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Wave Life Sciences (WVE)

Utility
Compositions and methods for phosphoramidite and oligonucleotide synthesis
9 Aug 22
The present disclosure, among other things, provides technologies for preparing and purifying phosphoramidites for oligonucleotide synthesis.
David Charles Donnell Butler, Subramanian Marappan, Ik-Hyeon Paik
Filed: 13 Mar 17
Utility
Oligonucleotide Compositions and Methods Thereof
23 Jun 22
Among other things, the present disclosure relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same.
Chandra Vargeese, Meena, Nenad Svrzikapa, Susovan Mohapatra, Christopher J. Francis, Gregory L. Verdine, Anna Sokolovska
Filed: 14 Jul 21
Utility
Oligonucleotide Compositions and Methods Thereof
16 Jun 22
Among other things, the present disclosure provides designed DMD oligonucleotides, compositions, and methods of use thereof.
Jason Jingxin Zhang, Chandra Vargeese, Naoki Iwamoto, Chikdu Shakti Shivalila, Nayantara Kothari, Ann Fiegen Durbin, Selvi Ramasamy, Pachamuthu Kandasamy, Jayakanthan Kumarasamy, Gopal Reddy Bommineni, Subramanian Marappan, Sethumadhavan Divakaramenon, David Charles Donnell Butler, Genliang Lu, Hailin Yang, Mamoru Shimizu, Prashant Monian, Khoa Ngoc Dang Luu
Filed: 6 Dec 19
Utility
Oligonucleotide Compositions and Methods Thereof
26 May 22
Among other things, the present disclosure relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same.
Chandra Vargeese, Meena, Nenad Svrzikapa, Susovan Mohapatra, Christopher J. Francis, Gregory L. Verdine, Anna Sokolovska
Filed: 7 May 20
Utility
Oligonucleotide Compositions and Methods of Use Thereof
12 May 22
Among other things, the present disclosure provides C9orf72 oligonucleotides, compositions, and methods thereof.
Yuanjing Liu, Naoki Iwamoto, Chandra Vargeese, Zhong Zhong, Amy Jada Andreucci
Filed: 8 May 20
Utility
Asymmetric Auxiliary Group
28 Apr 22
Mamoru Shimizu, Takeshi Wada
Filed: 2 Sep 21
Utility
Oligonucleotide Compositions and Methods Thereof
31 Mar 22
Among other things, the present disclosure provides oligonucleotides, compositions, and methods for preventing and/or treating various conditions, disorders or diseases.
Jeffrey Matthew Brown, Shaunna Syu-Mei Berkovitch, Naoki Iwamoto, Chandra Vargeese, Kidist M. Aklilu, Maria David Frank-Kamenetsky, Duncan Parley Brown
Filed: 30 Jan 20
Utility
Asymmetric auxiliary group
5 Oct 21
Mamoru Shimizu, Takeshi Wada
Filed: 19 May 20
Utility
Oligonucleotide Compositions and Methods of Use Thereof
19 Aug 21
Among other things, the present disclosure provides designed DMD oligonucleotides, compositions, and methods of use GC thereof.
Jason Jingxin Zhang, Chandra Vargeese, Naoki Iwamoto, Chikdu Shakti Shivalila, Nayantara Kothari, Ann Fiegen Durbin, Selvi Ramasamy, Pachamuthu Kandasamy, Jayakanthan Kumarasamy, Gopal Reddy Bommineni, Subramanian Marappan, Sethumadhavan Divakaramenon, David Charles Donnell Butler, Genliang Lu, Hailin Yang, Mamoru Shimizu, Prashant Monian
Filed: 10 May 19
Utility
Oligonucleotide Compositions and Methods Thereof
29 Jul 21
Among other things, the present disclosure provides technologies for altering splicing, particularly for increasing inclusion of exons in splicing products.
Jason Jingxin Zhang, Chikdu Shakti Shivalila, Chandra Vargeese, Naoki Iwamoto
Filed: 12 Oct 18
Utility
Oligonucleotide Compositions and Methods of Use Thereof
1 Jul 21
Among other things, the present disclosure provides designed APOC3 oligonucleotides, compositions, and methods thereof.
Chandra Vargeese, Naoki Iwamoto, David Charles Donnell Butler, Subramanian Marappan, Genliang Lu, Jason Jingxin Zhang, Vinod Vathipadiekal, Maria David Frank-Kamenetsky, Luciano Henrique Apponi, Hanna Maria Wisniewska, Xiayun Cheng, Young Jin Cho
Filed: 1 Jun 18
Utility
Oligonucleotides, compositions and methods thereof
25 May 21
The present disclosure pertains to the recognition that immune responses mediated by CpG oligonucleotides can be affected by the stereochemistry of modified internucleotidic linkages such as phosphorothioates.
Jason Jingxin Zhang, Naoki Iwamoto, Christopher J. Francis, Chandra Vargeese, David Charles Donnell Butler, Sethumadhavan Divakaramenon, Genliang Lu, Subramanian Marappan
Filed: 2 Jun 17
Utility
Chiral Control
6 May 21
The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same.
David Charles Donnell Butler, Naoki Iwamoto, Meena ., Nenad Svrzikapa, Gregory L. Verdine, Ivan Zlatev
Filed: 17 Dec 19
Utility
Chiral Design
22 Apr 21
The present invention relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same.
Meena, David Butler, Naoki Iwamoto, Nenad Svrzikapa, Gregory L. Verdine, Ivan Zlatev
Filed: 9 Sep 20
Utility
Oligonucleotide Compositions and Methods Thereof
4 Feb 21
Among other things, the present disclosure provides oligonucleotides, compositions, and methods thereof.
Chandra Vargeese, Zhong Zhong, Naoki Iwamoto, Jason Jingxin Zhang, Jean-Cosme Dodart, Yuanjing Liu, Pachamuthu Kandasamy, Sethumadhavan Divakaramenon, Genliang Lu, Subramanian Marappan
Filed: 7 Aug 18
Utility
Asymmetric Auxiliary Group
9 Dec 20
Mamoru Shimizu, Takeshi Wada
Filed: 18 May 20
Utility
Oligonucleotide Compositions and Methods Thereof
18 Nov 20
Among other things, the present disclosure provides oligonucleotides, compositions, and methods thereof.
Jean-Cosme Dodart, Yuanjing Liu, Chandra Vargeese, Zhong Zhong, Naoki Iwamoto, Jason Jingxin Zhang, Pachamuthu Kandasamy, Sethumadhavan Divakaramenon, Genliang Lu, Subramanian Marappan
Filed: 6 Aug 18
Utility
Chiral design
26 Oct 20
The present invention relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same.
Meena, David Butler, Naoki Iwamoto, Nenad Svrzikapa, Gregory L. Verdine, Ivan Zlatev
Filed: 21 Aug 18
Utility
Oligonucleotide Compositions and Methods Thereof
23 Sep 20
Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof.
Maria David Frank-Kamenetsky, Hailin Yang, Aaron Jay Morris, Chandra Vargeese, Christopher J. Francis
Filed: 3 Feb 20
Utility
Oligonucleotide compositions and methods thereof
27 Jul 20
Among other things, the present disclosure relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same.
Chandra Vargeese, Meena, Nenad Svrzikapa, Susovan Mohapatra, Christopher J. Francis, Gregory L. Verdine, Anna Sokolovska
Filed: 2 May 17
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