12 patents
Utility
Combination therapy involving diaryl macrocyclic compounds
23 May 23
The present disclosure relates to methods and compositions for treating cancer with a diaryl macrocycle in combination with a KRAS inhibitor, such as an inhibitor of KRAS G12C.
Wei Deng, Dayong Zhai, Laura Rodon, Brion W. Murray, Jingrong J. Cui
Filed: 25 Nov 20
Utility
Macrocycles for use in treating disease
25 Apr 23
The present disclosure relates to certain chiral diaryl macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat cancer.
Evan W. Rogers, Jane Ung, Vivian Nguyen, Dayong Zhai, Wei Deng, Jingrong J. Cui
Filed: 2 Dec 20
Utility
Chiral diaryl macrocycles and uses thereof
27 Sep 22
This disclosure relates to the use of certain diaryl macrocycle compounds, specifically (7S13R)-11-fluoro-7,13-di-methyl-6,7,13,14-tetrahydro-1,15-ethenopyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one in the treatment of disease in mammals.
Jingrong J. Cui, Yishan Li, Evan W. Rogers, Dayong Zhai, Wei Deng, Zhongdong Huang
Filed: 20 Aug 20
Utility
Combination therapy involving diaryl macrocyclic compounds
5 Apr 22
The present disclosure relates to methods and compositions for treating cancer with a diaryl macrocycle in combination with at least one other cancer therapeutic, such as an EGFR inhibitor.
Jingrong Jean Cui, Dayong Zhai
Filed: 25 Jan 18
Utility
Macrocyclic compounds and uses thereof
29 Mar 22
The present disclosure relates to certain macrocyclic compounds that inhibit SRC and MET, and/or CSF1R, pharmaceutical compositions containing such compounds, and methods of using such compounds to treat cancer.
Jingrong Jean Cui, Evan W. Rogers, Jane Ung, Jeffrey Whitten, Dayong Zhai, Wei Deng, Xin Zhang, Zhongdong Huang, Jing Liu, Han Zhang
Filed: 26 Jul 18
Utility
Macrocyclic compounds for treating disease
29 Mar 22
The present disclosure relates to certain macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat disease, such as cancer.
Evan W. Rogers, Jingrong J. Cui, Dayong Zhai, Han Zhang, Jane Ung, Wei Deng, Jeffrey Whitten
Filed: 5 May 20
Utility
Macrocyclic compounds and uses thereof
26 Oct 21
The present disclosure relates to certain macrocyclic compounds that inhibit SRC and MET, and/or CSF1R, pharmaceutical compositions containing such compounds, and methods of using such compounds to treat cancer.
Jingrong Jean Cui, Evan W. Rogers, Jane Ung, Jeffrey Whitten, Dayong Zhai, Wei Deng, Xin Zhang, Zhongdong Huang, Jing Liu, Han Zhang
Filed: 25 Mar 21
Utility
Macrocycles for use in treating disease
12 Oct 21
The present disclosure relates to certain chiral diaryl macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat cancer.
Evan W. Rogers, Jane Ung, Vivian Nguyen, Dayong Zhai, Wei Deng, Jingrong J. Cui
Filed: 26 Mar 21
Utility
Chiral diaryl macrocycles as modulators of protein kinases
18 May 21
Jingrong J. Cui, Yishan Li, Evan W. Rogers, Dayong Zhai, Wei Deng, Jane Ung
Filed: 29 May 19
Utility
Macrocyclic compounds for treating disease
17 Aug 20
The present disclosure relates to certain macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat disease, such as cancer.
Evan W. Rogers, Jingrong J. Cui, Dayong Zhai, Han Zhang, Jane Ung, Wei Deng, Jeffrey Whitten
Filed: 29 Jan 20
Utility
Macrocycle kinase inhibitors
22 Jun 20
The present disclosure relates to certain macrocyclic kinase inhibitors, pharmaceutical compositions containing the same, and methods of using the same to treat disease.
Jingrong Jean Cui, Yishan Li, Evan W. Rogers, Dayong Zhai, Jane Ung
Filed: 26 Jul 17
Utility
Diaryl macrocycles as modulators of protein kinases
13 Apr 20
The present invention relates to certain diaryl macrocyclic compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating cancer, pain, neurological diseases, autoimmune diseases, and inflammation.
Jingrong Jean Cui, Yishan Li, Evan W. Rogers, Dayong Zhai
Filed: 28 Nov 18
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