41 patents
Utility
Compositions and methods for the treatment of fat infiltration in muscle
5 Dec 23
This disclosure provides methods of using compositions comprising amino acid entities to reduce fat infiltration in muscle, particularly under conditions of muscle atrophy.
Manu Chakravarthy, William Comb, Michael Hamill, Anthony Tramontin
Filed: 2 Mar 21
Utility
Compositions and Methods for the Treatment of Liver Diseases and Disorders
6 Apr 23
This disclosure provides combinations and methods for improving liver function, e.g., in a subject having a liver disease or disorder, or treating or preventing a liver disease or disorder, e.g., with hyperammonemia or muscle wasting in a subject.
Nadine Daou, William Comb, Alison Williams, Svetlana Marukian, Michael Hamill, Raffi Afeyan, Sean Carroll, Anthony Tramontin, Manu Chakravarthy
Filed: 23 Dec 20
Utility
Amino acid compositions and their use for the treatment of traumatic brain injury
4 Apr 23
This disclosure provides pharmaceutical compositions comprising defined amino acid components, and methods for treating traumatic brain injury comprising administering an effective amount of the compositions to a subject in need thereof.
Sean Carroll, Raffi Afeyan, Gianluca De Rienzo, Matthew Russell
Filed: 27 Apr 18
Utility
Amino Acid Compositions and Methods for Muscle and Myotube Modulation
23 Mar 23
This disclosure provides compositions comprising amino acid entities.
William Comb, Murat Cokol, Tripti Kulkarni
Filed: 5 Mar 21
Utility
Amino acid compositions and methods for the treatment of liver diseases
14 Mar 23
This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof.
Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt
Filed: 1 Jul 20
Utility
Amino Acid Compositions and Methods for the Treatment of Post-acute Sequelae of COVID-19
9 Feb 23
This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof.
Revati Wani, Alison Schecter, Michael Hamill, Margaret Koziel, Matthew Russell, Karim Azer, Karen Lavery, Joel Pradines
Filed: 25 Jul 22
Utility
Compositions and Methods Involving Amino Acids for the Treatment of Fat Infiltrations In Muscle
9 Feb 23
This disclosure provides methods of using compositions comprising amino acid entities to reduce fat infiltration in muscle, particularly under conditions of muscle dysfunction.
Manu Chakravarthy, William Comb
Filed: 23 Dec 20
Utility
Compositions and methods for the treatment of liver diseases and disorders associated with one or both of hyperammonemia or muscle wasting
7 Feb 23
This disclosure provides compositions and methods for treating or preventing liver diseases and disorders with hyperammonemia or muscle wasting in a subject.
William Comb, Sean Carroll, Raffi Afeyan, Michael Hamill
Filed: 15 Apr 20
Utility
Compositions and Methods Excluding or with Reduced Glutamine for the Treatment of Hemoglobinopathies and Thalassemias
5 Jan 23
This disclosure provides compositions and methods for improving erythrocyte dysfunction or treating a hemoglobinopathy or a thalassemia (e.g., sickle cell disease or β-thalassemia).
Revati Wani, Sean Carroll, Matthew Russell, Raffi Afeyan
Filed: 4 Dec 20
Utility
Compositions for Therapy and Health Containing Amino Acids with Bitter Taste
10 Nov 22
This disclosure provides a dry powder formulation of free amino acids with an acceptable and even good taste profile.
Thomas Hanlon, Andrew M. Wood
Filed: 16 Dec 21
Utility
Compositions and Formulations and Methods of Production and Use Thereof
3 Nov 22
Nutritive polypeptides are provided herein.
Alison Williams, Nathaniel W. Silver, Andrew Downey, David V. Erbe, Michael J. Hamill, David Arthur Berry
Filed: 2 Dec 21
Utility
Nutritive polypeptides and formulations thereof, and methods of production and use thereof
14 Jun 22
Nutritive polypeptides are provided herein.
Michael Hamill, Brett Boghigian, Caitlyn Harvey, David Berry, David Young, Geoffrey Von Maltzahn, John Kramarczyk, Jameson Rogers, Kathryn Heard, Michael Doherty, Nathaniel Silver, Phillip Samayoa, Subhayu Basu, Shaila Rahman, Vimal Vaidya, Ying-Ja Chen
Filed: 16 Mar 20
Utility
Amino acid compositions and methods for the treatment of liver diseases
28 Sep 21
This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof.
Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt, David Berry
Filed: 19 Dec 17
Utility
Compositions and Methods for the Treatment of Fat Infiltration In Muscle
23 Sep 21
This disclosure provides methods of using compositions comprising amino acid entities to reduce fat infiltration in muscle, particularly under conditions of muscle atrophy.
Manu Chakravarthy, William Comb, Michael Hamill, Anthony Tramontin
Filed: 2 Mar 21
Utility
Compositions and Methods for the Treatment of Hemoglobinopathies and Thalassemias
23 Sep 21
This disclosure provides compositions and methods for improving erythrocyte dysfunction or treating a hemoglobinopathy or a thalassemia (e.g., sickle cell disease or β-thalassemia).
Sean Carroll, Matthew Russell, Raffi Afeyan
Filed: 8 Jun 21
Utility
Compositions and Methods for the Reduction or Treatment of Insulin Resistance and Metabolic Conditions
9 Sep 21
This disclosure provides compositions and methods for reducing or treating insulin resistance in a subject.
Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt, William Comb, Nadine Daou, Svetlana Marukian
Filed: 19 Jun 19
Utility
Compositions and Methods for the Reduction or Treatment of Fibrosis
9 Sep 21
This disclosure provides compositions and methods for reducing or treating fibrosis, e.g., in a subject having a fibrotic condition or disorder.
Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt, Luke S. Hamm, Svetlana Marukian, Nadine Daou
Filed: 19 Jun 19
Utility
Compositions and Methods for the Reduction or Treatment of Inflammation
26 Aug 21
This disclosure provides compositions and methods for reducing or treating inflammation, e.g., in a subject having an inflammatory condition or disorder.
Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt, Simon Aoyama, Svetlana Marukian, Nadine Daou
Filed: 19 Jun 19
Utility
Amino acid compositions and methods for the treatment of liver diseases
24 Aug 21
This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof.
Michael Hamill, Raffi Afeyan, Chung-Wei Lee, Harry Luithardt, David Berry
Filed: 19 Dec 17
Utility
Compositions and methods for the treatment of hemoglobinopathies and thalassemias
13 Jul 21
This disclosure provides compositions and methods for improving erythrocyte dysfunction or treating a hemoglobinopathy or a thalassemia (e.g., sickle cell disease or β-thalassemia).
Sean Carroll, Matthew Russell, Raffi Afeyan
Filed: 19 Jun 19