195 patents
Page 6 of 10
Utility
Methods and Apparatuses for Visualization of Tumor Segmentation
8 Sep 22
A computer-implemented method for tumor segmentation, the method comprises obtaining image data of a region of interest of a subject's body, wherein the region of interest corresponds to a tumor of the subject's body, generating two or more tumor segmentation predictions based on the image data, calculating a divergence between the two or more tumor segmentation predictions, and generating a visualization of tumor segmentation uncertainty based on the calculated divergence between the two or more tumor segmentation predictions.
Michal HOLTZMAN GAZIT, Reuven Ruby SHAMIR
Filed: 1 Mar 22
Utility
Using Alternating Electric Fields to Increase Permeability of the Blood Brain Barrier
25 Aug 22
Certain substances (e.g., large molecules) that ordinarily cannot traverse the blood brain barrier can be introduced into the brain by applying an alternating electric field to the brain for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the blood brain barrier.
Carsten HAGEMANN, Mario LOHR, Almuth F. KESSLER, Malgorzata BUREK, Carola FORSTER, Catherine BRAMI, Hadas Sara HERSHKOVICH, Tali VOLOSHIN-SELA
Filed: 11 May 22
Utility
Methods and Compositions for Determining Susceptibility to Treatment with Checkpoint Inhibitors
25 Aug 22
Methods and kits treating a subject with a checkpoint inhibitor are provided by detecting expression levels of one or more biomarkers (e.g., cytokines and cytotoxic genes, immune cell functional regulators, naïve immune cell markers, regulatory T cell factors, and immune inhibitory receptors) in immune cells of a patient or subject with a condition (e.g., cancer) before and after exposure of tumor cells to alternating electric fields.
David TRAN, Dongjiang Chen
Filed: 16 Feb 22
Utility
Arrays for Delivering Tumor Treating Fields (TTFields) with Sets of Electrode Elements Having Individually Adjustable Active Areas
18 Aug 22
Tumor treating fields (TTFields) can be delivered to a subject's body using electrode elements that are arranged in sets, wherein each set includes a respective first electrode element and a respective second electrode element disposed in thermal contact with each other.
Yoram WASSERMAN
Filed: 14 Feb 22
Design
Electrode array
16 Aug 22
Eilon Kirson, Yoram Wasserman, Noa Halavee
Filed: 27 Nov 19
Utility
Evaluating Quality of Segmentation of an Image into Different Types of Tissue for Planning Treatment Using Tumor Treating Fields (TTFields)
11 Aug 22
To plan tumor treating fields (TTFields) therapy, a model of a patient's head is often used to determine where to position the transducer arrays during treatment, and the accuracy of this model depends in large part on an accurate segmentation of MRI images.
Reuven R. SHAMIR, Zeev BOMZON, Mor VARDI
Filed: 9 Feb 22
Design
Electrode array
9 Aug 22
Yoram Wasserman
Filed: 3 Jan 20
Utility
Varying Parameters of Tumor Treating Fields (TTFields) Treatment to Overcome Treatment Resistance
4 Aug 22
Treatment resistance to Tumor Treating Fields (TTFields) has been observed in some subjects after those subjects were treated with TTFields for extended periods of time.
Reuven R. SHAMIR
Filed: 1 Feb 22
Design
Electrode array
2 Aug 22
Eilon Kirson, Yoram Wasserman, Noa Halavee
Filed: 27 Nov 19
Utility
Using alternating electric fields to increase permeability of the blood brain barrier
2 Aug 22
Certain substances (e.g., large molecules) that ordinarily cannot traverse the blood brain barrier can be introduced into the brain by applying an alternating electric field to the brain for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the blood brain barrier.
Carsten Hagemann, Mario Lohr, Almuth F. Kessler, Malgorzata Burek, Carola Forster, Catherine Brami, Hadas Sara Hershkovich, Tali Voloshin-Sela
Filed: 22 Aug 19
Utility
Methods, Systems, and Apparatuses for Medical Image Enhancement to Optimize Transducer Array Placement
28 Jul 22
A computer-implemented method to generate a three-dimensional model, wherein the computer comprises one or more processors and memory accessible by the one or more processors, and the memory stores instructions that when executed by the one or more processors cause the computer to perform the computer-implemented method, includes: receiving first image data of a first portion of the patient's body in a first image modality, receiving second image data of a second portion of the patient's body in a second image modality, modifying the second image data from the second image modality to the first image modality, and generating, based on the first image data in the first image modality and the modified second image data in the second image modality, a three-dimensional model of the first portion and the second portion of the patient's body.
Reuven Ruby SHAMIR, Noa URMAN, Yana GLOZMAN
Filed: 18 Jan 22
Utility
Arrays for delivering tumor treating fields (TTFields) with selectively addressable sub-elements
26 Jul 22
Tumor treating fields (TTFields) can be delivered to a subject's body at higher field strengths by switching off one or more electrode elements that are overheating without switching off other electrode elements that are not overheating.
Yoram Wasserman, Michael Krinitsky, Sergey Kirilov, Michael Shtotland, Victor Kaikov
Filed: 18 Nov 19
Utility
Methods And Compositions For Using Alternating Electric Fields In Gene Therapy
30 Jun 22
Disclosed are compositions for methods of transporting of a vector, therapeutic, detectable, or combination thereof across a cell membrane of a cell.
Tali Voloshin-Sela, Lilach Avigdor, Yaara Porat, Helena Mumblat
Filed: 22 Dec 21
Utility
Method and Apparatus for Determining Transducer Locations to Generate Tumor Treating Fields
30 Jun 22
A computer-implemented method of determining locations of transducers on a subject's body for applying tumor treating fields, the method including: selecting a plurality of pairs of locations on the subject's body, each pair of locations having a first location to locate a first transducer and a second location to locate a second transducer; obtaining, for each pair of locations, a voltage measurement and a current measurement for an electric field induced between the first transducer and the second transducer, the induced electric field passing through a tumor of the subject's body; calculating, for each pair of locations, a resistivity based on the voltage measurement and the current measurement; and selecting and outputting one or more recommended pairs of locations based on the calculated resistivities.
Tal MARCIANO
Filed: 17 Dec 21
Utility
Amplitude Modulation for Tumor Treating Fields
30 Jun 22
A method of applying tumor treating fields to a subject's body includes: inducing a modulated electric field between a first transducer and a second transducer to treat a tumor of the subject's body, wherein the first transducer is located at a first location of the subject's body, and wherein the second transducer is located at a second location of the subject's body.
Kristen W. CARLSON
Filed: 29 Dec 21
Utility
Pyroelectric-Based Temperature Sensing of Transducer Arrays for Applying Tumor Treating Fields (TTFields)
23 Jun 22
TTFields are applied using transducer arrays made from a plurality of individual electrode elements.
Yoram WASSERMAN, Stas OBUCHOVSKY, Nataliya KUPLENNIK
Filed: 14 Dec 21
Utility
Optimization of Composite Electrode
23 Jun 22
Apparatus and methods for imposing electric fields through a target region in a body of a patient are described.
Yoram WASSERMAN
Filed: 14 Dec 21
Utility
Uploading Data from an Isolated System without Compromising Isolation
16 Jun 22
A data transfer apparatus (“DTA”) connects to the field generator in a TTFields therapy system using the same connector on the field generator that is used to connect a transducer interface to the field generator.
Yoram WASSERMAN, Golan BAR-TAL, Michael VARSHAVER, Shimon ELKABETZ
Filed: 4 Mar 22
Utility
Using alternating electric fields to increase permeability of the blood brain barrier
7 Jun 22
Certain substances (e.g., large molecules) that ordinarily cannot traverse the blood brain barrier can be introduced into the brain by applying an alternating electric field to the brain for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the blood brain barrier.
Carsten Hagemann, Mario Lohr, Almuth F. Kessler, Malgorzata Burek, Carola Forster, Catherine Brami, Hadas Sara Hershkovich, Tali Voloshin-Sela
Filed: 22 Aug 19
Utility
Increasing the Efficacy of Tumor Treating Fields (TTFields) by Applying the TTFields at Peak Intensity Less Than Half the Time
26 May 22
An alternating electric field may be applied to a target region in a living body or to cells in vitro.
Moshe GILADI, Eyal DOR-ON, Einav ZEEVI, Rotem ENGELMAN
Filed: 23 Nov 21