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GH Guardant Health

APP
Utility
Systems and Methods to Detect Rare Mutations and Copy Number Variation
2 Dec 21
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli TALASAZ, Stefanie Ann Ward MORTIMER
Filed: 6 Aug 21
APP
Utility
Methods and Systems for Determining Fusion Events
2 Dec 21
Methods, systems, and apparatuses for determining fusion events are described.
Sante Gnerre
Filed: 12 Feb 21
APP
Utility
Microsatellite Instability Detection In Cell-free Dna
25 Nov 21
Provided herein are methods for determining the microsatellite instability status of samples.
Aliaksandr ARTSIOMENKA, Marcin SIKORA, Catalin BARBACIORU, Darya CHUDOVA, Martina I. LEFTEROVA
Filed: 30 Aug 19
APP
Utility
Systems and Methods to Detect Rare Mutations and Copy Number Variation
18 Nov 21
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli TALASAZ
Filed: 27 Jul 21
APP
Utility
Systems and Methods for Detecting Insertions and Deletions
18 Nov 21
Systems and methods are provided for improving accuracy of detecting an insertion or deletion (indel) from a plurality of sequence reads derived from cell-free deoxyribonucleic acid (cfDNA).
Marcin SIKORA
Filed: 22 Jul 21
APP
Utility
Systems and Methods to Detect Rare Mutations and Copy Number Variation
4 Nov 21
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli Talasaz
Filed: 8 Jul 21
APP
Utility
Methods for Classifying Genetic Mutations Detected In Cell-free Nucleic Acids As Tumor or Non-tumor Origin
4 Nov 21
Provided herein are methods of differentiating tumor and non-tumor origin nucleic acid variants in cell-free nucleic acid (cfNA) samples.
Jennifer YEN, Andrey CHURSOV
Filed: 11 Mar 21
GRANT
Utility
Methods and systems for detecting genetic variants
19 Oct 21
Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample.
AmirAli Talasaz, Helmy Eltoukhy, Stefanie Ann Ward Mortimer
Filed: 31 Jul 20
GRANT
Utility
Methods and systems for detecting genetic variants
19 Oct 21
Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample.
AmirAli Talasaz, Helmy Eltoukhy, Stefanie Ann Ward Mortimer
Filed: 4 Feb 21
GRANT
Utility
Methods and systems for detecting genetic variants
14 Sep 21
Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample.
AmirAli Talasaz, Stefanie Ann Ward Mortimer, Helmy Eltoukhy
Filed: 7 Jan 20
GRANT
Utility
Methods and systems for adjusting tumor mutational burden by tumor fraction and coverage
14 Sep 21
Provided herein are methods for detecting tumor mutational burden (TMB) in subjects.
Katie Julia Quinn, Elena Helman, Darya Chudova
Filed: 30 Jun 20
APP
Utility
Machine Learning for Somatic Single Nucleotide Variant Detection in Cell-free Tumor Nucleic acid Sequencing Applications
26 Aug 21
Systems and methods are disclosed to detect single-nucleotide variations (SNVs) from somatic sources in a cell-free biological sample of a subject by generating training data with class labels; in computer memory, generating a machine learning unit comprising one output for each of adenine (A), cytosine (C), guanine (G), and thymine (T) calls; training the machine learning unit; and applying the machine learning unit to detect the SNVs from somatic sources in the cell-free biological sample of the subject, wherein the cell-free biological sample comprises a mixture of nucleic acid molecules from somatic and germline sources.
Bahram Ghaffarzadeh Kermani, Helmy Eltoukhy
Filed: 17 Feb 21
GRANT
Utility
Systems and methods to detect rare mutations and copy number variation
17 Aug 21
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli Talasaz, Stefanie Ann Ward Mortimer
Filed: 13 Oct 20
GRANT
Utility
Systems and methods to detect rare mutations and copy number variation
17 Aug 21
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli Talasaz, Stefanie Ann Ward Mortimer
Filed: 14 Oct 20
GRANT
Utility
Gene mutations and copy number alterations of EGFR, KRAS and MET
10 Aug 21
Sequence variants and copy number variations in the EGFR, KRAS and MET genes are biomarkers for resistance to anti-EGFR therapies for cancer.
Scott Kopetz, AmirAli Talasaz
Filed: 4 Mar 19
APP
Utility
Methods, Compositions and Systems for Improving the Binding of Methylated Polynucleotides
15 Jul 21
In an aspect, a method for detecting the presence or absence of tumor in a polynucleotide sample obtained from a subject comprising: (i) adding carrier nucleic acid molecules to the polynucleotide sample to generate a first sample; wherein the set of carrier nucleic acid molecules comprises at least one subset of unmethylated carrier nucleic acid molecules and/or at least one subset of methylated carrier nucleic acid molecules and at least one end of the carrier nucleic acid molecules is modified to prevent ligation; (ii) partitioning the first sample into at least two partitioned sets using capturing agent that binds selectively to methylated polynucleotides; (iii) processing the partitioned sample to generate processed sample, wherein the processing comprises: tagging, amplifying and enriching; (iv) sequencing the processed sample to generate a set of sequencing reads; and (v) analyzing a plurality of sequencing reads to detect the presence or absence of tumor.
Dustin Howard HITE, Farsheed GHADIRI, Stefanie Ann Ward MORTIMER
Filed: 25 Nov 20
APP
Utility
Methods and Systems for Improving Patient Monitoring after Surgery
15 Jul 21
In an aspect, a method for detecting the presence or absence of cancer in a subject comprises: (a) obtaining samples from the subject from different time points, wherein a first sample obtained at first time point is a polynucleotide sample from a tumor tissue specimen and a second sample obtained at second time point is a cell-free polynucleotide sample from a blood sample; (b) processing polynucleotides from each of the samples, comprising: i) tagging at least a portion of the polynucleotides, thereby generating tagged parent polynucleotides; ii) amplifying at least a portion of the tagged parent polynucleotides to generate progeny polynucleotides; iii) enriching at least a portion of the progeny polynucleotides for target genomic regions; thereby generating enriched polynucleotides; and iv) sequencing at least a portion of the enriched polynucleotides to generate sequencing reads; and (c) analyzing genomic regions for at least one epigenetic feature from the sequencing reads.
Ariel JAIMOVICH, Yupeng HE, Oscar WESTESSON, William J. GREENLEAF
Filed: 20 Jan 21
GRANT
Utility
Methods for multi-resolution analysis of cell-free nucleic acids
13 Jul 21
The present disclosure provides a method for enriching for multiple genomic regions using a first bait set that selectively hybridizes to a first set of genomic regions of a nucleic acid sample and a second bait set that selectively hybridizes to a second set of genomic regions of the nucleic acid sample.
Darya Chudova, Helmy Eltoukhy, Stefanie Ann Ward Mortimer, Diana Abdueva
Filed: 18 Dec 19
APP
Utility
Methods and Systems for Detecting Genetic Variants
3 Jun 21
Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample.
AmirAli TALASAZ, Helmy ELTOUKHY, Stefanie Ann Ward MORTIMER
Filed: 4 Feb 21
GRANT
Utility
Correcting for deamination-induced sequence errors
18 May 21
Sequencing nucleic acids can identify variations associated with presence, susceptibility or prognosis of disease.
Marcin Sikora, Andrew Kennedy, Ariel Jaimovich, Darya Chudova, Stephen Fairclough
Filed: 4 May 20
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