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PRTA Prothena

APP
Utility
Determination of Parkinson's Disease
20 Jan 22
Methods and compositions for accurate identification of Parkinson's disease are disclosed.
Christian Czech, Sebastian Dziadek, Lidija Pestic-Dragovich, Lei Tang, Thomas Kremer, Wagner Marcelo Zago, Tsu-Shuen Tsao, Adriana Racolta, Marta Canamero, Ronald Torres, Mirko Ritter
Filed: 8 Aug 19
GRANT
Utility
Monitoring immunotherapy of Lewy body disease from constipation symptoms
7 Dec 21
The invention provides methods of monitoring immunotherapy directed against alpha-synuclein by comparing a subject's constipation symptoms before treatment and at one or more times during and/or after treatment.
Gene G. Kinney, Theresa Anne Neumann, Daniel Keith Ness
Filed: 19 Nov 14
APP
Utility
Anti-transthyretin Antibodies
2 Dec 21
The invention provides antibodies that specifically bind transthyretin (TTR).
YUE LIU, TARLOCHAN S. NIJJAR, AVIJIT CHAKRABARTTY, JEFFREY N. HIGAKI
Filed: 4 May 21
APP
Utility
Antibodies Recognizing Tau
26 Aug 21
The invention provides antibodies that specifically bind tau.
Tarlochan S. Nijjar, Robin BARBOUR, Philip James DOLAN, III, Yue LIU, Svetlana ALEXANDER, Mark E. RENZ
Filed: 22 Feb 21
APP
Utility
Anti-transthyretin Antibodies
24 Jun 21
The invention provides antibodies that specifically bind to transthyretin (TTR).
Tarlochan S. Nijjar, Avijit Chakrabartty, Jeffrey N. Higaki
Filed: 18 Dec 20
GRANT
Utility
Anti-transthyretin antibodies
8 Jun 21
The invention provides antibodies that specifically bind transthyretin (TTR).
Yue Liu, Tarlochan S. Nijjar, Avijit Chakrabartty, Jeffrey N. Higaki
Filed: 26 Sep 19
APP
Utility
Methods For Detecting Phosphorylated Alpha-Synuclein
3 Jun 21
The invention provides methods of detecting alpha-synuclein using a capture antibody and a reporter antibody.
Robin Barbour, Lynn R. Zieske, Sarah Hamren
Filed: 30 Oct 20
APP
Utility
Antibodies Recognizing Tau
6 May 21
The invention provides antibodies that specifically bind tau.
Robin Barbour, Philip James Dolan, III, Yue Liu, Svetlana Alexander, Mark E. Renz
Filed: 4 Nov 20
GRANT
Utility
Antibodies recognizing tau
30 Mar 21
The invention provides antibodies that specifically bind tau.
Tarlochan S. Nijjar, Robin Barbour, Philip James Dolan, III, Yue Liu, Svetlana Alexander, Mark E. Renz
Filed: 3 Mar 20
APP
Utility
Antibody Formulations and Methods
18 Mar 21
Antibody formulations and methods useful for prophylaxis or treatment of amyloidosis, including AA amyloidosis and AL amyloidosis.
Patrick GARIDEL, Isaac Craig HENDERSON, Pamela KLEIN
Filed: 23 Jun 20
APP
Utility
Compositions for Treating Amyloidosis
18 Mar 21
Antibody formulations and methods useful for treatment of peripheral neuropathy in patients with AL amyloidosis.
Gene G. KINNEY, Spencer D. GUTHRIE, Martin KOLLER
Filed: 25 Sep 20
APP
Utility
Dosing Regimes for Treatment of Synucleinopathies
18 Mar 21
The invention provides dosage regimes for treatment of synucleinopathies.
Jay Soto, Daniel Keith Ness, Martin Koller, Diane Mould, Frank Boess, Meret Martin-Facklam, Valerie Cosson, Hans Peter Grimm, Ronald Gieschke, Sara Belli, Silke Weber
Filed: 23 Jul 20
APP
Utility
Humanized Antibodies That Recognize Alpha-Synuclein
11 Feb 21
The present application discloses humanized 9E4 antibodies.
Jose William Saldanha, Tarlochan S. Nijjar
Filed: 16 Jun 20
APP
Utility
Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease
4 Feb 21
The invention provides improved agents and methods for treatment of diseases associated with synucleinopathic diseases, including Lewy bodies of alpha-synuclein in the brain of a patient.
Dale B. Schenk, Eliezer Masliah, Manuel J. Buttini, Tamie J. Chilcote, Edward M. Rockenstein, Kate Dora Games
Filed: 7 Apr 20
APP
Utility
Tau Immunotherapy
4 Feb 21
The invention provides antibodies to tau.
Peter SEUBERT, Philip James DOLAN, III, Yue LIU, Robin BARBOUR
Filed: 20 Jul 20
GRANT
Utility
Antibodies recognizing tau
2 Feb 21
The invention provides antibodies that specifically bind tau.
Robin Barbour, Philip James Dolan, III, Yue Liu
Filed: 2 May 17
GRANT
Utility
Anti-transthyretin antibodies
2 Feb 21
The invention provides antibodies that specifically bind to transthyretin (TTR).
Tarlochan S. Nijjar, Avijit Chakrabartty, Jeffrey N. Higaki
Filed: 30 Oct 19
APP
Utility
Treatment and Prophylaxis of Amyloidosis
21 Jan 21
Methods for the treatment of AL amyloidosis associated with the deposition of misfolded immunoglobulin light chain proteins and corresponding uses related to an antibody, such as a 2A4 antibody, or a pharmaceutical formulation comprising the antibody.
Tarlochan S. NIJJAR, Philip J. DOLAN, Robin BARBOUR
Filed: 22 Mar 19
GRANT
Utility
Anti-Laminin4 antibodies specific for LG4-5
12 Jan 21
The invention provides antibodies that specifically bind to the LG4-5 modules of the G domain of laminin α4.
Stephen Jed Tam, Yue Liu, Robin Barbour, Theodore Yednock, Kenneth Flanagan
Filed: 12 Mar 18
GRANT
Utility
Antibodies recognizing tau
12 Jan 21
The invention provides antibodies that specifically bind tau.
Robin Barbour, Philip James Dolan, III, Yue Liu, Svetlana Alexander, Mark E. Renz
Filed: 2 May 17
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