5 patents
Utility
Gene Therapy Compositions and Methods for Treating Parkinson's Disease
9 Jun 22
A method of improving motor function and reducing dyskinesia in a subject suffering from a neurodegenerative disease or a disease where endogenous dopamine levels are reduced in the subject comprising administering an effective amount of a viral vector comprising a nucleic acid construct comprising (i) a nucleotide sequence which encodes tyrosine hydroxylase (TH), (ii) a nucleotide sequence which encodes GTP-cyclohydrolase I (CH1), (iii) a nucleotide sequence which encodes Aromatic Amino Acid Dopa Decarboxylase (AADC), or any combination thereof to the subject.
Gavin CORCORAN, Michele STONE, Kyriacos MITROPHANOUS, Hannah STEWART
Filed: 10 Mar 20
Utility
Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT
19 Apr 22
The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor and their uses for the treatment and prophylaxis of visual hallucinations associated with Lewy Body dementia.
Lawrence Tim Friedhoff, Shankar Ramaswamy, Yandong Wen
Filed: 20 Nov 20
Utility
Diaryl and Arylheteroaryl Urea Derivatives As Modulators of the 5-HT2A Serotonin Receptor Useful for the Prophylaxis and Treatment of Hallucinations Associated with a Neurodegenerative Disease
17 Jun 21
The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor and their uses for the treatment and prophylaxis of visual hallucinations associated with Lewy Body dementia.
Lawrence Tim FRIEDHOFF, Shankar RAMASWAMY, Yandong WEN
Filed: 20 Nov 20
Utility
Use of 5HT2A Inverse Agonists for Treating Psychosis
6 May 21
Disclosed herein are methods of using a 5-HT2A serotonin receptor inverse agonist for the prophylaxis and/or treatment of psychosis or psychotic symptoms in an individual comprising administering to said individual in need thereof a therapeutically effective amount of said 5-HT2A serotonin receptor inverse agonist.
Lawrence Tim FRIEDHOFF, Brante Patrick SAMPEY
Filed: 20 Aug 20
Utility
Diaryl and Arylheteroaryl Urea Derivatives As Modulators of the 5-HT2A Serotonin Receptor Useful for the Prophylaxis and Treatment of Rem Sleep Behavior Disorder
23 Dec 20
The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor and their uses for the treatment of REM sleep behavior disorder.
Lawrence Tim FRIEDHOFF, Shankar RAMASWAMY, Yandong WEN
Filed: 27 Jan 20
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