3 patents
Utility
Compounds and methods for treating tight junction permeabtility
21 Mar 23
The present invention provides Larazotide derivative compositions that resist protease degradation, and in various embodiments, do not demonstrate an inverse dose response, and/or can be delivered at higher doses without loss of potency or efficacy, thereby allowing improved therapy and more desirable dosing schedules.
Jay P. Madan, Balasingham Radhakrishnan, Sandeep Laumas, Christopher Prior
Filed: 25 Feb 19
Utility
Treatment of cancer with larazotide derivatives in combination with immune checkpoint inhibitors
22 Mar 22
The present invention provides compositions and methods for treating a patient having cancer, as well as methods for potentiating an immune checkpoint inhibitor therapy.
Jay Madan, Sandeep Laumas
Filed: 23 Apr 21
Utility
Compositions and methods for treating disease associated with permeability of intestinal epithelium
13 Jul 21
The present invention provides methods for treating disorders associated with intestinal barrier dysfunction and increased intestinal permeability.
Jay P. Madan, Anthony Blikslager, Sandeep Laumas
Filed: 12 Feb 18
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