9 patents
Utility
Methods of Preparing a Primary Cell Sample
27 Jul 23
The invention provides methods of preparing a sample of viable diseased cells obtained from a human subject for clinical testing, wherein the methods inhibit anoikis and/or anoikis in the cells while maintaining the physiological functions and genomic composition of the cells when they were in vivo.
Lance Gavin LAING, Ben RICH, Abhijit DANDAPAT
Filed: 23 Jan 23
Utility
Methods of Measuring Signaling Pathway Activity for Selection of Therapeutic Agents
27 Apr 23
Provided herein are methods for simultaneously determining the functional status of multiple signaling pathways in a diseased cell sample obtained from a subject to thereby select for therapeutic use in the subject a targeted therapeutic agent that affects the signaling pathway with the highest level of aberrant activity in the subject's cells.
Lance Gavin LAING, Brian Francis SULLIVAN
Filed: 13 Apr 22
Utility
Methods of preparing a primary cell sample
28 Feb 23
The invention provides methods of preparing a sample of viable diseased cells obtained from a human subject for clinical testing, wherein the methods inhibit anoikis and/or anoikis in the cells while maintaining the physiological functions and genomic composition of the cells when they were in vivo.
Lance Gavin Laing, Ben Rich, Abhijit Dandapat
Filed: 11 Apr 18
Utility
Methods for the Treatment of Cancer Using 1-(4-{[4-(DIMETHYLAMINO)PIPERIDIN-1-YL]CARBONYL}PHENYL)-3-[4-(4,6-DIMORPHOLIN-4-YL-1,3,5-TRIAZIN-2-YL)PHENYL]UREA
26 Jan 23
Provided are methods of treating cancer in a human subject.
Brian Francis SULLIVAN, Lance Gavin LAING
Filed: 25 Jul 22
Utility
Methods of Treating Cancer Patients with Ras Node or RTK Targeted Therapeutic Agents
29 Dec 22
Provided herein are methods for determining the functional status of G-protein coupled receptor (GPCR) signaling pathways in a diseased cell sample obtained from a subject to thereby select for therapeutic use in the subject a RAS node or receptor tyrosine kinase (RTK) targeted therapeutic.
Lance Gavin LAING, Salmaan Ahmed KHAN, Brian Francis SULLIVAN
Filed: 8 Jun 22
Utility
Methods of measuring signaling pathway activity for selection of therapeutic agents
17 May 22
Provided herein are methods for simultaneously determining the functional status of multiple signaling pathways in a diseased cell sample obtained from a subject to thereby select for therapeutic use in the subject a targeted therapeutic agent that affects the signaling pathway with the highest level of aberrant activity in the subject's cells.
Lance Gavin Laing, Brian Francis Sullivan
Filed: 29 Aug 18
Utility
Assays and methods for determining the responsiveness of an individual subject to a therapeutic agent
27 Jul 21
Provided herein are methods for determining the functional status of a cellular pathway in a diseased cell sample obtained from an individual subject.
Lance Gavin Laing, Brian Francis Sullivan
Filed: 10 Jun 16
Utility
Whole Cell Assays and Methods
15 Jul 21
The disclosure provides methods for analysis of disease cell response to a therapeutic agent.
Lance Gavin Laing, Brian Francis Sullivan
Filed: 5 Mar 21
Utility
Whole cell assays and methods
13 Apr 21
The disclosure provides methods for analysis of disease cell response to a therapeutic agent.
Lance Gavin Laing, Brian Francis Sullivan
Filed: 3 Jul 18
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