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NVCR NovoCure

GRANT
Utility
Methods and compositions for treating tumors with TTFields and sorafenib
23 Nov 21
Viability of cancer cells (e.g., hepatocellular carcinoma cells) can be reduced by administering sorafenib to the cancer cells and applying an alternating electric field with a frequency between 100 and 400 kHz to the cancer cells.
Karnit Gotlib, Einav Zeevi, Rosa S. Schnaiderman, Tali Voloshin-Sela, Moshe Giladi, Adrian Kinzel, Eilon Kirson, Uri Weinberg, Yoram Palti, Shiri Davidi
Filed: 9 Jul 19
APP
Utility
Conductive Pad Generating Tumor Treating Field and Methods of Production and Use Thereof
11 Nov 21
A conductive pad having a topcoat layer, an electrode element and a conductive gel element is described.
Richard Deslauriers
Filed: 6 May 21
APP
Utility
Compositions and Methods of Applying Alternating Electric Fields to Pluripotent Stem Cells
11 Nov 21
Disclosed are methods and compositions for preventing or disrupting mitosis of pluripotent stem cells, killing pluripotent stem cells, preventing or disrupting division of pluripotent stem cells, reducing the viability of pluripotent stem cells, slowing the progression or differentiation of pluripotent stem cells, and treating an ectopic pregnancy.
Tali Voloshin-Sela
Filed: 7 May 21
APP
Utility
Temperature Measurement in Arrays for Delivering TTFields
11 Nov 21
TTFields therapy is a proven approach for treating tumors using electric fields.
Yoram WASSERMAN, Michael KRINITSKY, Mikhail SHTOTLAND, Victor KAIKOV
Filed: 21 Jul 21
GRANT
Design
Display screen or portion thereof with a graphical user interface
2 Nov 21
Hadas Sara Hershkovich, Zeev Bomzon, Gil Zigelman, Shira Luk-Zilberman, Ori Kook, Oren Bakalo
Filed: 3 May 19
GRANT
Utility
Delivering tumor treating fields (TTFields) to the infratentorial brain
2 Nov 21
This application discloses an improved approach for delivering Tumor Treating Fields (TTFields) at a therapeutically effective strength to the infratentorial regions of the brain.
Ariel Naveh, Shay Levi, Zeev Bomzon, Eilon Kirson
Filed: 4 Sep 18
APP
Utility
Using Alternating Electric Fields to Increase Permeability of the Blood Brain Barrier
28 Oct 21
Many drugs and other molecules cannot ordinarily traverse the blood brain barrier (BBB).
Carsten HAGEMANN, Mario LOHR, Almuth F. KESSLER, Malgorzata BUREK, Carola FORSTER, Catherine BRAMI, Hadas Sara HERSHKOVICH, Tali VOLOSHIN-SELA
Filed: 21 Apr 21
GRANT
Utility
Generating tumor treating fields (TTFields) with high uniformity throughout the brain
26 Oct 21
This application discloses configurations for arranging transducer arrays on a person's head to impose tumor treating fields (TTFields) in the brain at field strengths that are as uniform as possible throughout the entire brain.
Zeev Bomzon, Ariel Naveh, Ofir Yesharim
Filed: 11 Oct 19
APP
Utility
Treating Autoimmune Diseases Using an Alternating Electric Field to Reduce the Proliferation of T-Cells
7 Oct 21
Damage from autoimmune diseases can be prevented or minimized by positioning a plurality of electrodes in or on a subject's body, and applying an AC voltage between the plurality of electrodes so as to impose an alternating electric field through the tissue that is being attacked by the autoimmune disease and/or draining lymph nodes associated with that tissue.
Yaniv ALON, Tali VOLOSHIN-SELA, Moshe GILADI
Filed: 28 May 21
APP
Utility
Intravenous / Intra-Spinal / Intra-Cavity / Intraventricular Delivery of TTFields (Tumor Treating Fields) for Treating Cancer and Metastases
30 Sep 21
Tumor treating fields (TTFields) may be applied to a person's body using six different types of electrodes.
Richard DESLAURIERS, William DOYLE
Filed: 26 Mar 21
GRANT
Utility
Treating patients with TTFields with the electrode positions optimized using deformable templates
7 Sep 21
Embodiments receive images of a body area of a patient; identify abnormal tissue in the image; generate a data set with the abnormal tissue masked out; deform a model template in space so that features in the deformed model template line up with corresponding features in the data set; place data representing the abnormal tissue back into the deformed model template; generate a model of electrical properties of tissues in the body area based on the deformed and modified model template; and determine an electrode placement layout that maximizes field strength in the abnormal tissue by using the model of electrical properties to simulate electromagnetic field distributions in the body area caused by simulated electrodes placed respective to the body area.
Noa Urman, Zeev Bomzon
Filed: 13 Dec 17
GRANT
Utility
Using alternating electric fields to increase cell membrane permeability
31 Aug 21
Certain substances (e.g., large molecules) that ordinarily cannot traverse the cell membrane of cells can be introduced into cells by applying an alternating electric field to the cell for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the cell membrane.
Edwin Chang, Chirag B. Patel, Sanjiv S. Gambhir, Tali Voloshin-Sela, Yaara Porat, Moshe Giladi
Filed: 1 May 20
GRANT
Utility
Temperature measurement in arrays for delivering TTFields
24 Aug 21
TTFields therapy is a proven approach for treating tumors using electric fields.
Yoram Wasserman, Michael Krinitsky, Mikhail Shtotland, Victor Kaikov
Filed: 11 Aug 17
APP
Utility
Assemblies Containing Two Conductive Gel Compositions and Methods of Production and Use Thereof
22 Jul 21
An assembly for use in a TTField-generating system is disclosed that includes at least one electrode in combination with a polymerized conductive hydrogel and a liquid conductive hydrogel disposed on at least a portion of the polymerized hydrogel.
Richard Deslauriers
Filed: 22 Jan 21
APP
Utility
Arrays for Delivering Tumor Treating Fields (TTFields) with Individually Accessible Electrode Elements and Temperature Sensors
1 Jul 21
Tumor treating fields (TTFields) can be delivered to a subject's body at higher field strengths by switching off one or more electrode elements in a transducer array that are overheating.
Yoram WASSERMAN
Filed: 21 Dec 20
APP
Utility
Methods, Systems, and Apparatuses for Associating Dielectric Properties with a Patient Model
1 Jul 21
Methods, systems, and apparatuses are described for associating dielectric properties with a patient model.
Reuven Ruby Shamir, Zeev Bomzon, Noa Urman
Filed: 29 Dec 20
APP
Utility
High Voltage, High Efficiency Sine Wave Generator That Prevents Spikes During Amplitude Adjustments and Switching of Channels
1 Jul 21
This application describes a variety of approaches for generating high voltage sinusoidal signals whose output voltage can be adjusted rapidly, without introducing high-frequency artifacts on the output.
Yoram WASSERMAN
Filed: 17 Dec 20
APP
Utility
Methods, Systems, and Apparatuses for Fast Approximation of Electric Field Distribution
1 Jul 21
Methods, systems, and apparatuses are described for fast approximation of electric field distribution.
Reuven Ruby Shamir, Zeev Bomzon
Filed: 31 Dec 20
APP
Utility
Methods, Systems, and Apparatuses for Managing Temperatures Induced by Alternating Fields
1 Jul 21
Methods, systems, and apparatuses are described for managing temperatures induces my alternating electric fields by selectively activating/deactivating electrodes of a pair of transducer arrays according to defined parameters.
Kristen W. Carlson, Zeev Bomzon
Filed: 10 Dec 20
APP
Utility
Methods, Systems, and Apparatuses for Image Segmentation
1 Jul 21
Methods, systems, and apparatuses are described for interacting with images, segmenting the images, and determining one or more regions of interest within the images.
Zeev Bomzon
Filed: 31 Dec 20
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