73 patents
Utility
Antigen Presenting Polypeptide Complexes and Methods of Use Thereof
28 Dec 23
The present disclosure provides Multimeric Antigen Presenting Polypeptides (MAPPs) for the presentation of KRAS antigens in the context of a class I MHC receptor.
Ronald D. SEIDEL, III, Rodolfo J. CHAPARRO, John F. ROSS, Chee Meng LOW, Saso CEMERSKI
Filed: 8 Nov 21
Utility
TGF-Beta Polypeptides
28 Dec 23
The present disclosure provides Transforming Growth Factor Beta (TGF-β) polypeptide constructs and complexes that find use in, for example, therapeutic treatment of diseases including autoimmune diseases and metabolic diseases and disorders.
Ronald D. SEIDEL, III, Rodolfo J. CHAPARRO, John F. ROSS, Chee Meng LOW, Anish SURI, Matteo Giacomo LEVISETTI
Filed: 22 Nov 21
Utility
TGF-Beta Polypeptides
28 Dec 23
The present disclosure provides T-cell modulatory multimeric polypeptides (T-Cell-MMP) and their epitope conjugates comprising at least one immunomodulatory polypeptide (“MOD”) that may be selected to exhibit reduced binding affinity to a cognate co-immunomodulatory polypeptide (“Co-MOD”).
Ronald D. SEIDEL, III, Rodolfo J. CHAPARRO, John F. ROSS, Chee Meng LOW
Filed: 12 Apr 23
Utility
T-cell Modulatory Multimeric Polypeptides and Methods of Use Thereof
14 Dec 23
The present disclosure provides variant immunomodulatory polypeptides, and fusion polypeptides comprising the variant immunomodulatory peptides.
Ronald D. Seidel, III, Rodolfo J. Chaparro
Filed: 26 May 23
Utility
Multimeric T-cell Modulatory Polypeptides and Methods of Use Thereof
7 Dec 23
The present disclosure provides T-cell modulatory multimeric polypeptides that comprise an immunomodulatory polypeptide and that comprise an epitope-presenting Wilms tumor peptide.
Saso Cemerski, Ronald D. Seidel, III, Rodolfo J. Chaparro, John F. Ross
Filed: 14 Jun 23
Utility
Methods for Modulating an Immune Response
23 Nov 23
The present disclosure provides methods of modulating an immune response in an individual.
Ronald D. Seidel, III, Rodolfo J. Chaparro
Filed: 27 Jul 23
Utility
MHC Class II T-cell Modulatory Multimeric Polypeptides for Treating Type 1 Diabetes Mellitus (T1D) and Methods of Use Thereof
2 Nov 23
The present disclosure provides T-cell modulatory multimeric polypeptides (TMMPs) comprising a type 1 diabetes (T1D)-associated peptide epitope, MHC class II polypeptides, and one or more immunomodulatory polypeptides.
Ronald D. Seidel, III, Rodolfo J. Chaparro, John F. Ross, Chee Meng Low
Filed: 6 Jul 23
Utility
T Cell Modulatory Polypeptides and Methods of Use Thereof
26 Oct 23
The present disclosure provides T cell modulatory polypeptides (TMPs) that comprise an immunomodulatory polypeptide, class I HLA polypeptides (a class I HLA heavy chain polypeptide and a β2 microglobulin polypeptide), and a Betacoronavirus (e.g., a SARS-CoV-2) peptide that presents an epitope to a T-cell receptor.
Anish Suri
Filed: 26 Aug 22
Utility
MHC Class II T-cell Modulatory Multimeric Polypeptides and Methods of Use Thereof
19 Oct 23
The present disclosure provides T-cell modulatory multimeric polypeptides (TMMPs) comprising an autoimmune dis-ease-associated-associated peptide epitope, MHC class II polypeptides, and one or more immunomodulatory polypeptides.
Ronald D. Seidel, III, Rodolfo J. Chaparro, John F. Ross, Chee Meng Low
Filed: 8 Feb 23
Utility
T-cell Modulatory Multimeric Polypeptides and Methods of Use Thereof
19 Oct 23
The present disclosure provides variant immunomodulatory polypeptides, and fusion polypeptides comprising the variant immunomodulatory peptides.
Ronald D. Seidel, III, Rodolfo J. Chaparro
Filed: 3 Oct 22
Utility
MHC Class II T-cell Modulatory Multimeric Polypeptides for Treating Type 1 Diabetes Mellitus (T1D) and Methods of Use Thereof
12 Oct 23
The present disclosure provides T-cell modulatory multimeric polypeptides (TMMPs) comprising a type 1 diabetes (T1D)-associated peptide epitope, MHC class II polypeptides, and one or more immunomodulatory polypeptides.
Ronald D. Seidel, III, Rodolfo J. Chaparro, John F. Ross, Chee Meng Low
Filed: 8 Feb 23
Utility
Methods for modulating an immune response
26 Sep 23
The present disclosure provides methods of modulating an immune response in an individual.
Ronald D. Seidel, III, Rodolfo J. Chaparro
Filed: 6 Oct 22
Utility
T-cell Modulatory Multimeric Polypeptides and Methods of Use Thereof
7 Sep 23
The present disclosure provides T-cell modulatory multimeric polypeptides comprising two different immunomodulatory polypeptides, at least one of which is a variant immunomodulatory polypeptide.
Ronald D. Seidel, III, Rodolfo J. Chaparro
Filed: 3 Oct 22
Utility
T-Cell Modulatory Polypeptides with Conjugation Sites and Methods of Use Thereof
7 Sep 23
The present disclosure provides T cell modulatory polypeptides (T-Cell-MPs) comprising a chemical conjugation site and at least one immunomodulatory polypeptide sequence that may be selected to exhibit reduced binding affinity to its cognate co-immunomodulatory polypeptide.
Ronald D. SEIDEL, III, Rodolfo J. CHAPARRO, John F. ROSS, Chee Meng LOW, Anish SURI, Raymond J. MONIZ, Gurpanna SAGGU
Filed: 14 Jul 21
Utility
T-cell Modulatory Multimeric Polypeptides and Methods of Use Thereof
17 Aug 23
The present disclosure provides variant immunomodulatory polypeptides, and fusion polypeptides comprising the variant immunomodulatory peptides.
Ronald D. Seidel, III, Rodolfo J. Chaparro
Filed: 13 Dec 22
Utility
T-cell modulatory multimeric polypeptides and methods of use thereof
25 Jul 23
The present disclosure provides variant immunomodulatory polypeptides, and fusion polypeptides comprising the variant immunomodulatory peptides.
Ronald D. Seidel, III, Rodolfo J. Chaparro
Filed: 21 Jun 22
Utility
T-cell Modulatory Multimeric Polypeptides and Methods of Use Thereof
20 Jul 23
The present disclosure provides variant immunomodulatory polypeptides, and fusion polypeptides comprising the variant immunomodulatory peptides.
Ronald D. Seidel, III, Rodolfo J. Chaparro
Filed: 12 Aug 22
Utility
T-cell modulatory multimeric polypeptides comprising reduced-affinity immunomodulatory polypeptides
18 Jul 23
The present disclosure provides T-cell modulatory multimeric polypeptides that comprise an immunomodulatory polypeptide that exhibits reduced binding affinity to a cognate co-immunomodulatory polypeptide.
Ronald D. Seidel, III, Rodolfo J. Chaparro
Filed: 23 Jun 20
Utility
Antigen Presenting Polypeptide Complexes and Methods of Use Thereof
13 Jul 23
The present disclosure provides Multimeric Antigen-Presenting Polypeptides (MAPPs) for the presentation of epitopes in the context of a class II MHC receptor.
Ronald D. SEIDEL, III, Rodolfo J. CHAPARRO, John F. ROSS, Chee Meng LOW
Filed: 26 May 21
Utility
T-cell Modulatory Multimeric Polypeptides and Methods of Use Thereof
13 Jul 23
The present disclosure provides variant immunomodulatory polypeptides, and fusion polypeptides comprising the variant immunomodulatory peptides.
Ronald D. Seidel, III, Rodolfo J. Chaparro
Filed: 6 Oct 22