41 patents
Utility
Compositions and methods for intrathecal administration of MCOPPB for pain relief
16 Jan 24
The invention provides compositions and methods for intrathecal administration of the compound MCOPPB or a pharmaceutically acceptable salt thereof for treating pain, such as neuropathic pain suffered by an adult human.
James N. Campbell, Barton Harley Manning
Filed: 24 May 21
Utility
Capsaicinoid prodrug compounds and their use in treating medical conditions
21 Nov 23
The invention provides capsaicinoid prodrug compounds, pharmaceutical compositions, and their use in the treatment of medical conditions, such as pain, and in agonizing TRPV1 activity.
James N. Campbell, Scott M. Duncan
Filed: 29 Jun 22
Utility
CCR2 receptor antagonists and uses thereof
22 Aug 23
The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD.
Heiner Ebel, Sara Frattini, Kai Gerlach, Riccardo Giovannini, Christoph Hoenke, Rocco Mazzaferro, Marco Santagostino, Stefan Scheuerer, Christofer Tautermann, Thomas Trieselmann
Filed: 11 Jun 21
Utility
(Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
15 Aug 23
This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the treatment of CB2 receptor mediated disorders or conditions.
Doris Riether, Florian Paul Christian Binder, Henri Doods, Stephan Georg Mueller, Janet Rachel Nicholson, Achim Sauer
Filed: 10 Aug 21
Utility
High concentration local anesthetic formulations
6 Dec 22
A transdermal topical anesthetic formulation, which can be used to ameliorate or inhibit pain, has been developed.
James N. Campbell, Arthur F. Michaelis
Filed: 27 Aug 20
Utility
Capsaicinoid prodrug compounds and their use in treating medical conditions
20 Sep 22
The invention provides capsaicinoid prodrug compounds, pharmaceutical compositions, and their use in the treatment of medical conditions, such as pain, and in agonizing TRPV1 activity.
James N. Campbell, Scott M. Duncan
Filed: 17 Jan 20
Utility
Stable aqueous capsaicin injectable formulations and medical uses thereof
31 May 22
The invention provides stable, aqueous capsaicin injectable formulations, a unit dose containing such injectable formulations, medical kits, and methods for using such injectable formulations and unit doses to treat patients suffering from pain, such as osteoarthritic knee pain.
Drazen Ostovic, Gary Fred Musso
Filed: 11 Sep 20
Utility
Novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]THIADIAZOLES
5 May 22
This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the treatment of CB2 receptor mediated disorders or conditions.
Doris Riether, Florian Paul Christian Binder, Henri Doods, Stephan Georg Mueller, Janet Rachel Nicholson, Achim Sauer
Filed: 10 Aug 21
Utility
(4-((3R,4R)-3-METHOXYTETRAHYDRO-PYRAN-4-YLAMINO)PIPERIDIN-1-YL)(5-METHYL-6-(((2R,6S)-6-(P-TOLYL)TETRAHYDRO-2H-PYRAN-2-YL)METHYLAMINO)PYRIMIDIN-4-YL)METHANONE Citrate
5 May 22
The invention provides a salt of a tetrahydropyranylmethylaminopyrimidine amide, such as the citrate salt of (4-((3R,4R)-3-methoxytetrahydropyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2R,6S)-6-(p-tolyl)tetrahydro-2H-pyran-2-yl)methylamino)pyrimidin-4-yl)methanone, pharmaceutical compositions containing the same, processes for preparing the same, and methods of medical treatment using the same.
Markus Ostermeier, Ulrike Warthmann
Filed: 13 Oct 21
Utility
Capsaicinoid prodrug compounds and their use in treating medical conditions
22 Feb 22
The invention provides capsaicinoid prodrug compounds (e.g., prodrugs of resiniferatoxin, tinyatoxin, iodoresiniferatoxin, and related compounds), pharmaceutical compositions, and their use in the treatment of medical conditions, such as pain, and in agonizing TRPV1 activity.
James N. Campbell, Scott M. Duncan
Filed: 17 Jan 20
Utility
CCR2 Receptor Antagonists and Uses Thereof
6 Jan 22
The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD.
Heiner Ebel, Sara Frattini, Kai Gerlach, Riccardo Giovannini, Christoph Hoenke, Rocco Mazzaferro, Marco Santagostino, Stefan Scheuerer, Christofer Tautermann, Thomas Trieselmann
Filed: 11 Jun 21
Utility
Compositions and Methods for Intrathecal Administration of Mcoppb for Pain Relief
16 Dec 21
The invention provides compositions and methods for intrathecal administration of the compound MCOPPB or a pharmaceutically acceptable salt thereof for treating pain, such as neuropathic pain suffered by an adult human.
James N. Campbell, Barton Harley Manning
Filed: 24 May 21
Utility
Methods and Compositions for Treating a Coronavirus Infection
21 Oct 21
The invention provides methods, compositions, and kits for using substituted (4-(amino)piperidin-1-yl)(6-(((tetrahydro-2H-pyran-2-yl)methyl)amino)pyrimidin-4-yl)methanone compounds to treat a coronavirus infection and related medical conditions.
James N. Campbell, Randall Stevens
Filed: 20 Apr 21
Utility
(4-((3R,4R)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2R,6S)-6-(p- tolyl)tetrahydro-2H-pyran-2-yl)methylamino)pyrimidin-4-yl)methanone citrate
19 Oct 21
The invention provides a salt of a tetrahydropyranylmethylaminopyrimidine amide, such as the citrate salt of (4-((3R,4R)-3-methoxytetrahydropyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2R,6S)-6-(p-tolyl)tetrahydro-2H-pyran-2-yl)methylamino)pyrimidin-4-yl)methanone, pharmaceutical compositions containing the same, processes for preparing the same, and methods of medical treatment using the same.
Markus Ostermeier, Ulrike Werthmann
Filed: 11 Feb 20
Utility
Methods and Compositions for Treatment of Pain Using Capsaicin
30 Sep 21
The invention provides methods and compositions for treatment of pain, such as joint pain, using capsaicin in a procedure that attenuates transient burning sensation experienced by patients due to capsaicin administration.
James N. Campbell, Peter D. Hanson, Randall Stevens
Filed: 4 Jun 21
Utility
(Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
10 Aug 21
This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the treatment of CB2 receptor mediated disorders or conditions.
Doris Riether, Florian Paul Christian Binder, Henri Doods, Stephan Georg Mueller, Janet Rachel Nicholson, Achim Sauer
Filed: 22 Jan 20
Utility
Compositions and methods for intrathecal administration of MCOPPB for pain relief
29 Jun 21
The invention provides compositions and methods for intrathecal administration of the compound MCOPPB or a pharmaceutically acceptable salt thereof for treating pain, such as neuropathic pain suffered by an adult human.
James N. Campbell, Barton Harley Manning
Filed: 1 Oct 19
Utility
CCR2 receptor antagonists and uses thereof
29 Jun 21
The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD.
Heiner Ebel, Sara Frattini, Kai Gerlach, Riccardo Giovannini, Christoph Hoenke, Rocco Mazzaferro, Marco Santagostino, Stefan Scheuerer, Christofer Tautermann, Thomas Trieselmann
Filed: 27 Dec 18
Utility
High Concentration Local Anesthetic Formulations
17 Jun 21
A transdermal topical anesthetic formulation, which can be used to ameliorate or inhibit pain, has been developed.
James N. Campbell, Arthur F. Michaelis
Filed: 27 Aug 20
Utility
Methods and compositions for treatment of pain using capsaicin
8 Jun 21
The invention provides methods and compositions for treatment of pain, such as joint pain, using capsaicin in a procedure that attenuates transient burning sensation experienced by patients due to capsaicin administration.
James N. Campbell, Peter D. Hanson, Randall Stevens
Filed: 4 Aug 20