67 patents
Utility
Methods for early detection of cancer
28 Nov 23
Disclosed herein are methods, compositions, and devices for use in the early detection of cancer.
Stefanie Ann Ward Mortimer, AmirAli Talasaz, Darya Chudova, Helmy Eltoukhy
Filed: 19 Jan 23
Utility
Methods for multi-resolution analysis of cell-free nucleic acids
14 Nov 23
The present disclosure provides a method for enriching for multiple genomic regions using a first bait set that selectively hybridizes to a first set of genomic regions of a nucleic acid sample and a second bait set that selectively hybridizes to a second set of genomic regions of the nucleic acid sample.
Darya Chudova, Helmy Eltoukhy, Stefanie Ann Ward Mortimer, Diana Abdueva
Filed: 14 Nov 22
Utility
Methods for multi-resolution analysis of cell-free nucleic acids
14 Nov 23
The present disclosure provides a method for enriching for multiple genomic regions using a first bait set that selectively hybridizes to a first set of genomic regions of a nucleic acid sample and a second bait set that selectively hybridizes to a second set of genomic regions of the nucleic acid sample.
Darya Chudova, Helmy Eltoukhy, Stefanie Ann Ward Mortimer, Diana Abdueva
Filed: 17 Jan 23
Utility
Methods for early detection of cancer
17 Oct 23
Disclosed herein are methods, compositions, and devices for use in the early detection of cancer.
Stefanie Ann Ward Mortimer, AmirAli Talasaz, Darya Chudova, Helmy Eltoukhy
Filed: 19 Oct 22
Utility
Microsatellite instability detection in cell-free DNA
3 Oct 23
Provided herein are methods for determining the microsatellite instability status of samples.
Aliaksandr Artsiomenka, Marcin Sikora, Catalin Barbacioru, Darya Chudova, Martina I. Lefterova
Filed: 19 Jun 20
Utility
Systems and methods to detect rare mutations and copy number variation
3 Oct 23
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli Talasaz
Filed: 20 Jan 23
Utility
Methods and systems for detecting genetic variants
26 Sep 23
Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample.
Amirali Talasaz, Helmy Eltoukhy
Filed: 27 Oct 21
Utility
Methods and systems for detecting genetic variants
26 Sep 23
Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample.
AmirAli Talasaz, Helmy Eltoukhy, Stefanie Ann Ward Mortimer
Filed: 27 Oct 21
Utility
Population based treatment recommender using cell free DNA
12 Sep 23
Systems and methods are disclosed for generating a therapeutic response predict or detecting a disease, by: using a genetic analyzer to generate genetic information; receiving into computer memory a training dataset comprising, for each of a plurality of individuals having a disease, (1) genetic information from the individual generated at first time point and (2) treatment response of the individual to one or more therapeutic interventions determined at a second, later, time point; and implementing a machine learning algorithm using the dataset to generate at least one computer implemented classification algorithm, wherein the classification algorithm, based on genetic information from a subject, predicts therapeutic response of the subject to a therapeutic intervention.
Helmy Eltoukhy, AmirAli Talasaz
Filed: 7 Oct 16
Utility
Correcting for deamination-induced sequence errors
8 Aug 23
Sequencing nucleic acids can identify variations associated with presence, susceptibility or prognosis of disease.
Marcin Sikora, Andrew Kennedy, Ariel Jaimovich, Darya Chudova, Stephen Fairclough
Filed: 23 Mar 21
Utility
Methods and systems for detecting genetic variants
16 May 23
Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample.
AmirAli Talasaz, Helmy Eltoukhy, Stefanie Ann Ward Mortimer
Filed: 28 Dec 21
Utility
Compositions and methods for isolating cell-free DNA
9 May 23
Disclosed herein are compositions and methods for isolating DNA, such as cell-free DNA (cfDNA).
Andrew Kennedy, Ariel Jaimovich, Matthew Schultz, William J. Greenleaf
Filed: 31 Jan 20
Utility
Methods for early detection of cancer
9 May 23
Disclosed herein are methods for use in detection of single nucleotide variants (SNVs) or indels.
Stefanie Ann Ward Mortimer, AmirAli Talasaz, Darya Chudova, Helmy Eltoukhy
Filed: 7 Mar 22
Utility
Methods and systems for detecting genetic variants
2 May 23
Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample.
AmirAli Talasaz, Helmy Eltoukhy, Stefanie Ann Ward Mortimer
Filed: 28 Jun 22
Utility
Methods and systems for detecting genetic variants
2 May 23
Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample.
AmirAli Talasaz, Helmy Eltoukhy, Stefanie Ann Ward Mortimer
Filed: 30 Jun 22
Utility
Cancer evolution detection and diagnostic
4 Apr 23
The present disclosure provides methods for determining a probability that after any of a number of therapeutic interventions, an initial state of a subject, such as somatic cell mutational status of a subject with cancer, will develop a subsequent state.
Helmy Eltoukhy, AmirAli Talasaz
Filed: 25 Jul 22
Utility
Methods and systems for detecting genetic variants
21 Mar 23
Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample.
AmirAli Talasaz, Helmy Eltoukhy, Stefanie Ann Ward Mortimer
Filed: 28 Jun 22
Utility
Systems and methods to detect rare mutations and copy number variation
14 Feb 23
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli Talasaz
Filed: 16 Mar 22
Utility
Machine learning for somatic single nucleotide variant detection in cell-free tumor nucleic acid sequencing applications
13 Dec 22
Systems and methods are disclosed to detect single-nucleotide variations (SNVs) from somatic sources in a cell-free biological sample of a subject by generating training data with class labels; in computer memory, generating a machine learning unit comprising one output for each of adenine (A), cytosine (C), guanine (G), and thymine (T) calls; training the machine learning unit; and applying the machine learning unit to detect the SNVs from somatic sources in the cell-free biological sample of the subject, wherein the cell-free biological sample comprises a mixture of nucleic acid molecules from somatic and germline sources.
Bahram Ghaffarzadeh Kermani, Helmy Eltoukhy
Filed: 17 Feb 21
Utility
Methods and systems for analyzing nucleic acid molecules
6 Dec 22
The disclosure provides methods for processing nucleic acid populations containing different forms (e.g., RNA and DNA, single-stranded or double-stranded) and/or extents of modification (e.g., cytosine methylation, association with proteins).
Andrew Kennedy, Stefanie Ann Ward Mortimer, Helmy Eltoukhy, AmirAli Talasaz
Filed: 24 Jun 19