18 patents
Utility
Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents
2 May 23
This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.
Jean-Christophe Andrez, Kristen Nicole Burford, Christoph Martin Dehnhardt, Thilo Focken, Michael Edward Grimwood, Qi Jia, Verner Alexander Lofstrand, Shaoyi Sun, Steven Sigmund Wesolowski, Michael Scott Wilson, Alla Yurevna Zenova
Filed: 24 Feb 21
Utility
Benzenesulfonamide compounds and their use as therapeutic agents
10 May 22
This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.
Kristen Nicole Burford, Thilo Focken, Verner Alexander Lofstrand, Michael Scott Wilson, Alla Yurevna Zenova
Filed: 13 Jul 20
Utility
Substituted benzamides and methods of use thereof
21 Dec 21
Sultan Chowdhury, Christoph Martin Dehnhardt, Thilo Focken, Michael Edward Grimwood, Ivan William Hemeon, Steven McKerrall, Daniel Sutherlin
Filed: 3 Sep 20
Utility
Benzenesulfonamide compouds and their use as therapeutic agents
16 Nov 21
This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.
Jean-Christophe Andrez, David Earl Bogucki, Kristen Nicole Burford, Sultan Chowdhury, Charles Jay Cohen, Shannon Marie Decker, Christoph Martin Dehnhardt, Robert Joseph Devita, James Roy Empfield, Thilo Focken, Michael Edward Grimwood, Syed Abid Hasan, Qi Jia, James Philip Johnson, Jr., Michael Scott Wilson, Alla Yurevna Zenova
Filed: 2 Mar 20
Utility
Therapeutic compounds and methods of use thereof
19 Oct 21
Jean-Christophe Andrez, Philippe Bergeron, Paul Robert Bichler, Sultan Chowdhury, Christoph Martin Dehnhardt, Thilo Focken, Wei Gong, Michael Edward Grimwood, Abid Hasan, Ivan William Hemeon, Qi Jia, Brian Salvatore Safina, Shaoyi Sun, Michael Scott Wilson, Alla Yurevna Zenova
Filed: 3 Dec 19
Utility
Methods for enhancing the bio availability and exposure of a voltage-gated potassium channel opener
5 Oct 21
In certain embodiments, the present disclosure is directed to methods and uses for treating seizure disorders in a human, wherein the methods and uses comprise orally administering a therapeutically effective amount of the voltage-gated potassium channel allosteric modulator, N-[4-(6-fluoro-3,4-dihydro-1H-isoquinolin-2-yl)-2,6-dimethylphenyl]-3,3-dimethylbutanamide (Compound A), to the human in need thereof, for example, under fed conditions.
Gregory N. Beatch
Filed: 13 May 19
Utility
Therapeutic compounds and methods of use thereof
28 Sep 21
Ivan William Hemeon, Brian Salvatore Safina, Daniel Sutherlin
Filed: 15 Nov 19
Utility
Solid state crystalline forms of a selective potassium channel modulator
17 Aug 21
The present disclosure provides solid state forms of a selective potassium channel modulator and pharmaceutical compositions comprising the solid state crystalline forms and pharmaceutically acceptable excipients, and methods for preparing and using the solid state forms and the pharmaceutical compositions thereof.
Paul Robert Bichler, Jean-Jacques Alexandre Cadieux, Matthew David Tandy, Gregory N. Beatch
Filed: 13 Oct 20
Utility
Substituted benzamides useful as sodium channel blockers
26 Jan 21
Chien-an Chen, Sultan Chowdhury, Shannon Marie Decker, Christoph Martin Dehnhardt, Ivan William Hemeon, Steven McKerrall, Brian Salvatore Safina, Tao Sheng, Dan Sutherlin
Filed: 22 Nov 16
Utility
Benzenesulfonamide compounds and their use as therapeutic agents
26 Oct 20
This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.
Kristen Nicole Burford, Sultan Chowdhury, Christoph Martin Dehnhardt, Thilo Focken, Michael Edward Grimwood, Syed Abid Hasan
Filed: 16 Mar 20
Utility
Therapeutic compounds and methods of use thereof
28 Sep 20
Philippe Bergeron, Kristen Burford, Sultan Chowdhury, Christoph Martin Dehnhardt, Thilo Focken, Michael Edward Grimwood, Abid Hasan, Kwong Wah Lai, Zhiguo Liu, Steven McKerrall, Teresa Phuongtram Nguyen, Brian Safina, Daniel Sutherlin, Tao Wang
Filed: 27 Mar 18
Utility
Substituted benzamides and methods of use thereof
7 Sep 20
Sultan Chowdhury, Christoph Martin Dehnhardt, Thilo Focken, Michael Edward Grimwood, Ivan William Hemeon, Steven McKerrall, Daniel Sutherlin
Filed: 27 Mar 17
Utility
Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors
24 Aug 20
This invention is directed to heteroaryl-substituted sulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.
Jean-Christophe Andrez, Kristen Nicole Burford, Christoph Martin Dehnhardt, Thilo Focken, Michael Edward Grimwood, Qi Jia, Verner Alexander Lofstrand, Steven Sigmund Wesolowski, Michael Scott Wilson
Filed: 28 Aug 19
Utility
Benzenesulfonamide compounds and their use as therapeutic agents
17 Aug 20
This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.
Kristen Nicole Burford, Thilo Focken, Verner Alexander Lofstrand, Michael Scott Wilson, Alla Yurevna Zenova
Filed: 12 Jun 19
Utility
Benzenesulfonamide compounds and their use as therapeutic agents
25 May 20
This invention is directed to methods of preparing benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.
Jean-Christophe Andrez, Kristen Nicole Burford, Sultan Chowdhury, Charles Jay Cohen, Christoph Martin Dehnhardt, Robert Joseph Devita, James Roy Empfield, Thilo Focken, Michael Edward Grimwood, Syed Abid Hasan, James Philip Johnson, Jr., Alla Yurevna Zenova
Filed: 27 Feb 19
Utility
Therapeutic compounds and methods of use thereof
6 Jan 20
Jean-Christophe Andrez, Philippe Bergeron, Paul Robert Bichler, Sultan Chowdhury, Christoph Martin Dehnhardt, Thilo Focken, Wei Gong, Michael Edward Grimwood, Abid Hasan, Ivan William Hemeon, Qi Jia, Brian Salvatore Safina, Shaoyi Sun, Michael Scott Wilson, Alla Yurevna Zenova
Filed: 1 Oct 18
Utility
Solid state forms of spiro-oxindole compounds
23 Dec 19
The present invention provides solid state forms of certain spiro-oxindole compounds, such as funapide and the racemic mixture of funapide and its corresponding (R) enantiomer, pharmaceutical compositions comprising the solid state forms and processes for preparing the solid state forms and the pharmaceutical compositions.
Ronen Ben-David, Stephen Bierlmaier, Ralph Curtis Haltiwanger, Alexandr Jegorov, Raeann Ruiyun Wu, Mehran Yazdanian
Filed: 9 Oct 18
Utility
Therapeutic compounds and methods of use thereof
28 Oct 19
Daniel Sutherlin, Steven McKerrall, Michael Scott Wilson, Kwong Wah Lai, Philippe Bergeron, Birong Zhang, Ramsay Beveridge, Jean-Philippe Leclerc, Alexandre Lemire, Liang Zhao, Claudio Sturino
Filed: 30 Oct 17
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