Method of treating acute respiratory distress syndrome (ARDS) or acute lung injury (ALI) associate with COVID-19 by administering an anti-LIGHT antibody
25 Jul 23
The present disclosure relates to methods of detecting free (active) LIGHT in biological samples to diagnose conditions associated with elevated free LIGHT, as well as to predict the effectiveness of anti-LIGHT therapies.
Garry A. Neil, Inbal Zafir-Lavie
Filed: 31 Mar 21
Utility
Methods and Treatment Involving Antibodies to IL-18
29 Jun 23
The present disclosure relates to methods of treating and/or detecting respiratory and inflammatory conditions associated with IL-18 by administering an anti-IL-18 antibody, optionally wherein the antibody comprises the six CDRs of SEQ ID NOS: 122, 123, 124, 126, 127, and 128, wherein 122-124 comprise the heavy chain CDRs and 126-128 comprise the light chain CDRs, to subjects aving elevated IL-18 levels.
Garry A. Neil, Inbal Zafir-Lavie, Lori Roadcap
Filed: 31 May 21
Utility
Nucleic acid prodrugs
25 Oct 22
The invention relates to a method of treating a mitochondrial DNA depletion syndrome, comprising administering to a patient a therapeutically-effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof.
Stephen B. Thomas, Patrick J. Crutcher
Filed: 19 Jun 20
Utility
Nucleotide Prodrugs
13 May 21
The invention relates to nucleotide prodrugs and pharmaceutical preparations thereof.
Stephen B. Thomas, Patrick J. Crutcher, Fabrizio Pertusati, Elisa Pileggi
Filed: 7 Jan 19
Utility
Nucleic Acid Prodrugs
8 Apr 21
The invention relates to nucleotide prodrugs and pharmaceutical preparations thereof.
Stephen B. Thomas, Patrick J. Crutcher
Filed: 19 Jun 20
Utility
Nucleic acid prodrugs
17 Aug 20
Stephen B. Thomas, Patrick J. Crutcher
Filed: 15 Nov 16
Utility
Compounds, compositions and methods
13 Jul 20
Reza Mazhari, Djelila Mezaache, Blake M. Paterson, James Vornov, Rachel M. Garner, Todd Nelson
Filed: 10 Feb 19
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