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SQZ Biotechnologies (SQZ)

Utility
Intracellular Delivery of Biomolecules to Enhance Antigen Presenting Cell Function
16 Dec 21
The present application provides enhanced antigen presenting cells comprising an agent that enhances the viability and/or function of the antigen presenting cell and/or an antigen and/or an adjuvant, methods of manufacturing such modified antigen presenting cells, and methods of using such modified antigen presenting cells, such as for modulating an immune response in an individual.
Howard BERNSTEIN, Matt BOOTY, Luke CASSEREAU, Jonathan CHOW, Kelan HLAVATY, Scott LOUGHHEAD, Melissa MYINT, Scott SAUER, Armon SHAREI, Vidhya VIJAYAKUMAR
Filed: 3 Oct 19
Utility
Point of Care System for Automatically Processing Cells
25 Nov 21
The present disclosure generally relates to a systems and methods for processing cells, and kits for use with such methods and processes.
Maisam DADGAR, Tarek ABDELJAWAD, Howard BERNSTEIN
Filed: 21 May 21
Utility
Intracellular Delivery of Biomolecules to Modulate Antibody Production
14 Oct 21
The present invention provides methods and systems for modulating antibody production by passing a cell suspension through a constriction, wherein the constriction deforms the cell thereby causing a perturbation of the cell such that a compound that modulates antibody production enters the cell.
Armon R. SHAREI, Jonathan B. GILBERT
Filed: 4 Dec 18
Utility
Intracellular Delivery of Biomolecules to Induce Tolerance
13 May 21
The present invention provides methods for inducing tolerance or suppressing an immune response to an antigen by passing a cell suspension containing an immune cell through a constriction, wherein the constriction deforms the cell thereby causing a perturbation of the cell such that an antigen and/or tolerogenic factor enters the cell, thereby generating a tolerogenic and/or immunosuppressive immune cell.
Scott LOUGHHEAD, Jonathan B. GILBERT, Howard BERNSTEIN, Armon R. SHAREI, Finola MOORE
Filed: 3 May 17
Utility
Intracellular Delivery of Biomolecules to Modify Immune Response
22 Apr 21
Provided herein are methods and compositions related to bacteria of genus Burkholderia useful as therapeutic agents.
Scott LOUGHHEAD, LeeAnn TALARICO, Alfonso VICENTE-SUAREZ, Matt BOOTY, Howard BERNSTEIN, Katarina BLAGOVIC, Armon R. SHAREI, Kelan HLAVATY
Filed: 12 Mar 19
Utility
Methods for Treating Hpv-associated Diseases
11 Feb 21
The present application provides immune cells comprising an HPV antigen and an adjuvant, methods of manufacturing such modified immune cells, and methods of using such modified immune cells for treating an HPV-associated disease, preventing an HPV-associated disease and/or for modulating an immune response in an individual with an HPV-associated disease.
Scott LOUGHHEAD, LeeAnn TALARICO, Alfonso VICENTE-SUAREZ, Matt BOOTY, Howard BERNSTEIN, Katarina BLAGOVIC, Armon R. SHAREI, Kelan HLAVATY, Melissa MYINT
Filed: 11 Mar 19
Utility
System for Delivery of a Payload into a Cell
21 Oct 20
A system for delivering a payload to a cell that includes: a platform supporting an input container, an output container, and a receiver for receiving all or part of a disposable assembly, the disposable assembly including a preparation vessel and a constriction cartridge.
Maisam DADGAR, Tarek ABDELJAWAD, Howard BERNSTEIN
Filed: 17 Dec 18
Utility
Cartridge for Use In a System for Delivery of a Payload into a Cell
7 Oct 20
A cartridge for delivering a payload to cells of a cell suspension is provided, wherein the cartridge comprises an input channel that delivers the cell suspension to a first plurality of branch channels, and wherein the first plurality of branch channels each deliver the cell suspension into a respective one or a plurality of microfluidic chips or filters.
Maisam DADGAR
Filed: 5 Apr 20
Utility
DELIVERY OF BIOMOLECULES TO PBMCs TO MODIFY AN IMMUNE RESPONSE
7 Oct 20
The present application provides peripheral blood mononuclear cells comprising an antigen, methods of manufacturing such PBMCs, and methods of using such PBMCs, such as for modulating an immune response in an individual.
Armon R. SHAREI, Howard BERNSTEIN, Scott LOUGHHEAD, Matthew BOOTY, Katarina BLAGOVIC, Kelan HLAVATY, Defne YARAR, Emrah Ilker OZAY, Carolyne Kelly SMITH
Filed: 26 Feb 20
Utility
Intracellular Delivery of Biomolecules Mediated by a Surface with Pores
18 Dec 19
The present disclosure pertains to methods and devices for delivering a compound into a cell, including passing a cell suspension through a surface containing pores, wherein the pores deform the cell thereby causing a perturbation of the cell such that the compound enters the cell, wherein the cell suspension is contacted with the compound.
Jonathan B. GILBERT, Kirubel FREW, Howard BERNSTEIN, Armon R. SHAREI
Filed: 1 Sep 16
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