30 patents
Utility
Methods for Preventing and Treating Intra-abdominal Candidiasis
21 Dec 23
Provided herein are methods of identifying an individual having or at risk of developing intra-abdominal candidiasis (IAC) and treating, mitigating, or preventing IAC in the individual by administering a pharmaceutical composition including CD101, in salt or neutral form, in an amount sufficient to effectively treat or prevent IAC.
Kenneth BARTIZAL, Paul Daruwala, Voon Ong, Taylor Sandison
Filed: 20 Jan 23
Utility
Compositions and Methods for the Treatment of Viral Infections
14 Dec 23
Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide.
Allen BORCHARDT, Thomas P. BRADY, Zhi-Yong CHEN, Thanh LAM, Leslie W. TARI
Filed: 15 Aug 22
Utility
Compositions and methods for the treatment of viral infections
5 Dec 23
Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide.
James M. Balkovec, Daniel C. Bensen, Allen Borchardt, Thomas P. Brady, Zhi-Yong Chen, Jason Cole, Quyen-Quyen Thuy Do, Simon Doehrmann, Wanlong Jiang, Thanh Lam, Alain Noncovich, Leslie W. Tari
Filed: 21 Apr 21
Utility
Compositions and methods for the treatment of fungal infections
21 Nov 23
The disclosure features non-irritating pharmaceutical compositions containing CD101 in pharmaceutical acceptable salt (e.g., CD101 acetate) or neutral form.
Kenneth Bartizal, Paul Daruwala, David Hughes, Martin Patrick Hughes, Navdeep B. Malkar, Balasingam Radhakrishnan, Anuradha Vaidya
Filed: 1 Dec 21
Utility
Synthesis of Echinocandin Antifungal Agent
16 Nov 23
The present invention relates to echinocandin cyclopeptides and to methods for preparing echinocandin cyclopeptides.
David HUGHES, Martin Patrick HUGHES, Balasingam RADHAKRISHNAN, Robert Michael HUGHES, Yannick BORGUET, Steven MCINTYRE
Filed: 8 Dec 22
Utility
Methods for the Synthesis of Protein-drug Conjugates
16 Nov 23
The present invention relates to intermediates and methods for synthesizing protein-drug conjugates that can be used for the treatment of diseases and related conditions.
Allen BORCHARDT, Robert Michael HUGHES
Filed: 6 Aug 21
Utility
Dosing regimens for treatment of fungal infections
1 Aug 23
The disclosure features pharmaceutical compositions, methods, and kits featuring dosing regimens and CD101, or a pharmaceutical acceptable salt or neutral form thereof (e.g., CD101 acetate).
Kenneth Bartizal, Paul Daruwala, Jeffrey Brian Locke, Voon Ong, Taylor Sandison, Dirk Thye
Filed: 15 Mar 17
Utility
Dosing regimens for echinocandin class compounds
23 May 23
The invention features pharmaceutical compositions, methods, and kits featuring dosing gimens and oral dosage formulations for administration of echinocandin class compounds.
Balasingam Radhakrishnan, Kenneth Duke James, Jr., Anuradha Vaidya, Karen Polowy
Filed: 2 Jul 20
Utility
Compositions and Methods for the Treatment of Human Immunodeficiency Virus
16 Mar 23
Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral gp120 receptor (e.g., temsavir, BMS-818251, DMJ-ll-121, BNM-IV-147, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide.
Allen BORCHARDT, Thomas P. BRADY, Zhi-Yong CHEN, Quyen-Quyen Thuy DO, Wanlong JIANG, Leslie W. TARI
Filed: 12 Jun 20
Utility
Compositions and Methods for the Treatment of Respiratory Syncytial Virus
16 Mar 23
Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral RSV F protein (e.g., Presatovir, MDT 637, JNJ 179, or an analog thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide.
Allen BORCHARDT, Thomas P. BRADY, Zhi-Yong CHEN, Quyen-Quyen Thuy DO, Travis James HAUSSENER, Alain NONCOVICH, Leslie W. TARI
Filed: 12 Jun 20
Utility
Synthesis of echinocandin antifungal agent
13 Dec 22
The present invention relates to echinocandin cyclopeptides and to methods for preparing echinocandin cyclopeptides.
David Hughes, Martin Patrick Hughes, Robert Michael Hughes, Balasingam Radhakrishnan, Yannick Borguet, Steven McIntyre
Filed: 14 Jun 19
Utility
Compositions and methods for the treatment of viral infections
29 Nov 22
Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide.
Allen Borchardt, Thomas P. Brady, Zhi-Yong Chen, Thanh Lam, Leslie W. Tari
Filed: 21 Apr 21
Utility
Compositions and Methods for the Treatment of Fungal Infections
13 Oct 22
The disclosure features non-irritating pharmaceutical compositions containing CD101 in pharmaceutical acceptable salt (e.g., CD101 acetate) or neutral form.
Kenneth BARTIZAL, Paul DARUWALA, David HUGHES, Martin Patrick HUGHES, Navdeep B. MALKAR, Balasingam RADHAKRISHNAN, Anuradha VAIDYA
Filed: 1 Dec 21
Utility
Compositions and Methods for the Treatment of Viral Infections
18 Aug 22
Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide.
James M. BALKOVEC, Daniel C. BENSEN, Allen BORCHARDT, Thomas P. BRADY, Zhi-Yong CHEN, Jason COLE, Quyen-Quyen Thuy DO, Simon DOEHRMANN, Wanlong JIANG, Thanh LAM, Alain NONCOVICH, Leslie W. TARI
Filed: 21 Apr 21
Utility
Variant FC Domains and Uses Thereof
9 Jun 22
This disclosure relates to variant Fc domain monomers, fusion proteins, conjugates, compositions, and related methods for treating or preventing disease.
Leslie W. TARI
Filed: 18 Feb 22
Utility
Antifungal Agents and Uses Thereof
26 May 22
The invention features echinocandin class compounds.
Kenneth Duke JAMES, JR., Christopher Patrick LAUDEMAN, Navdeep Balkrishna MALKAR, Balasingam RADHAKRISHNAN
Filed: 1 Jul 21
Utility
Compositions and methods for the treatment of fungal infections
14 Dec 21
The disclosure features non-irritating pharmaceutical compositions containing CD101 in pharmaceutical acceptable salt (e.g., CD101 acetate) or neutral form.
Kenneth Bartizal, Paul Daruwala, David Hughes, Martin Patrick Hughes, Navdeep B. Malkar, Balasingam Radhakrishnan, Anuradha Vaidya
Filed: 11 Jul 18
Utility
Polymorph of Echinocandin Antifungal Agent
18 Nov 21
The present invention relates to crystalline polymorphs of an echinocandin antifungal agent and novel methods for their preparation.
Martin Patrick HUGHES, Robert Michael HUGHES, Yannick BORGUET, Cen CHEN, Jianwei SHEN, Alan THOMPSON, Tracy WALKER, Yanfeng ZHANG
Filed: 25 Oct 19
Utility
Compositions and Methods for the Treatment of Viral Infections
29 Jul 21
Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide.
James M. BALKOVEC, Daniel C. BENSEN, Allen BORCHARDT, Thomas P. BRADY, Zhi-Yong CHEN, Jason COLE, Quyen-Quyen Thuy DO, Simon DOEHRMANN, Wanlong JIANG, Thanh LAM, Alain NONCOVICH, Leslie W. TARI
Filed: 5 Mar 21
Utility
Compositions and Methods for the Treatment of Viral Infections
22 Jul 21
Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide.
James M. BALKOVEC, Daniel C. BENSEN, Allen BORCHARDT, Thomas P. BRADY, Zhi-Yong CHEN, Jason COLE, Quyen-Quyen Thuy DO, Simon DOEHRMANN, Wanlong JIANG, Thanh LAM, Alain NONCOVICH, Leslie W. TARI
Filed: 5 Mar 21