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Wave Life Sciences (WVE)

Utility
Compositions and methods for phosphoramidite and oligonucleotide synthesis
9 Aug 22
The present disclosure, among other things, provides technologies for preparing and purifying phosphoramidites for oligonucleotide synthesis.
David Charles Donnell Butler, Subramanian Marappan, Ik-Hyeon Paik
Filed: 13 Mar 17
Utility
Asymmetric auxiliary group
5 Oct 21
Mamoru Shimizu, Takeshi Wada
Filed: 19 May 20
Utility
Oligonucleotides, compositions and methods thereof
25 May 21
The present disclosure pertains to the recognition that immune responses mediated by CpG oligonucleotides can be affected by the stereochemistry of modified internucleotidic linkages such as phosphorothioates.
Jason Jingxin Zhang, Naoki Iwamoto, Christopher J. Francis, Chandra Vargeese, David Charles Donnell Butler, Sethumadhavan Divakaramenon, Genliang Lu, Subramanian Marappan
Filed: 2 Jun 17
Utility
Chiral design
26 Oct 20
The present invention relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same.
Meena, David Butler, Naoki Iwamoto, Nenad Svrzikapa, Gregory L. Verdine, Ivan Zlatev
Filed: 21 Aug 18
Utility
Oligonucleotide compositions and methods thereof
27 Jul 20
Among other things, the present disclosure relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same.
Chandra Vargeese, Meena, Nenad Svrzikapa, Susovan Mohapatra, Christopher J. Francis, Gregory L. Verdine, Anna Sokolovska
Filed: 2 May 17
Utility
Asymmetric auxiliary group
29 Jun 20
Mamoru Shimizu, Takeshi Wada
Filed: 5 Nov 18
Utility
Chiral control
16 Mar 20
The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same.
David Charles Donnell Butler, Naoki Iwamoto, Meena, Nenad Svrzikapa, Gregory L. Verdine, Ivan Zlatev
Filed: 16 Mar 17
Utility
Oligonucleotide compositions and methods thereof
18 Nov 19
Among other things, the present disclosure relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same.
Chandra Vargeese, Meena, Nenad Svrzikapa, Susovan Mohapatra, Christopher J. Francis, Gregory L. Verdine, Anna Sokolovska
Filed: 21 Jul 16
Utility
Oligonucleotide compositions and methods thereof
21 Oct 19
Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof.
David Charles Donnell Butler, Sethumadhavan Divakaramenon, Christopher J. Francis, Maria David Frank-Kamenetsky, Naoki Iwamoto, Genliang Lu, Subramanian Marappan, Meena, Chandra Vargeese, Gregory L. Verdine, Hailin Yang, Jason Jingxin Zhang
Filed: 22 Sep 18
Utility
Chiral auxiliaries
30 Sep 19
Takeshi Wada, Mamoru Shimizu
Filed: 21 Sep 11
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