17 patents
Utility
Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs
5 Dec 23
Methods of using glucokinase (GK) activators are generally disclosed herein, particularly in combination with insulin or insulin analogs.
Jennifer L. R. Freeman, Maria Carmen Valcarce Lopez
Filed: 18 Feb 21
Utility
Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof
16 May 23
Substituted fused imidazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted fused imidazole derivative, and methods of use in treating renal diseases are provided.
Adnan M. M. Mjalli, Dharma Rao Polisetti, Jareer Nabeel Kassis, Matthew J. Kostura, Mustafa Guzel, Otis Clinton Attucks, Robert Carl Andrews, Samuel Victory, Suparna Gupta
Filed: 11 Aug 21
Utility
Metabolites of [3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4 yl}-phenoxy)-propyl]-diethyl-amine
13 Dec 22
The present invention relates to metabolites of [3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine.
William Kenneth Banner, Bapu Gaddam, Dharma Rao Polisetti, Robert Carl Andrews, Samuel Victory
Filed: 25 Mar 21
Utility
Phenoxy acetic acids and phenyl propionic acids as PPAR delta agonists
23 Aug 22
Phenoxy acetic acids and phenyl propionic acids and their use in improving mitochondrial energy output in a subject are provided herein.
Per Sauerberg, Pavel Pihera, Zdenek Polivka, Miroslav Havranek, Ingrid Pettersson, John Patrick Mogensen
Filed: 9 Mar 21
Utility
Crystalline forms of [3-(4- {2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4-yl} -phenoxy)-propyl]-diethyl-amine
23 Aug 22
The present invention relates to crystalline forms of [3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethylamine (“COMPOUND I”) useful in the treatment of RAGE mediated diseases.
Zheqiong Wu
Filed: 14 Sep 20
Utility
Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof
28 Sep 21
Substituted fused imidazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted fused imidazole derivative, and methods of use in treating renal diseases are provided.
Adnan M. M. Mjalli, Dharma Rao Polisetti, Jareer Nabeel Kassis, Matthew J. Kostura, Mustafa Guzel, Otis Clinton Attucks, Robert Carl Andrews, Samuel Victory, Suparna Gupta
Filed: 22 Sep 20
Utility
Use of a PPAR-δ agonist for reducing loss of muscle strength, muscle mass, or type I muscle fibers in an immobilized limb
24 Aug 21
The present invention provides methods for reducing loss of muscle strength, muscle mass, or Type I muscle fibers in an immobilized limb by administering (E)-[4-[3-(4-Fluorophenyl)-3-[4-[3-(morpholin-4-yl)propynyl]phenyl]allyloxy]-2-methyl-phenoxy]acetic acid or a pharmaceutically acceptable salt thereof.
Maria Carmen Valcarce Lopez, Eliot Ohlstein
Filed: 22 Oct 19
Utility
Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs
23 Mar 21
Methods of using glucokinase (GK) activators are generally disclosed herein, particularly in combination with insulin or insulin analogs.
Jennifer L. R. Freeman, Maria Carmen Valcarce Lopez
Filed: 13 Jan 20
Utility
Phenoxy acetic acids and phenyl propionic acids as PPAR delta agonists
16 Mar 21
Phenoxy acetic acids and phenyl propionic acids and their use in improving mitochondrial energy output in a subject are provided herein.
Per Sauerberg, Pavel Pihera, Zdenek Polivka, Miroslav Havranek, Ingrid Petterson, John Patrick Mogensen
Filed: 8 Nov 19
Utility
Bach1 inhibitors in combination with Nrf2 activators and pharmaceutical compositions thereof
26 Jan 21
The disclosure provides pharmaceutical compositions comprising Bach1 Inhibitors and Nrf2 Activators.
Otis Clinton Attucks
Filed: 25 Sep 19
Utility
Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof
12 Jan 21
Substituted fused imidazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted fused imidazole derivative, and methods of use in treating non-alcoholic steatohepatitis are provided.
Adnan M. M. Mjalli, Dharma Rao Polisetti, Jareer Nabeel Kassis, Matthew J. Kostura, Mustafa Guzel, Otis Clinton Attucks, Robert Carl Andrews, Samuel Victory, Suparna Gupta
Filed: 10 Jan 20
Utility
Glucokinase activator compositions for the treatment of diabetes
16 Mar 20
The present invention relates to the use of liver-selective glucokinase activators and a GLP1 analog in restoring insulin sensitivity and treating type II diabetes, including reducing body weight in subjects undergoing type II diabetes treatment.
Maria Carmen Valcarce Lopez, Tung Fong
Filed: 17 May 18
Utility
Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors
24 Feb 20
The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-α or by PDE4 including, but not limited to, allergic rhinitis.
Adnan M. M. Mjalli, Bapu Gaddam, Dharma Rao Polisetti, Matthew J. Kostura, Mustafa Guzel
Filed: 9 Jul 19
Utility
Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof
24 Feb 20
Substituted fused imidazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted fused imidazole derivative, and methods of use in treating conditions or diseases of the eye are provided.
Adnan M. M. Mjalli, Dharma Rao Polisetti, Jareer Nabeel Kassis, Matthew J. Kostura, Mustafa Guzel, Otis Clinton Attucks, Robert Carl Andrews, Samuel Victory, Suparna Gupta
Filed: 4 Mar 19
Utility
Phenoxy acetic acids and phenyl propionic acids as PPAR delta agonists
11 Nov 19
Phenoxy acetic acids and phenyl propionic acids and their use in improving mitochondrial energy output in a subject are provided herein.
Per Sauerberg, Pavel Pihera, Zdenek Polivka, Miroslav Havranek, Ingrid Pettersson, John Patrick Mogensen
Filed: 19 Nov 17
Utility
Bach1 inhibitors in combination with Nrf2 activators and pharmaceutical compositions thereof
4 Nov 19
The disclosure provides pharmaceutical compositions comprising Bach1 Inhibitors and Nrf2 Activators.
Otis Clinton Attucks
Filed: 12 Nov 18
Utility
Use of a PPAR-δ agonist for reducing loss of muscle strength, muscle mass, or type I muscle fibers in an immobilized limb
28 Oct 19
The present invention provides methods for reducing loss of muscle strength, muscle mass, or Type I muscle fibers in an immobilized limb by administering (E)-[4-[3-(4-Fluorophenyl)-3-[4-[3-(morpholin-4-yl)propynyl]phenyl]allyloxy]-2-methyl-phenoxy]acetic acid or a pharmaceutically acceptable salt thereof.
Maria Carmen Valcarce Lopez, Eliot Ohlstein
Filed: 10 Apr 18
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