154 patents
Utility
System and Method for Cleaning Noisy Genetic Data and Determining Chromosome Copy Number
4 Jan 24
Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available.
Matthew RABINOWITZ, Milena BANJEVIC, Zachary DEMKO, David JOHNSON, Dusan KIJACIC, Dimitri PETROV, Joshua SWEETKIND-SINGER, Jing XU
Filed: 7 Sep 23
Utility
Methods for Non-invasive Prenatal Ploidy Calling
28 Dec 23
The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father.
Matthew RABINOWITZ, George GEMELOS, Milena BANJEVIC, Allison RYAN, Zachary DEMKO, Matthew HILL, Bernhard ZIMMERMANN, Johan BANER
Filed: 7 Sep 23
Utility
Methods for Simultaneous Amplification of Target Loci
30 Nov 23
The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods.
Matthew RABINOWITZ, Matthew HILL, Bernhard ZIMMERMANN, George GEMELOS, Johan BANER, Milena BANJEVIC, Allison RYAN, Styrmir SIGURJONSSON, Zachary DEMKO
Filed: 24 Mar 23
Utility
Methods for Non-invasive Prenatal Ploidy Calling
16 Nov 23
The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father.
Matthew RABINOWITZ, George GEMELOS, Milena BANJEVIC, Allison RYAN, Zachary DEMKO, Matthew HILL, Bernhard ZIMMERMANN, Johan BANER
Filed: 27 Jul 23
Utility
Methods for Non-invasive Prenatal Ploidy Calling
9 Nov 23
The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father.
Matthew RABINOWITZ, George GEMELOS, Milena BANJEVIC, Allison RYAN, Zachary DEMKO, Matthew HILL, Bernhard ZIMMERMANN, Johan BANER
Filed: 27 Jul 23
Utility
Methods for Non-invasive Prenatal Ploidy Calling
26 Oct 23
The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father.
Matthew RABINOWITZ, George GEMELOS, Milena BANJEVIC, Allison RYAN, Zachary DEMKO, Matthew HILL, Bernhard ZIMMERMANN, Johan BANER
Filed: 10 Jul 23
Utility
Compositions and Methods for Identifying Nucleic Acid Molecules
19 Oct 23
The present disclosure provides methods and compositions for sequencing nucleic acid molecules and identifying individual sample nucleic acid molecules using Molecular Index Tags (MITs).
Bernhard ZIMMERMANN, Ryan SWENERTON, Matthew RABINOWITZ, Styrmir SIGURJONSSON, George GEMELOS, Apratim GANGULY, Himanshu SETHI
Filed: 5 Dec 22
Utility
Methods for Detection of Donor-derived Cell-free Dna
14 Sep 23
The present disclosure provides methods for determining the status of an allograft within a transplant recipient from genotypic data measured from a mixed sample of DNA comprising DNA from both the transplant recipient and from the donor.
Solomon MOSHKEVICH, Bernhard ZIMMERMANN, Tudor Pompiliu CONSTANTIN, Huseyin Eser KIRKIZLAR, Allison RYAN, Styrmir SIGURJONSSON, Felipe ACOSTA ARCHILA, Ryan SWENERTON
Filed: 3 Jul 19
Utility
Methods for amplification of cell-free DNA using ligated adaptors and universal and inner target-specific primers for multiplexed nested PCR
5 Sep 23
Methods for non-invasive prenatal paternity testing are disclosed herein.
Matthew Rabinowitz, Matthew Hill, Bernhard Zimmermann, Johan Baner, George Gemelos, Milena Banjevic, Allison Ryan, Styrmir Sigurjonsson, Zachary Demko
Filed: 20 Feb 20
Utility
Detecting Mutations and Ploidy In Chromosomal Segments
3 Aug 23
The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants.
Joshua BABIARZ, Tudor Pompiliu CONSTANTIN, Lane A. EUBANK, George GEMELOS, Matthew Micah HILL, Huseyin Eser KIRKIZLAR, Matthew RABINOWITZ, Onur SAKARYA, Styrmir SIGURJONSSON, Bernhard ZIMMERMANN
Filed: 20 Feb 23
Utility
Materials and methods for processing blood samples
25 Jul 23
Provided herein are materials and methods relating to cell-free DNA.
Aoy Tomita Mitchell
Filed: 3 Apr 20
Utility
System and Method for Cleaning Noisy Genetic Data and Determining Chromosome Copy Number
6 Jul 23
Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available.
Matthew RABINOWITZ, Milena BANJEVIC, Zachary DEMKO, David JOHNSON, Dusan KIJACIC, Dimitri PETROV, Joshua SWEETKIND-SINGER, Jing XU
Filed: 13 Mar 23
Utility
Methods for Detection of Donor-derived Cell-free Dna
29 Jun 23
The present disclosure provides methods for quantifying the amount of total cell-free DNA in a biological sample, comprising: isolating cell-free DNA from the biological sample, wherein a first Tracer DNA composition is added before or after isolation of the cell-free DNA; performing targeted amplification at 100 or more different target loci in a single reaction volume using 100 or more different primer pairs; sequencing the amplification products by high-throughput sequencing to generate sequencing reads; and quantifying the amount of total cell-free DNA using sequencing reads derived from the first Tracer DNA composition.
Ryan SWENERTON, Bernhard ZIMMERMANN, Ebad AHMED, Nathan LIANG, Allison RYAN, Fei LU, Paul VAN HUMMELEN
Filed: 27 May 21
Utility
Methods for Characterizing Copy Number Variation Using Proximity-litigation Sequencing
2 Mar 23
Disclosed here is a method for detecting genome rearrangement in a biological sample, comprising: obtaining a contact matrix plotted from proximity ligation sequencing data of at least one chromosome; identifying an abnormal contact pattern in the contact matrix compared to the contact matrix of a reference genome; comparing the abnormal contact pattern in the contact matrix to one or more known patterns associated with genomic rearrangement to identify a type of genomic rearrangement causing the abnormal contact pattern.
Axel BETHKE
Filed: 31 Oct 22
Utility
Methods for amplification of cell-free DNA using ligated adaptors and universal and inner target-specific primers for multiplexed nested PCR
28 Feb 23
Methods for non-invasive prenatal paternity testing are disclosed herein.
Matthew Rabinowitz, Matthew Hill, Bernhard Zimmermann, Johan Baner, George Gemelos, Milena Banjevic, Allison Ryan, Styrmir Sigurjonsson, Zachary Demko
Filed: 20 Feb 20
Utility
Methods for Simultaneous Amplification of Target Loci
23 Feb 23
The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods.
Matthew RABINOWITZ, Matthew Micah HILL, Bernhard ZIMMERMANN, Johan BANER, George GEMELOS, Milena BANJEVIC, Allison RYAN, Styrmir SIGURJONSSON, Zachary DEMKO
Filed: 19 Jul 22
Utility
Methods for Non-invasive Prenatal Ploidy Calling
23 Feb 23
The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father.
Matthew RABINOWITZ, George GEMELOS, Milena BANJEVIC, Allison RYAN, Zachary DEMKO, Matthew HILL, Bernhard ZIMMERMANN, Johan BANER
Filed: 15 Sep 22
Utility
Detecting Mutations and Ploidy In Chromosomal Segments
9 Feb 23
The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants.
Joshua BABIARZ, Tudor Pompiliu CONSTANTIN, Lane A. EUBANK, George GEMELOS, Matthew Micah HILL, Huseyin Eser KIRKIZLAR, Matthew RABINOWITZ, Onur SAKARYA, Styrmir SIGURJONSSON, Bernhard ZIMMERMANN
Filed: 4 Oct 22
Utility
Methods for Simultaneous Amplification of Target Loci
29 Dec 22
The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods.
Matthew RABINOWITZ, Matthew Micah HILL, Bernhard ZIMMERMANN, Johan BANER, George GEMELOS, Milena BANJEVIC, Allison RYAN, Styrmir SIGURJONSSON, Zachary DEMKO
Filed: 19 Jul 22
Utility
Methods and Compositions for Determining Ploidy
22 Dec 22
The invention provides improved methods, compositions, and kits for detecting ploidy of chromosome regions, e.g. for detecting cancer or a chromosomal abnormality in a gestating fetus.
Huseyin Eser KIRKIZLAR, Raheleh SALARI, Styrmir SIGURJONSSON, Bernhard ZIMMERMANN, Allison RYAN, Naresh VANKAYALAPATI
Filed: 21 Jun 22