21 patents
Utility
Methods for Preventing and Treating Intra-abdominal Candidiasis
21 Dec 23
Provided herein are methods of identifying an individual having or at risk of developing intra-abdominal candidiasis (IAC) and treating, mitigating, or preventing IAC in the individual by administering a pharmaceutical composition including CD101, in salt or neutral form, in an amount sufficient to effectively treat or prevent IAC.
Kenneth BARTIZAL, Paul Daruwala, Voon Ong, Taylor Sandison
Filed: 20 Jan 23
Utility
Compositions and Methods for the Treatment of Viral Infections
14 Dec 23
Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide.
Allen BORCHARDT, Thomas P. BRADY, Zhi-Yong CHEN, Thanh LAM, Leslie W. TARI
Filed: 15 Aug 22
Utility
Synthesis of Echinocandin Antifungal Agent
16 Nov 23
The present invention relates to echinocandin cyclopeptides and to methods for preparing echinocandin cyclopeptides.
David HUGHES, Martin Patrick HUGHES, Balasingam RADHAKRISHNAN, Robert Michael HUGHES, Yannick BORGUET, Steven MCINTYRE
Filed: 8 Dec 22
Utility
Methods for the Synthesis of Protein-drug Conjugates
16 Nov 23
The present invention relates to intermediates and methods for synthesizing protein-drug conjugates that can be used for the treatment of diseases and related conditions.
Allen BORCHARDT, Robert Michael HUGHES
Filed: 6 Aug 21
Utility
Compositions and Methods for the Treatment of Human Immunodeficiency Virus
16 Mar 23
Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral gp120 receptor (e.g., temsavir, BMS-818251, DMJ-ll-121, BNM-IV-147, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide.
Allen BORCHARDT, Thomas P. BRADY, Zhi-Yong CHEN, Quyen-Quyen Thuy DO, Wanlong JIANG, Leslie W. TARI
Filed: 12 Jun 20
Utility
Compositions and Methods for the Treatment of Respiratory Syncytial Virus
16 Mar 23
Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral RSV F protein (e.g., Presatovir, MDT 637, JNJ 179, or an analog thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide.
Allen BORCHARDT, Thomas P. BRADY, Zhi-Yong CHEN, Quyen-Quyen Thuy DO, Travis James HAUSSENER, Alain NONCOVICH, Leslie W. TARI
Filed: 12 Jun 20
Utility
Compositions and Methods for the Treatment of Fungal Infections
13 Oct 22
The disclosure features non-irritating pharmaceutical compositions containing CD101 in pharmaceutical acceptable salt (e.g., CD101 acetate) or neutral form.
Kenneth BARTIZAL, Paul DARUWALA, David HUGHES, Martin Patrick HUGHES, Navdeep B. MALKAR, Balasingam RADHAKRISHNAN, Anuradha VAIDYA
Filed: 1 Dec 21
Utility
Compositions and Methods for the Treatment of Viral Infections
18 Aug 22
Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide.
James M. BALKOVEC, Daniel C. BENSEN, Allen BORCHARDT, Thomas P. BRADY, Zhi-Yong CHEN, Jason COLE, Quyen-Quyen Thuy DO, Simon DOEHRMANN, Wanlong JIANG, Thanh LAM, Alain NONCOVICH, Leslie W. TARI
Filed: 21 Apr 21
Utility
Variant FC Domains and Uses Thereof
9 Jun 22
This disclosure relates to variant Fc domain monomers, fusion proteins, conjugates, compositions, and related methods for treating or preventing disease.
Leslie W. TARI
Filed: 18 Feb 22
Utility
Antifungal Agents and Uses Thereof
26 May 22
The invention features echinocandin class compounds.
Kenneth Duke JAMES, JR., Christopher Patrick LAUDEMAN, Navdeep Balkrishna MALKAR, Balasingam RADHAKRISHNAN
Filed: 1 Jul 21
Utility
Polymorph of Echinocandin Antifungal Agent
18 Nov 21
The present invention relates to crystalline polymorphs of an echinocandin antifungal agent and novel methods for their preparation.
Martin Patrick HUGHES, Robert Michael HUGHES, Yannick BORGUET, Cen CHEN, Jianwei SHEN, Alan THOMPSON, Tracy WALKER, Yanfeng ZHANG
Filed: 25 Oct 19
Utility
Compositions and Methods for the Treatment of Viral Infections
29 Jul 21
Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide.
James M. BALKOVEC, Daniel C. BENSEN, Allen BORCHARDT, Thomas P. BRADY, Zhi-Yong CHEN, Jason COLE, Quyen-Quyen Thuy DO, Simon DOEHRMANN, Wanlong JIANG, Thanh LAM, Alain NONCOVICH, Leslie W. TARI
Filed: 5 Mar 21
Utility
Compositions and Methods for the Treatment of Viral Infections
22 Jul 21
Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide.
James M. BALKOVEC, Daniel C. BENSEN, Allen BORCHARDT, Thomas P. BRADY, Zhi-Yong CHEN, Jason COLE, Quyen-Quyen Thuy DO, Simon DOEHRMANN, Wanlong JIANG, Thanh LAM, Alain NONCOVICH, Leslie W. TARI
Filed: 5 Mar 21
Utility
Synthesis of Echinocandin Antifungal Agent
17 Jun 21
The present invention relates to echinocandin cyclopeptides and to methods for preparing echinocandin cyclopeptides.
David HUGHES, Martin Patrick HUGHES, Robert Michael HUGHES, Balasingam RADHAKRISHNAN, Yannick BORGUET, Steven MCINTYRE
Filed: 14 Jun 19
Utility
Dosing Regimens for Echinocandin Class Compounds
6 May 21
The invention features pharmaceutical compositions, methods, and kits featuring dosing gimens and oral dosage formulations for administration of echinocandin class compounds.
Balasingam RADHAKRISHNAN, Kenneth Duke JAMES, JR., Anuradha VAIDYA, Karen POLOWY
Filed: 2 Jul 20
Utility
Methods for Preventing Fungal Infections
6 Jan 21
Provided herein are methods for preventing or reducing the likelihood of a fungal infection or related conditions thereto in a human subject in need thereof.
Kenneth BARTIZAL, Paul DARUWALA, Kevin FORREST, Brendan HANNAH, Voon ONG, Maureen RODEN, Taylor SANDISON
Filed: 28 Nov 17
Utility
Compositions and Methods for the Treatment of Fungal Infections
26 Aug 20
The disclosure features non-irritating pharmaceutical compositions containing CD101 in pharmaceutical acceptable salt (e.g., CD101 acetate) or neutral form.
Kenneth BARTIZAL, Paul DARUWALA, David HUGHES, Martin Patrick HUGHES, Navdeep B. MALKAR, Balasingam RADHAKRISHNAN, Anuradha VAIDYA
Filed: 10 Jul 18
Utility
Methods for Preventing and Treating Pneumocystis Infections
27 May 20
The disclosure relates to methods of prophylactic and therapeutic treatments of a Pneumocystis infection (i.e., an infection caused by Pneumocystis jirovecii) in a subject by administering to the subject a compound of any of formulas (I)-(III) (e.g., a salt of Compound 1, or a neutral form thereof).
Kenneth BARTIZAL, Paul DARUWALA, Voon ONG, Maureen RODEN, Taylor SANDISON, Dirk THYE
Filed: 31 Jul 19
Utility
Methods for Preventing and Treating Intra-abdominal Candidiasis
27 May 20
Provided herein are methods of identifying an individual having or at risk of developing intra-abdominal candidiasis (1AC) and treating, mitigating, or preventing 1AC in the individual by administering a pharmaceutical composition including CD1 01, in salt or neutral form, in an amount sufficient to effectively treat or prevent 1AC.
Kenneth BARTIZAL, Paul DARUWALA, Voon ONG, Taylor SANDISON
Filed: 22 Jan 18
Utility
Methods for Treating Fungal Infections
11 Dec 19
The invention relates to methods of treating dermatophytosis (e.g., onychomycosis) in a subject by subcutaneously administering to the subject CD101, in salt or neutral form.
Kenneth BARTIZAL, Paul DARUWALA
Filed: 30 Jan 18