195 patents
Page 7 of 10
Utility
Methods and Apparatuses for Determining Transducer Locations to Generate Tumor Treating Fields
12 May 22
A computer-implemented method to determine placement of transducers on a subject's body, the method including: selecting a plurality of intersecting line segment pairs on an image of the subject's body, each of the line segment pairs intersecting in a region of the image corresponding to a tumor in the subject's body, each of the line segment pairs corresponding to locations to place the transducers on the subject's body; determining a pair value for each of the intersecting line segment pairs, each pair value based on a length of each line segment of the corresponding intersecting line segment pair; selecting one or more intersecting line segment pairs based on the pair values to obtain one or more selected intersecting line segment pairs; and outputting the locations to place the transducers on the subject's body corresponding to the one or more selected intersecting line segment pairs.
Tal MARCIANO, Oshrit Zeevi
Filed: 2 Nov 21
Utility
Generating Tumor Treating Fields (TTFields) with High Uniformity throughout the Brain
21 Apr 22
This application discloses configurations for arranging transducer arrays on a person's head to impose tumor treating fields (TTFields) in the brain at field strengths that are as uniform as possible throughout the entire brain.
Zeev BOMZON, Ariel NAVEH, Ofir YESHARIM
Filed: 28 Dec 21
Utility
Uploading data from an isolated system without compromising isolation
5 Apr 22
A data transfer apparatus (“DTA”) connects to the field generator in a TTFields therapy system using the same connector on the field generator that is used to connect a transducer interface to the field generator.
Yoram Wasserman, Golan Bar-Tal, Michael Varshaver, Shimon Elkabetz
Filed: 13 Apr 20
Utility
Varying the Metallization Area on Individual Electrode Elements in a Tumor Treating Fields (TTFields) System to Maximize Current without Overheating
31 Mar 22
Conventional transducer arrays for applying tumor treating fields (TTFields) include a set of individual electrode elements, and the more peripherally-located electrode elements (e.g., electrode elements at the corners or edges of the transducer arrays) tend to get hotter than the more centrally located electrode elements.
Yoram WASSERMAN
Filed: 17 Sep 21
Utility
Enhanced-Flexibility Transducer Arrays for Delivering TTFields (Tumor Treating Fields)
31 Mar 22
A transducer array for use in tumor-treating fields (TTFields) therapy is particularly suited for use in treating abdominal or thoracic cancers.
Eilon KIRSON, Yoram WASSERMAN, Noa HALAVEE
Filed: 8 Dec 21
Utility
Compositions And Methods For Increasing Cancer Cell Sensitivity To Alternating Electric Fields
31 Mar 22
Disclosed herein are methods for increasing sensitivity of a cancer cell to alternating electric fields by administering an AKT inhibitor, a mammalian target of rapamycin (mTOR) inhibitor, a Phosphatidylinositol 3-Kinase (PI3K) inhibitor, and/or a Glycogen synthase kinase 3β (GSK3β) inhibitor.
Tali Voloshin-Sela, Lilach Avigdor, Anat Klein-Goldberg
Filed: 3 Aug 21
Utility
Method and Apparatus for Delivering Tumor Treating Fields to a Torso, and Method for Determining Locations for Transducers to Deliver Tumor Treating Fields
31 Mar 22
A method of applying tumor treating fields to a torso of a subject's body, the method including: locating a first transducer at a first location of the subject's body, the first location being on the torso of the subject's body; locating a second transducer at a second location of the subject's body, the second location being below the torso of the subject's body; and inducing an electric field between at least part of the first transducer and at least part of the second transducer.
Ori Farber, Ariel Naveh, Yoram Wasserman
Filed: 28 Sep 21
Utility
Connector for Detachable Array
31 Mar 22
Apparatus and methods for imposing electric fields through a target region in a body of a patient are described.
Yoram Wasserman, Stas Obuchovsky, Nataliya Kuplennik
Filed: 30 Sep 21
Utility
Methods and Systems for Transducer Array Placement and Skin Surface Condition Avoidance
31 Mar 22
A method for applying tumor treating fields, the method comprising: determining, based on two-dimensional (2D) image data associated with a portion of a subject's body, one or more landmarks and one or more skin surface conditions; determining a representation of the one or more landmarks and the one or more skin surface conditions in three-dimensional (3D) space; determining, based on the representation of the one or more landmarks and the one or more skin surface conditions in 3D space, a plurality of placement positions for one or more transducer arrays on the subject's body for applying tumor treating fields; determining, based on the one or more skin surface conditions in 3D space, one or more recommended placement positions of the plurality of placement positions for the one or more transducer arrays; and outputting an indication of the one or more recommended placement positions for the one or more transducer arrays.
Oren Ben Zion BAKALO, Reuven Ruby SHAMIR
Filed: 28 Sep 21
Utility
Implantable Arrays For Providing Tumor Treating Fields
31 Mar 22
An implantable apparatus can be positioned in a body of a patient.
Kristen W. Carlson
Filed: 30 Sep 21
Utility
Methods And Compositions For Treating Coronavirus
24 Mar 22
Disclosed are methods of inhibiting a coronavirus from infecting or replicating in a cell comprising exposing the cell to an alternating electric field for a period of time, the alternating electric field having a frequency and field strength, wherein the frequency and field strength of the alternating electric field inhibits coronavirus infection or replication.
Tali Voloshin-Sela, Lilach Avigdor, Yaara Porat, Moshe Giladi, Helena Are Yaara, Helena Mumblat
Filed: 17 Sep 21
Utility
Evaluating quality of segmentation of an image into different types of tissue for planning treatment using tumor treating fields (TTFields)
15 Mar 22
To plan tumor treating fields (TTFields) therapy, a model of a patient's head is often used to determine where to position the transducer arrays during treatment, and the accuracy of this model depends in large part on an accurate segmentation of MRI images.
Reuven R. Shamir, Zeev Bomzon, Mor Vardi
Filed: 7 Jan 20
Utility
Generating tumor treating fields (TTFields) with high uniformity throughout the brain
8 Feb 22
This application discloses configurations for arranging transducer arrays on a person's head to impose tumor treating fields (TTFields) in the brain at field strengths that are as uniform as possible throughout the entire brain.
Zeev Bomzon, Ariel Naveh, Ofir Yesharim
Filed: 11 Oct 19
Utility
Enhanced-flexibility transducer arrays for delivering TTFields (tumor treating fields)
18 Jan 22
A transducer array for use in tumor-treating fields (TTFields) therapy is particularly suited for use in treating abdominal or thoracic cancers.
Eilon Kirson, Yoram Wasserman, Noa Halavee
Filed: 27 Nov 19
Utility
Flexible Transducer Arrays with a Polymer Insulating Layer for Applying Tumor Treating Fields (TTFields)
30 Dec 21
Described herein are devices for applying an alternating electric field to a living subject or an in vitro medium at a frequency between 100 kHz and 500 kHz.
Yoram Wasserman, Stas Obuchovsky, Nataliya Kuplennik
Filed: 29 Jun 21
Utility
Fabricating Organic Light Emitting Diodes (OLEDs) Using Tubulin
30 Dec 21
Organic light-emitting diodes are disclosed comprising an electron transport layer and a hole transport layer.
Aarat Pratyaksh KALRA, Jack Adam TUSZYNSKI, Sahil Deepak PATEL, Karthik SHANKAR
Filed: 22 Jun 21
Utility
TTF Generated Proliferation of Cytotoxic T Cells to Create a Specific Pro-Inflammatory Response
23 Dec 21
Disclosed are methods of increasing proliferation of CD8+ T cells comprising exposing a target site to an alternating electric field for a period of time, the alternating electric field having a frequency and field strength, wherein the frequency and field strength of the alternating electric field increases proliferation of CD8+ T cells at the target site.
Tali Voloshin-Sela, Lilach Avigdor
Filed: 18 Jun 21
Utility
Treating Autoinflammatory and Mitochondrial Diseases Using an Alternating Electric Field
9 Dec 21
Autoinflammatory and mitochondrial disorders can be treated by positioning a plurality of electrodes in or on a subject's body, and applying an AC voltage between the plurality of electrodes so as to impose an alternating electric field through the tissue that is being affected by the autoinflammatory or mitochondrial disease.
Stuart SMITH, Lilach AVIGDOR, Tali VOLOSHIN-SELA
Filed: 25 Jun 21
Utility
Reducing motility of cancer cells using tumor treating fields (TTFields)
7 Dec 21
The spreading of cancer cells in a target region can be inhibited by imposing a first AC electric field in the target region for a first interval of time, with a frequency and amplitude selected to disrupt mitosis of the cancer cells; and imposing a second AC electric field in the target region for a second interval of time, with a frequency and the amplitude selected to reduce motility of the cancer cells.
Moshe Giladi, Rosa S. Shnaiderman
Filed: 30 Sep 20
Utility
Implantable Arrays For Providing Tumor Treating Fields
2 Dec 21
An implantable apparatus can be positioned in a body of a patient.
Moshe Giladi, Uri Weinberg
Filed: 2 Jun 21