159 patents
Page 2 of 8
Utility
Metabolite Fingerprinting
16 Mar 23
The present disclosure provides methods for predicting phenotypic performance of a host cell in industrial culture.
Erik Jedediah DEAN, Stephen LOK, Ana Belen IBANEZ ZAMORA, Ee-Been GOH, Stefan BAUER, Franklin LU
Filed: 16 Nov 22
Utility
Selecting Biological Sequences for Screening to Identify Sequences That Perform a Desired Function
9 Mar 23
Systems, methods, and non-transitory computer-readable media are described for identifying candidate biological sequences for screening to determine whether the candidate biological sequences enable a biological function.
Eyal Akiva, Rebecca Davidson, Stepan Tymoshenko
Filed: 12 Feb 21
Utility
Genome Editing Using Crispr In Corynebacterium
9 Mar 23
A CRISPR system is successfully used to modify the genomes of a gram-positive bacterium, such as a species of the Cornybacterium genus.
Stephen BLASKOWSKI, Robert COATES, Kedar PATEL, Hendrik Marinus VAN ROSSUM, Shawn SZYJKA
Filed: 3 Aug 22
Utility
Device-agnostic system for planning and executing high-throughput genomic manufacturing operations
14 Feb 23
High-throughput production of modified microbes is achieved through optimization of directed build graph data structures representing biological workflows.
Kiyan Ahmadizadeh, Tessa Alexanian, Barbara Frewen, Prasad Ganesan, Aaron Kimball, William J. Mania, Zachary Palchick, Erin Rhode, Dylan Webster
Filed: 25 Oct 18
Utility
High-throughput Automated Strain Library Generator
9 Feb 23
A method for automated, high throughput cellular library generation is disclosed.
Sara da Luz Areosa CLETO, Philip D. WEYMAN
Filed: 4 Oct 22
Utility
Identifying organisms for production using unsupervised parameter learning for outlier detection
7 Feb 23
Systems, methods and computer-readable media are provided for identifying organisms for production.
Amelia Taylor
Filed: 30 Nov 18
Utility
Filament Comprising a Thermoplastic Polyimide and Three-dimensional Body Made from the Filament
26 Jan 23
In one embodiment, a filament can comprise a thermoplastic polyimide, wherein the filament is adapted for use in a fused filament fabrication process and the thermoplastic polyimide may have a glass transition temperature not greater than 215° C.
Patrick Gerardus DUIS, Kenneth Angus KEMPINSKI, Justin KERSZULIS
Filed: 30 Jun 22
Utility
Genetic perturbation of the RNA degradosome protein complex
10 Jan 23
The present disclosure provides novel bacterial strains with altered expression or start codon modification of one or more RNA degradation/processing genes.
Shawn Manchester
Filed: 27 Jun 17
Utility
Genomic engineering of biosynthetic pathways leading to increased NADPH
6 Dec 22
The disclosure relates to host cells having altered NADPH availability, allowing for increased production of compounds produced using NADPH, and methods of use thereof.
Shawn Manchester, Benjamin Mason, Alexi Goranov
Filed: 18 May 18
Utility
Compositions and Methods for Synthesis of Terpenoids
10 Nov 22
The disclosure relates to the biosynthesis of terpenoids, such as, for example, geraniol and derivatives thereof, using genetic engineering.
Stefan DE KOK, Warren LAU, Fern MCSORLEY, Hermann-Josef MEYER, Zach SERBER, Grayson WAWRZYN
Filed: 26 Jun 20
Utility
Metagenomic library and natural product discovery platform
8 Nov 22
The present disclosure provides methods and systems for identifying natural product-encoding multi-gene clusters (MGCs).
Oliver Liu, Eyal Akiva, Tom Hayon Eyles, Ute Galm, Sangita Ganesh, Stephanie Leanne Brown Hendrix, William W. Hwang, Jeffrey Hoon Kim, Alexander Neckelmann, Samuel Oteng-Pabi, Claus Pelikan, Devin Scannell, Zachariah Serber, Jennifer Shock, Michael W. Sneddon, Xiao Yang
Filed: 21 Sep 21
Utility
Systems and methods for high-throughput automated strain generation for non-sporulating fungi
25 Oct 22
Embodiments disclosed include systems and methods to generate and/or improve non-sporulating filamentous fungal cells using high-throughput techniques.
Benjamin Knox, Nasim Mansoori Zangir, Ryan Evan Martinez, Hassan Abdulla
Filed: 28 Jul 21
Utility
Downscaling Parameters to Design Experiments and Plate Models for Micro-organisms at Small Scale to Improve Prediction of Performance at Larger Scale
13 Oct 22
Systems, methods and computer-readable media are provided for designing experiments for organisms at a first scale to generate first-scale performance data used in predicting performance of the organisms at a second, larger scale.
Stefan De Kok, Peter Enyeart, Richard Hansen, Trent Hauck, Crystal Humphries, Sarah Lieder, Zachariah Serber, Erin Shellman, Amelia Taylor, Thomas Treynor, Kristina Tyner
Filed: 5 May 20
Utility
Promoters from Corynebacterium Glutamicum
13 Oct 22
Provided are native promoters comprising polynucleotides isolated from Corynebacterium glutamicum, and mutant promoters derived therefrom, which may be used to regulate, i.e., either increase or decrease, gene expression.
Zachariah SERBER, Katherine G. GORA, Shawn P. MANCHESTER
Filed: 25 Mar 22
Utility
Apparatuses and methods for electroporation
11 Oct 22
Disclosed are apparatuses, systems, and methods for performing electroporation.
John Cesarek, Travis Lee, Richard Hansen
Filed: 26 Jun 20
Utility
Engineered Biosynthetic Pathways for Production of Cystathionine by Fermentation
6 Oct 22
The present disclosure describes the engineering of microbial cells for fermentative production of cystathionine and provides novel engineered microbial cells and cultures, as well as related cystathionine production methods.
Cara Ann Tracewell, Alexander Glennon Shearer, Anupam Chowdhury, Steven M. Edgar
Filed: 24 Jun 20
Utility
Metal-organic framework materials
27 Sep 22
The present disclosure provides novel metal-organic framework materials (MOFs) useful, for example, for gas adsorption, storage, and/or separation.
Adam Safir, Adam J. Matzger, Shantel Leithead, Jialiu Ma, Gregory W. Peterson, John McNamara
Filed: 17 Jul 18
Utility
Powder Composition Comprising Polyimide Particles, Three-dimensional Polyimde-based Body, and Method of Forming the Body
22 Sep 22
In one embodiment, a powder composition can comprise polyimide particles, wherein the polyimide particles can have a glass transition temperature of not greater than 200° C. and a crystallinity of not greater than 20%.
Patrick Gerardus Duis, John Colby Chastain, Justin Kerszulis, Kenneth Kempinski
Filed: 17 Mar 22
Utility
Engineered Biosynthetic Pathways for Production of 3-AMINO-4-HYDROXYBENZOIC Acid by Fermentation
8 Sep 22
The present disclosure describes the engineering of microbial cells for fermentative production of 3-amino-4-hydroxybenzoic acid and provides novel engineered microbial cells and cultures, as well as related 3-amino-4-hydroxybenzoic acid production methods.
Cara Ann Tracewell, Alexander Glennon Shearer
Filed: 10 Aug 20
Utility
HTP Genomic Engineering Platform
1 Sep 22
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols.
Zachariah SERBER, Erik Jedediah DEAN, Shawn MANCHESTER, Katherine GORA, Michael FLASHMAN, Erin SHELLMAN, Aaron KIMBALL, Shawn SZYJKA, Barbara FREWEN, Thomas TREYNOR, Kenneth S. BRUNO
Filed: 17 May 22